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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20090520-20090524; Rostock; DOC09hnod427 /20090417/
    Publication Date: 2009-04-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.; 20050504-20050508; Erfurt; DOC05hno698 /20050922/
    Publication Date: 2005-09-23
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  84. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20130508-20130512; Nürnberg; DOC13hnod244 /20130415/
    Publication Date: 2013-04-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2015); 20151020-20151023; Berlin; DOCPO14-295 /20151005/
    Publication Date: 2015-10-06
    Keywords: Osteosarkom ; Epigenetik ; Estradiol ; Knochenstoffwechsel ; Estrogenrezeptor alpha ; ddc: 610
    Language: German
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  • 5
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The tissue localization was analysed of collagen X during human fetal and juvenile articular cartilagebone metamorphosis. This unique collagen type was found in the hypertrophic cartilage zone peri- and extracellularly and in cartilage residues within bone trabeculae. In addition, occasionally a slight intracellular staining reaction was found in prehypertrophic proliferating chondrocytes and in chondrocytes surrounding vascular channels. A slight staining was also seen in the zone of periosteal ossification and occasionally at the transition zone of the perichondrium to resting cartilage. Our data provide evidence that the appearance of collagen X is mainly associated with cartilage hypertrophy, analogous to the reported tissue distribution of this collagen type in animals. In addition, we observed an increased and often “spotty” distribution of collagen X with increasing cartilage “degeneration” associated with the closure of the growth plate. In basal hypertrophic cartilage areas, a co-distribution of collagens II and X was found with very little and “spotty” collagen III. In juvenile cartilage areas around single hypertrophic chondrocytes, co-localization of collagens X and I was also detected.
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  • 6
    ISSN: 1432-2307
    Keywords: Paleopathology ; Pulmonary haemorrhage ; Parasitosis ; Drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on the morphological and trace element findings of several internal organs from an Egyptian mummy approximately dating from the year 950 B.C. according to 14C-analysis. By use of a multidisciplinary approach we succeeded in discovering evidence for severe and presumably recurrent pulmonary bleeding during life. This was suggested by the finding of massive haemosiderin deposits in the lung and a selectively and markedly elevated level of iron in trace element analysis of the lung tissue. Furthermore, we observed an enhanced deposition of birefringent particles in the lung tissue, without significant fibrosis. The histological analysis of liver, stomach and intestine confirmed the macroscopic organ diagnoses without evidence of any major pathological processes. In addition, analysis for various drugs revealed a significant deposition of tetrahydrocannabinol (THC), nicotine and cocaine in several organs of the mummy. The concentration profiles additionally provide evidence for a preferential inhalation of THC, while nicotine and cocaine containing drugs seem to have been consumed orally.
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  • 7
    ISSN: 1437-1596
    Keywords: Histochemistry ; Collagen Type III ; Solophenyl-Red 3 BL ; Schlüsselwörter: Immunhistochemie ; Histochemie ; Kollagen Typ III ; Solophenyl-Rot 3 BL
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Zur Überprüfung der Spezifität der histochemischen Darstellung von Kollagen Typ III wurden Serienschnitte von 7 Hautwunden mit einem Wundalter zwischen 3 Tagen and 4 Wochen untersucht. Korrespondierende Präparate wurden nach der Solophenyl-Rot 3 BL-Methode and immunhistochemisch gefärbt, die Schnitte wurden licht- bzw. polarisationsmikroskopisch ausgewertet. Immunhistochemisch konnte in allen untersuchten Hautwunden Kollagen Typ III nachgewiesen werden. Nur 3 von 7 Solophenyl-Rot-gefärbten Hautwunden zeigten eine signifikante Rotfdrbung im Bereich der Läsion bei kräftiger Anfärbung des umgebenden Bin degewebes. Im polarisierten Licht konnten im Wundgebiet keine grün aufleuchtenden Fasern, die als charakteristisch für Kollagen Typ III aufgefaßt werden, beobachtet werden. Da keine Ubereinstimmung zwischen immunhistochemisch darstellbarem Kollagen Typ III und den unter polarisiertem Licht grünweiß aufleuchtenden Fasern in den Solophenyl-Rot-gefärbten Präparaten nachzuweisen war, muß eine Spezifität dieser histochemischen Färbemethode für Kollagen TypIII verneint werden.
