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  • 1
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    London ; New York : Spon Press
    Keywords: Cable structures. ; Lightweight construction. ; Tensile architecture.
    Pages: 1 v. (various pagings)
    ISBN: 0-203-42049-7
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  • 2
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    East Lansing, Mich : Michigan State University
    Keywords: Rural development, Sociological aspects, Cross-cultural studies. ; Rural population, Cross-cultural studies. ; Rural population, United States. ; Sociology, Rural. ; Sociology, Rural, Research.
    Notes: The poor in nonmetropolitan America / William P. O'Hare -- Mechanization in the western Upper Peninsula pulp-logging industry / Jon H. Rieger -- Development, women's work, and economic inequality in rural Taiwan / Rita S. Gallin -- Inequality and the emergence of nonfarm employment in Rwanda / Daniel C. Clay, Theobald Kampayana, and Jean Kayitsinga -- Social and economic transformation in a Greek farming village / George A. Daoutopoulos -- Recent population change in Michigan's metropolitan and nonmetropolitan areas / Ching-li Wang -- The transmission of information regarding population change in a rural county / Richard W. Rathge -- Fatal farm accidents in Michigan : implications for research and policy / Nan E. Johnson -- Irish rural-urban migration: post-1960 changes / Damian F. Hannan -- Changing rural communities : reconstructing the local economy of a nonmetropolitan community / Marilyn W. Aronoff -- Social change and dress among the Kalabari of Nigeria / Joanne Bubolz Eicher -- The call of the sugar cane : agricultural change, cooperative-capitalism, and migrants in northwestern Uruguay / Gaston J. Labadie
    Pages: x, 255 p.
    ISBN: 0-585-20090-4
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  • 3
    Keywords: Medicine ; Radiology, Medical ; Nuclear Medicine ; Medicine & Public Health ; Imaging / Radiology ; Nuclear Medicine ; Springer eBooks
    ISBN: 9783642276002
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  • 4
    Keywords: Life sciences ; Human Genetics ; Cell Biology ; Life sciences ; Cell Biology ; Human Genetics ; Springer eBooks
    Description / Table of Contents: How far can mitochondrial DNA drive the disease? -- Mitochondrial DNA in lung cancer -- Approach, application and bioethics of mtDNA sequencing in cancer -- Roles of mitochondrial DNA signaling in immune responses -- Mitochondrial DNA in Telocytes -- Roles of mitochondrial DNA in energy metabolism -- The role of base excision repair in maintaining mitochondrial DNA stability.-℗ Is mitochondrial cell fragility a cell weakness? -- Mitochondrial DNA methylation and related disease -- Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis -- Metabolic regulation in mitochondria and drug resistance.-℗ Mitochondrial Lon Protease and Cancer -- Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology.-Epithelial mitochondrial dysfunction in lung disease
    Abstract: The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. ℗ Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA€“ássociated diseases
    Pages: VII, 230 p. 89 illus., 62 illus. in color. : online resource.
