Lipoprotein (a), kidney transplantation
Apoprotein (a), kidney transplantation
Cholesterol, kidney transplantation
Kidney transplantation, cholesterol
Kidney transplantation, hyperlipidaemia
Springer Online Journal Archives 1860-2000
Abstract Fasting plasma cholesterol, triglycerides, high-density lipoprotein (HDL) and apoprotein (apo) B were elevated in 214 nondiabetic renal transplant recipients renal transplant recipients when compared to a reference group. Apo (a) was slightly but not significantly lower in transplant recipients (median 118 mg/dl, range 16–1680 vs 130 mg/dl, 10–1176) and this difference could be predicted from Lp (a) isoform analysis. Cholesterol, triglyceride, apo B and apo (a) concentrations correlated negatively with creatinine clearance but none of these parameters showed a significant association with proteinuria. Patients treated with steroids had higher plasma HDL concentrations than those receiving cyclosporin monothetapy (P〈0.01). The use of diuretics was associated with raised triglycerides (P〈0.001) and cholesterol (P〈0.01) and with reduced HDL (P〈0.01) whilst patients receiving β-blockers had significantly higher triglycerides (P〈0.01) and lower HDL levels (P〈0.02). In multiple regression analysis, age (P〈0.01), creatinine clearance (P〈0.05) and diuretic therapy (P〈0.005) were independent risk factors for increased cholesterol whilst apo (a) levels correlated negatively with creatinine clearance (P〈0.005). These results suggest that impaired renal function, steroids and non-immunosuppressive drugs contribute to lipid abnormalites in renal transplant recipients.
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