    Notes: Summary In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to elucidate the specifity of the histochemical staining method. Large amounts of collagen type III were clearly detectable in the investigated wounds using the immunohistochemical technique. In the sections stained with Solophenyl-Red, however, only 3 out of 7 skin lesions showed a significant positive red staining at the wound margin or in the granulation tissue, while the adjacent normal connective tissue revealed a typical intensive staining. Using polarization microscopy no characteristic bright green fibrils, as reported for collagen type 111, could be seen in the wound areas without positive Solophenyl-Red staining. Since the localization of collagen type III detected by immunohistochemistry and the presumed distribution of this collagen type by the Solophenyl-Red method was not identical, the histochemical polarization method has to be regarded as non-specific for visualization of this collagen type.
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  • 8
    ISSN: 1437-1596
    Keywords: Collagen type IV ; Laminin ; Heparan sulfate proteoglycan ; Wound age ; Immunohistochemistry ; Kollagen IV ; Laminin ; Heparansulfat-Proteoglycan ; Wundalter ; Immunhistochemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung An insgesamt 62 menschlichen Hautwunden mit einer Überlebenszeit zwischen 5 Stunden und 6 Wochen wurde das wundaltersabhängige perizelluläre Auftreten der Basalmembran-Komponenten Kollagen Typ IV, Laminin und Heparansulfat-Proteoglycan (HSPG) in Myofibroblasten untersucht. Laminin und HSPG waren erstmals in einer 1,5 Tage überlebten Hautwunde nachweisbar, Kollagen IV konnte erst nach ca. 4 Tagen beobachtet werden. In Hautwunden mit einem Wundalter von 1 Woche und mehr konnte in 94% der Fälle Laminin, in 70% HSPG und in 63% Kollagen IV perizellulär nachgewiesen werden. Laminin trat hierbei nicht nur in einem höheren Prozentsatz der Fälle, sondern auch in einer größeren Anzahl von Myofibroblasten im Vergleich zu HSPG und v.a. zu Kollagen IV auf. Der positive Nachweis von Laminin oder HSPG bzw. von Kollagen IV in der perizellulären Region von Myofibroblasten weist somit auf ein Wundalter von mindestens ca. 1,5 bzw. 4 Tagen hin. Da die untersuchten Basalmembran-Komponenten auch noch um Myofibroblasten älterer Hautwunden (6 Wochen Wundalter) nachweisbar waren, kann durch die immunhistochemische Darstellung dieser Proteine keine zusätzliche Aussage über das Alter von Wunden mit längerer überlebenszeit getroffen werden. Die semiquantitative Auswertung ergab keine für eine Wundaltersbestimmung verwertbare Korrelation zwischen der Zahl positiv anfärbbarer Myofibroblasten und der überlebenszeit.
    Notes: Summary Human skin wounds (n = 62) with a wound age between 5 h and 6 weeks were investigated. The appearance of cell-associated pericellular basement membrane components collagen type IV, laminin and heparan sulfate proteoglycan (HSPG) in myofibroblasts was evaluated by immunohistochemistry. Laminin and HSPG were first detectable around myofibroblasts approximately 1.5 days after wounding. Collagen type IV did not appear before the 4th day after wound infliction. In wounds more than 7 days old, 94% of the cases showed fibroblastic cells positively staining for laminin, 70% of the wounds contained fibroblastic cells positive for HSPG and in 63% a positive reaction for collagen type IV was obtained around these cells. The numbers of the cases as well as of the cells positively stained for laminin exceeded the corresponding values for HSPG and especially for collagen type IV. The pericellular appearance of laminin or HSPG around myofibroblasts, therefore, indicates a wound age of at least approximately 1.5 days. The pericellular localization of collagen type IV indicates a survival time of approximately 4 days or more. Since these proteins are still detectable in the pericellular region of myofibroblasts in skin wounds with advanced wound age (6 weeks) further information for the time-estimation of older human skin lesions cannot be obtained. A semiquantitative analysis revealed no significant correlation between the number of positively stained cells and the wound age, rendering this parameter unsuitable for a practicable time-estimation of human wounds.