    ISBN: 9789811066740
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  • 5
    Keywords: Life sciences ; Plant Biochemistry ; Microbiology ; Plant science ; Botany ; Mycology ; Life sciences ; Mycology ; Plant Biochemistry ; Microbiology ; Plant Sciences ; Springer eBooks
    Description / Table of Contents: Part 1. Medicinal Properties / Therapeutic Effects - Medicinal Plants and Fungi -- Chapter 1. Centella asiatica, an Ayurvedic Medicinal Plant, Prevents the Major Neurodegenerative and Neurotoxic Mechanisms Associated with Cognitive Impairment -- Chapter 2. Medicinal properties of Mediterranean Oyster mushrooms, species of genus Pleurotus (higher Basidiomycetes) -- Chapter 3. Cordyceps ́€“ A Highly Coveted Medicinal Mushroom -- Chapter 4. Medicinal Mushrooms with Antiallergic Activities -- Chapter 5. The Bioactivity of Tiger Milk Mushroom - Malaysia's Prized Medicinal Mushroom -- Chapter 6. Antioxidant Properties of Antrodia cinnamomea ́€“ An Extremely Rare and Coveted Medicinal Mushroom Endemic to Taiwan -- Part 2. Bioactive Compounds ́€“ Medicinal Plants and Fungal Endophytes -- Chapter 7. The Fungal Endobiome of Medicinal Plants: A Prospective Source of Bioactive Metabolites -- Chapter 8. Multipotent and Poly-Therapeutic Fungal Alkaloids of ℗ Claviceps purpurea -- Chapter 9. Recent Advance On Bioactive Compounds From The Edible And Medicinal fungi in China -- Chapter 10. Endophytes From Malaysian Medicinal Plants As Sources For Discovering Anticancer Agents -- Chapter 11. Mushrooms: A Pandora Box of Cardioprotective Phytochemicals -- Part 3. Production Systems and Biotechnology - ℗ Medicinal Plants and Fungi -- Chapter 12. Solid State Fermentation Of Plant Residues And Agro-Industrial Wastes For The Production Of Medicinal Mushrooms -- Chapter 13. ℗ Making Use of Genomic Information to Explore the Biotechnological Potential of Medicinal Mushrooms -- Chapter 14. Biotechnology of Medicinal Plants and Fungi in Taiwan ́€“Production of Bioactive Secondary Metabolites in In Vitro Culture Systems -- Part 4. Resources / Techniques ́€“ Medicinal Plants and Fungi -- Chapter 15. Memory Enhancing and Related Beneficial Effects of Selected Medicinal Plants From the Nigerian Flora -- Chapter 16. Identification Strategies For Bioactive Secondary Metabolites Of Fungal Origin
    Abstract: This book highlights the latest international research on different aspects of medicinal plants and fungi. Studies over the last decade have demonstrated that bioactive compounds isolated from medicinal fungi have promising antitumor, cardiovascular, immunomodulatory, anti-allergic, anti-diabetic, and hepatoprotective properties. In the light of these studies, the book includes chapters (mostly review articles) by eminent researchers from twelve countries across the globe working in different disciplines of medicinal plants and fungi. It discusses topics such as the prevention of major neurodegenerative and neurotoxic mechanisms by Centella asiatica; the medicinal properties and therapeutic applications of several mushrooms species found in different parts of the world; and fungal endophytes as a source of bioactive metabolites including anticancer and cardioprotective agents. There are also chapters on strategies for identifying bioactive secondary metabolites of fungal origin; the use of genomic information to explore the biotechnological potential of medicinal mushrooms; and solid state fermentation of agro-industrial and forestry residues for the production of medicinal mushrooms. It is a valuable resource for the researchers, professionals and students working in the area of medicinal plants and fungi
    Pages: XX, 547 p. 134 illus., 40 illus. in color. : online resource.
    ISBN: 9789811059780
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  • 6
    Keywords: Life sciences ; Metabolism ; Botany ; Plant breeding ; Life sciences ; Plant Sciences ; Plant Genetics & Genomics ; Metabolomics ; Springer eBooks
    Description / Table of Contents: Overview -- Gas Chromatography Mass Spectrometry Coupling Techniques -- LC-MS in Plant Metabolomics -- Nuclear Magnetic Resonance Techniques -- Multivariate Analysis of Metabolomics Data -- Metabolomic data processing based on mass spectrometry platforms -- Metabolite Qualitative Methods and the Introduction of Metabolomics Database -- Plant Metabolic Network -- Applications of LC-MS in plant metabolomics -- Application of Metabolomics in the Identification of Chinese Herbal Medicine -- Metabolomics based Studies on Artemisinin Biosynthesis -- NMR-Based Metabolomic Methods and Applications -- Metabolomics research of quantitative disease resistance against barley leaf rust
    Abstract: This book introduces plant metabolomics, an experimental approach that is important in both functional genomics and systems biology. It can be argued that metabolite data is most closely linked to phenotypes and that changes in metabolite content or metabolic networks can therefore indicate gene function more directly than mRNA transcript or protein based-approaches. Additionally, the identification of metabolic markers has important applications in plant breeding. The book, written by researchers who are active in plant metabolomics in China, not only introduces the fundamental concepts and the latest methodological advances in the field of plant metabolomics, but also details new studies from the respective scientific programs of the authors and thus reflects the current state of domestic plant metabolomics research.℗ Professor Xiaoquan Qi is the principal investigator at the Institute of Botany, CAS. Professor℗ Xiaoya Chen is a member of the Chinese Academy of Science and also is the℗ principal investigator at the Shanghai Institutes for Biological Sciences, CAS. Professor Yulan Wang is leading a team in BioSpectroscopy and Metabolomics at the Wuhan Institute of Physics and Mathematics, CAS
    Pages: VIII, 319 p. 144 illus., 73 illus. in color. : online resource.
