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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch); 20080601-20080604; Würzburg; DOCMO.06.04 /20080530/
    Publication Date: 2008-05-30
    Keywords: craniosynostosis ; developmental anomaly ; Kraniosynostose ; Entwicklungsstörung ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    Keywords: RECEPTOR ; CELLS ; EXPRESSION ; CELL ; Germany ; human ; TYROSINE KINASE ; PROTEIN ; RNA ; cell line ; LINES ; TRANSDUCTION ; ACTIVATION ; COMPLEX ; RESPONSES ; COMPLEXES ; CUTTING EDGE ; DENDRITIC CELLS ; CELL-LINES ; PHOSPHORYLATION ; signal transduction ; SIGNAL ; MOUSE ; PATTERNS ; SIGNAL-TRANSDUCTION ; CELL-LINE ; LINE ; B-CELLS ; NATURAL-KILLER-CELLS ; NK cells ; cell lines ; REGULATOR ; NEUTROPHILS ; signaling ; RE ; PRODUCTS ; INTERFERENCE ; RNA INTERFERENCE ; LEADS ; CYTOKINE PRODUCTION ; LEVEL ; SIGNALS ; B-CELL ; immunology ; DAP12 ; AMPLIFIES INFLAMMATION ; PHOSPHOLIPASE C-GAMMA-1
    Abstract: The engagement of triggering receptor expressed on myeloid cells 1 (TREM-1) on macrophages and neutrophils leads to TNF-alpha and IL-8 production and enhances inflammatory responses to microbial products. For signal transduction, TREM-1 couples to the ITAM-containing adapter DNAX activation protein of 12 kDa (DAP12). In general, ITAM-mediated signals lead to cell activation, although DAP12 was recently implicated in inhibitory signaling in mouse macrophages and dendritic cells. To date, signals downstream of the TREM-1 and DAP12 complex in myeloid cells are poorly defined. By analyzing receptor-induced tyrosine phosphorylation patterns, we discovered that the ligation of TREM-1 leads to tyrosine phosphorylation of the non-T cell activation linker (NTAL; also called linker of activation in B cells or LAB) in a myelomonocytic cell line and primary human granulocytes. Using RNA interference to decrease the expression levels of NTAL, we demonstrate that in NTAL knockdown cell lines the phosphorylation of ERK1/2 is enhanced. In addition, low levels of NTAL are correlated with decreased and delayed mobilization of Ca2+ after TREM-1 triggering. Most importantly, we demonstrate that NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1. Our results show that activation signals delivered via DAP12 can be counterbalanced by the adaptor NTAL, identifying NTAL as gatekeeper of TREM-1/DAP12-induced signaling in myeloid cells. The Journal of Immunology, 2007, 178: 1991-1999
    Type of Publication: Journal article published
    PubMed ID: 17277102
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Evidenzbasierte Primärversorgung und Pflege; 9. Jahrestagung Deutsches Netzwerk Evidenzbasierte Medizin und Kongress der Deutschen Gesellschaft für Pflegewissenschaft; 20080222-20080223; Witten; DOC08ebmP34 /20080212/
    Publication Date: 2008-02-12
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    ISSN: 1615-6714
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Fortythree out of 148 patients who had undergone velopharyngeal flap graft between 1980 and 1992 to treat velopharyngeal insufficiency, and for whom pre- and postoperative data were available, were studied for the purpose of determining the long term morphological functional results of the treatment. Almost all of the 43 patients (93,5%) had received a velopharyngeal flap graft according toSanvenero-Rosselli. The remaining 4.7% had received a velopharyngeal adhesion according toStellmach. Four physicians from the fields of oral surgery, orthodontics, phoniatries, and logopedies evaluated the pre- and postoperative data as well as the results of the follow-up examination according to subjective criteria from their respective disciplines. All four physicians judged that following velopharyngeal flap graft a gradual improvement in the ability to speak had been achieved in 86% of the patients in the follow-up study. At the time of the follow-up examination 70% of these cases were judged to have achieved a “good” qualitative level of articulation and 21% were judged to have achieved a “usefull” level. The best results were obtained in patients who had been operated on before the age of six. The reason is that in these young patients muscular malfunction and pathological movement patterns can be more easily modified than in okler patients. In many cases additional speech improvement was achieved through logopedical therapy following the velopharyngeal flap graft. In the most difficult cases intensive therapy while the patients were still hospitalized proved to be especially effective. The pre-operative use of transnasal flexible endoscopy to evaluate the interaction of the structures bearing on velopharyngeal closure proved its value in evaluating velopharyngeal flap graft's chances of success. Velopharyngeal flap graft thus offers the possibility of an efficacious treatment of velopharyngeal insufficiency, if both the preoperative diagnosis and postoperative therapy draw on the expertise of the above noted fields in an interdisciplinary common effort in which the limits of the treatment method are clearly taken into consideration.
    Notes: Zusammenfassung Von 148 Patienten, bei denen im Zeitraum von 1980 bis 1992 wegen einer velopharyngealen Insuffizienz eine Velopharyngoplastik durchgeführt wurde sowie prä- und postoperative Befunde vorlagen, wurden 43 Betroffene zur Einschätzung der morphologischen und funktionellen Spätresultate nachuntersucht. Bei 95,3% aller nachuntersuchten Patienten wurde eine Velopharyngoplastik nachSanvenero-Rosselli [15] und bei 4,7% eine Velopharynxadhäsion nachStellmach [19] durchgeführt. Die prä- und postoperative Beurteilung sowie die Nachuntersuchung erfolgten dabei nach subjektiven Kriterien durch Fachvertreter der Kieferchirurgie, Kieferorthopädie, Phoniatrie und Logopädie. Bei 86% der nachuntersuchten Patienten konnte nach Beurteilung aller Fachvertreter eine graduelle Sprachverbesserung mit einer Velopharyngoplastik erreicht werden. Zum Zeitpunkt der Nachuntersuchung war die Sprachqualität in 70% der Fälle gut und bei 21% branchbar beurteilt worden. Bei einer sprachverbessernden Operation vor dem sechsten Lebensjahr wirden die besten Ergebnisse erreicht, da zu diesem Zeitpunkt muskuläre Fehlfunktionen und pathologische Bewegungsmuster noch leichter umgestellt werden können. Eine weitere Verbesserung der Sprachqualität konnte in vielen Fällen durch eine logopädische Übungsbehandlung nach der Velopharyngoplastik erzielt werden. Die stationäre Intensivtherapie hat sich besonders bei schweren Fällen bewährt. Zur Abschätzung der Erfolgsaussichten einer Velopharyngoplastik hat sich die präoperative transnasale flexible Endoskopie zur Beurteilung des Zusammenspiels der am velopharyngealen Verschluß beteiligten Strukturen bewährt. Bei einer sachgerechten Indikationsstellung und effektiven Behandlung unter kritischer Berücksichtigung der Grenzen dieser Methodik in interdisziplinärer Zusammenarbeit ist die Velopharyngoplastik eine gute Möglichkeit zur Behandlung der velopharyngealen Insuffienz.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0165-1781
    Keywords: Adrenocorticotropic hormone ; cortisol ; depression ; dexamethasone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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