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  • 9
    ISSN: 1437-1596
    Keywords: Key words Cell death ; Apoptosis ; Wound age ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The time-dependent appearance of signs of cell death was investigated in human skin wounds using in situ end labeling of DNA fragments (ISEL). In the dermal layer an average of not more than 0.3 positively stained fibroblastic cells/0.01 cm × 0.01 cm was found up to a postinfliction interval of approximately 6 h. Average numbers exceeding 1 positive cell/0.01 cm × 0.01 cm were first detectable in a skin wound after 24 h. Therefore, average numbers greater than 1 labeled cell/ 0.01 cm × 0.01 cm indicate a postinfliction interval of approximately 1 day. An increase in the average number of positively stained cells occurred with increasing wound age. Values exceeding 3 cells/0.01 cm × 0.01 cm were first detectable 19 days after wound infliction. Accordingly, values of more than 3 labeled cells indicate a postinfliction interval of approximately 3 weeks or more. Since low numbers of labeled fibroblastic cells or even negative results were found in wounds of advanced age, only positive results provide information which can be useful for a forensic age estimation of human skin wounds.
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  • 10
    ISSN: 1437-1596
    Keywords: Immunohistochemistry ; Collagen IV and VII ; Basement Membrane ; Wound Age ; Immunhistochemie ; Kollagen IV ; Kollagen VII ; Basalmembran ; Wundalter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfasssung Es wurden 62 menschliche Hautwunden (Operationsnähte, chirurgisch versorgte Stich-und Riß-Quetsch-Wunden) untersucht. Neben Kollagen IV wurde in 27 Fällen zusätzlich Kollagen VII immunhistochemisch dargestellt. Es zeigte sich hierbei eine weitgehende Co-Verteilung von Kollagen IV und VII im Wundgebiet ohne daß relevante wundaltersabhängige Unterschiede bezüglich der Lokalisation im Bereich des Epithel-Defektes feststellbar waren. Basalmembran-Fragmente traten erstmals in 4 Tage alten Hautwunden auf. Frühestens 8 Tage nach Verletzung fanden wir eine komplette epidermale Basalmembran. Dies war in allen Präparaten mit einem Wundalter über 21 Tagen der Fall. Der Zeitraum zwischen dem B. und 21. Tag nach Wundsetzung war charakterisiert durch eine erhebliche Variabilität der Befunde mit teils kompletter, teils fragmentiert vorliegender, teils auch noch vollständig fehlender Basalmembran im Defekt-Bereich.
    Notes: Summary In 62 human skin wounds (surgical wounds, stab wounds and lacerations after surgical treatment) we analyzed the immunohistochemical localization of collagen IV in the epithelial basement membrane. In 27 of these wounds the distribution of collagen VII, which represents a specific component of the basement membrane of stratified epithelia, was also analyzed. We were able to demonstrate a virtually identical co-distribution of both collagen IV and VII in the wound area with no significant time-dependent differences in the appearance of both collagen types. Fragments of the epithelial basement membrane could be detected in the wound area from as early as 4 days after wounding and after 8 days a complete restitution of the epithelial basement membrane was observed. In all cases with a wound age of more than 21 days the basement membrane was completely reformed over the former lesional area. The period between 8 and 21 days after wounding was characterized by a wide variability ranging from complete restitution to deposition of basement membrane fragments or total lack of the epidermal basement membrane.
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