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  • 1
    Book
    Book
    Stuttgart ; : Gustav Fischer,
    Call number: 01-Ausbildungsl:842 ; V230:003
    Type of Medium: Book
    Pages: xii, 419 p. : , ill.
    Edition: 2. Auflage
    ISBN: 3-8304-1009-3
    Language: German
    Location: DKFZ
    Location: DKFZ
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  • 2
    Book
    Book
    Stuttgart : : Enke,
    Call number: S040:074 ; SF77:139(3)
    Type of Medium: Book
    Pages: xii, 440 p. : , ill.
    Edition: 3., überarb. und erw. Aufl.
    ISBN: 978-3-8304-1077-5
    Language: German
    Location: DKFZ
    Location: DKFZ
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  • 3
    Book
    Book
    Stuttgart : : Enke Verlag,
    Call number: M300:279 ; W410:038 ; SF77:153(4) ; M300:402 ; M300:403
    Type of Medium: Book
    Pages: 532 p. : , ill.
    Edition: 4., überarb. Aufl.
    ISBN: 9783830412533
    Language: German
    Location: DKFZ
    Location: DKFZ
    Location: DKFZ
    Branch Library: DKFZ
    Branch Library: DKFZ
    Branch Library: DKFZ
    Branch Library: DKFZ
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  • 4
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Akne ; Pustulosis palmoplantaris ; SAPHO-Syndrom ; Sternocostoclavikuläre Hyperostose ; Rezidivierende multifokale Osteomyelitis ; Key words Acne conglobata ; Pustulosis palmoplantaris ; SAPHO-syndrome ; Chronic recurrent multifocal osteomyelitis ; Sternocostoclavicular hyperostosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report three new cases of the SAPHO syndrome. This acronyme consists of synovitis, acne, pustulosis, hyperostosis and osteitis. Symptoms of this syndrome, which may not all be present, are pustulotic skin diseases (pustulosis palmoplantaris or severe acne) associated with osteoarticular lesions (mainly sternoclavicular hyperostosis, spondylarthropathies or chronic recurrent multifocal osteomyelitis). The dermatological aspects of this syndrome are discussed in detail.
    Notes: Zusammenfassung Das SAPHO-Syndrom (Synovitis, Akne, Pustulosis (palmoplantaris), Hyperostose und Osteitis) ist eine 1987 erstmals beschriebene Entität, bei der pustulöse Hauterkrankungen in Zusammenhang mit aseptischen osteoartikulären Läsionen auftreten. Die Ausprägungen des Syndroms sind vielfältig, häufig sind nicht alle Manifestationen bei einem Patienten vorhanden. Anhand von drei Patienten mit Akne conglobata und osteoartikulären Beschwerden werden insbesondere die dermatologischen Gesichtspunkte des Syndroms diskutiert.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Neurotrophische Ulzeration des Nasenflügels ; Wallenberg-Syndrom ; Neurotrophisches Trigeminussyndrom ; Key words Neurotrophic ulceration of the ala nasi ; Wallenberg's-syndrome ; Trigeminal Trophic Syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract A patient developed a trophic ulceration of the nose after an acute bulbar ischemia with infarction of the right trigeminal nuclei. Neurologic examination showed symptoms of a Wallenberg syndrome including ipsilateral hyp- and paresthesia of the second trigeminal branch and disturbed sensibility and temperature sense on the contralateral half of the body. The right ala nasi showed the characteristic sickle-shaped defect (ulcération en arc). The differential diagnosis and therapeutic approaches are discussed.
    Notes: Zusammenfassung Es wird über einen Patienten berichtet, bei dem es nach einer zentralen Ischämie mit Infarzierung der rechten Trigeminuskernregion zur Ausbildung einer Ulzeration am rechten Nasenflügel kam. Neurologisch zeigte sich das Bild eines Wallenberg-Syndroms mit rechtsseitiger Hyp- und Parästhesie im Versorgungsbereich des II. Trigeminusastes, bei dissoziierter Empfindungsstörung der linken Körperhälfte. Am rechten Nasenflügel fand sich ein charakteristischer, sichelförmiger Nasenflügeldefekt (“ulcération en arc”). Auf die differentialdiagnostischen Überlegungen sowie therapeutischer Ansätze bei neurotrophischer Ulzerationen wird hingewiesen.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Erythema elevatum et diutinum ; Morbus Crohn ; Leukozytoklastische Vaskulitis ; Neutrophile Granulozyten ; Key words Erythema elevatum diutinum ; Crohn's disease ; Leukocytoclastic vasculitis ; Neutrophilic granulocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 35-year-old woman suffering from Crohn's disease for 3 years developed painful erythematous nodular lesions predominantly on the dorsa of her hands and feet, as well as on her elbows and wrists. The clinical features and histopathological picture of leukocytoclastic vasculitis were both highly suggestive of erythema elevatum diutinum. No improvement of the skin lesions was observed during treatment with high doses of oral steroids. In contrast, treatment with dapsone® resulted in a marked reduction of skin lesions. During a new attack of her Crohn's disease the erythema elevatum diutinum lesions flared again. The parallel clinical course of erythema elevatum diutinum and Crohn's disease, as well as the detection of immune complexes and neutrophilic granulocytes in lesions of both diseases, strongly suggest a common etiology. This hypothesis is discussed in context with this case and the recent literature.