    ISBN: 9789401792912
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  • 7
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: 1 Antibody-Drug Conjugates: A Historical Review -- 2 Payloads of Antibody-Drug Conjugates -- 3 Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy -- 4 Linker Design for Antibody-Drug Conjugates -- 5 Formulation Development for Antibody-Drug Conjugates -- 6 Bioanalytical Assay for Characterization of Antibody Drug Conjugates -- 7 Pharmacokinetics/Pharmacodynamics and Disposition of Antibody-Drug Conjugates -- 8 Regulatory Considerations -- 9 Major ADC Companies, Current Clinical Trials, Recent Patents Issued and Patent Applications, and Cost Analysis of Drug Therapy -- 10 Mylotarg: Revisiting its Clinical Potential Post-Withdrawal -- 11 ADCETRIS: A Regulatory Case Study of a New Generation Antibody Drug Conjugate -- 12 Ado-Trastuzumab Emtansine -- 13 The Antibody-Drug Conjugate Glembatumumab Vedotin (CDX-011) and its Use in Treatment of Breast Cancer -- 14 Summary and Future Directions
    Abstract: This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field
    Pages: X, 252 p. 59 illus., 32 illus. in color. : online resource.
    ISBN: 9783319130811
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  • 8
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    Hoboken, N.J. : Wiley
    Call number: WB200:50 ; E131:4
    Keywords: Optics ; Light ; Models, Theoretical ; Diagnostic Imaging / methods ; Tomography, Optical / methods
    Description / Table of Contents: Rayleigh theory and Mie theory for a single scatterer -- Monte Carlo modeling of photon transport in biological tissue -- Convolution for broadbeam responses -- Radiative transfer equation and diffusion theory -- Hybrid model of Monte Carlo method and diffusion theory -- Sensing of optical properties and spectroscopy -- Ballistic imaging and microscopy -- Optical coherence tomography -- Mueller optical coherence tomography -- Diffuse optical tomography -- Photoacoustic tomography -- Ultrasound-modulated optical tomography
    Pages: xiv, 362 p. : ill.
    ISBN: 9780471743040
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    WB200:50 available
    E131:4 departmental collection or stack – please contact the library
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  • 9
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    Cary, NC : SAS Institute
    Call number: C020:87
    Keywords: Mathematical statistics / Data processing ; SAS (Computer file)
    Pages: xviii, 372 p.
    ISBN: 1580252931
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    C020:87 departmental collection or stack – please contact the library
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  • 10
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    Singapore : Springer Singapore
    Keywords: Medicine ; Pharmacology ; Nanochemistry ; Cell Biology ; Invertebrates ; Biomedicine ; Pharmacology/Toxicology ; Nanochemistry ; Cell Biology ; Invertebrates ; Springer eBooks
    Description / Table of Contents: Values of C. elegans in Toxicological Study -- Endpoints for Toxicity Assessment of Nanomaterials -- Exposure Routes of Nanomaterials -- Toxic Effects of Certain Nanomaterials -- Physicochemical Basis for Nanotoxicity Formation -- Cellular and Physiological Mechanisms of Nanotoxicity Formation -- Molecular Mechanisms of Nanotoxicity Formation -- Distribution and Translocation of Nanomaterials -- Confirmation of Nanomaterials with Low-Toxicity or Non-Toxicity Property -- Surface Chemical Modification to Reduce the Toxicity of Nanomaterials -- Pharmacological Prevention of the Toxicity Induced by Environmental Nanomaterials
    Abstract: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs’ translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans
    Pages: X, 274 p. 123 illus., 103 illus. in color. : online resource.
    ISBN: 9789811302336
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