    Notes: Zusammenfassung Bei einer 35jährigen Patientin, bei der vor 3 Jahren ein Morbus Crohn diagnostiziert wurde, bestanden seit dieser Zeit mit zunehmender Tendenz druckschmerzhafte erythematös-papulös bis knotige Hautveränderungen über den Handgelenken, Fußgelenken und Ellbogen. Aufgrund des klinischen Bilds und des dermatologisch-histopathologischen Befunds einer leukozytoklastischen Vaskulitis stellten wir die Diagnose eines Erythema elevatum et diutinum. Trotz hochdosierter Stereoidtherapie des Morbus Crohn kam es zu einer deutlichen Verschlechterung des Hautbilds. Erst unter der Therapie mit Dapson kam es schließlich zu einer deutlichen Besserung des Hautbilds, das sich jedoch bei weiteren Schüben des Morbus Crohn erneut verschlimmerte. Dieser phasenhafte Verlauf des Erythema elevatum et diutinum mit Bezug auf die Aktivität des Morbus Crohn könnte auf eine gemeinsame Pathogenese beider Erkrankungen schließen lassen. Die bei beiden Erkrankungen vorkommenden ätiologischen Faktoren von Immunkomplexen und neutrophilen Granulozyten untermauern diese Annahme, die anhand des vorliegenden Falls und der aktuellen Literatur diskutiert wird.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Mutations of the tumour-suppressor gene NF1 (neurofibromatosis 1) have been observed in neurofibromas and neurofibrosarcomas of patients with von Recklinghausen's disease and in sporadic nerve sheath tumours. In contrast, melanoma, another tumour type of neuroectodermal origin, rarely shows NF1 alterations. Desmoplastic neurotropic melanoma (DNM) is an uncommon melanoma subtype that shares morphological characteristics with nerve sheath tumours. Therefore, we analysed 15 DNM and 20 melanomas without morphological features of desmoplasia or neuroid differentiation (common melanomas) for loss of heterozygosity (LOH) at the NF1 locus and flanking regions. Allelic loss was detected in 10/15 (67%) DNM but only in 1/20 (5%) common melanomas. LOH was most frequently observed at marker IVS38, located in intron 38 of NF1. These data suggest a role for NF1 in the pathogenesis of DNM and support an earlier hypothesis that exon 37 might encode a functional domain. DNM may represent an interesting tumour model for the further elucidation of the cellular functions and tumour-suppressive potential of neurofibromin.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Amikrobielle-Pustulose ; Autoimmunerkrankungen ; Neutrophile Dermatose ; Key words Amicrobial pustulosis ; Autoimmune disease ; Neutrophilic dermatosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary During the last decade an unusual amicrobial intertriginous pustulosis has been described in association with autoimmune disease in sixteen female patients. The clinical hallmark is a sterile pustular dermatosis preferentially located in intertriginous regions that responds to local or systemic corticosteroids. Histologic features are subcorneal sometimes spongiform neutrophilic pustules. We report an additional patient suffering from this unusual dermatosis. An overview of the patients described to date and a review of the literature are given in an attempt to delineate this amicrobial intertriginous pustulosis from the known pustular dermatoses.
    Notes: Zusammenfassung In der letzten Dekade wurde bei insgesamt 16 Patientinnen, die an einer Autoimmunerkrankung litten, eine ungewöhnliche amikrobielle intertriginöse Dermatose beschrieben. Das klinische Charakteristikum war eine sterile pustulöse Dermatitis v.a. in intertriginösen Regionen, die durch lokale oder meist systemische Steroidtherapie gebessert werden konnte. Histologisch imponierten subkorneale teilweise spongiforme neutrophile Pustulationen. Die vorliegende Arbeit beschreibt eine weitere Patientin mit dieser ungewöhnlichen Dermatose. In einer Literaturübersicht soll anhand der bislang beschriebenen Fälle versucht werden, eine Abgrenzung von bekannten pustulösen Dermatitiden durchzuführen.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-069X
    Keywords: Key words Loss of heterozygosity ; Melanoma ; p73 ; Tumor suppressor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-904X
    Keywords: testosterone, buccal administration ; testosterone, administration by bolus ; cyclodextrin-testosterone ; hydroxypropyl-β-cyclodextrin ; androgen-substitutional therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Testosterone, administered in the form of an inclusion complex with 2-hydroxypropyl-β-cyclodextrin by subcutaneous injection, enters the circulation in a manner markedly similar to the natural episodic release by the testes. The effects of a regimen of once-a-day administration of complexed testosterone to adult (castrated or intact) rats and to senescent (intact) rats were investigated. Although this procedure left the castrated animals with concentrations of circulatory hormone far below physiological levels for much of the day, a significant improvement in androgen-sensitive behavior and physiology was obtained. Furthermore, the testosterone effects were more pronounced when high doses were used periodically rather than when the same total amount of testosterone was equally divided among doses. The same supplementation to intact rats intensified androgen-sensitive behavior and physiology over normal levels. In senescent rats uniform pulses of the testosterone complex also improved behavior and physiology. Specifically, spermatogenesis was stimulated and, notably, the treatment increased muscle weight without substantial enlargement of the prostate. Since the testosterone–cyclodextrin complex also can be effectively administered as a sublingual tablet, the data suggest that similar regimens may be recommended for elderly men suffering from decreases in muscle mass.
    Type of Medium: Electronic Resource
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