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  • 1
    ISSN: 1619-7089
    Keywords: Key words: Image registration ; Gamma camera ; Computerised tomography ; Positron emission tomography ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Scintigraphic diagnosis, based on functional image interpretation, becomes more accurate and meaningful when supported by corresponding anatomical data. In order to produce anatomical images that are inherently registered with images of emission computerised tomography acquired with a gamma camera, an X-ray transmission system was mounted on the slip-ring gantry of a GEMS Millennium VG gamma camera. The X-ray imaging system is composed of an X-ray tube and a set of detectors located on opposite sides of the gantry rotor that moves around the patient along with the nuclear detectors. A cross-sectional anatomical transmission map is acquired as the system rotates around the patient in a manner similar to a third-generation computerised tomography (CT) system. Following transmission, single-photon emission tomography (SPET) or positron emission tomography (PET) coincidence detection images are acquired and the resultant emission images are thus inherently registered to the anatomical maps. Attenuation correction of the emission images is performed with the same anatomical maps to generate transmission maps. Phantom experiments of system performance and examples of first SPET and coincidence detection patient images are presented. Despite limitations of the system when compared with a state of the art CT scanner, the transmission anatomical maps allow for precise anatomical localisation and for attenuation correction of the emission images.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 46 (1995), S. 413-416 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Sklerotisches Fibrom ; Cowden'sche Erkrankung ; Immunhistologie ; Key words Sclerotic fibroma ; Cowden's disease ; Immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The clinical and histological diagnosis of sclerotic fibroma is important because of its potential association with Cowden's syndrome. Despite its distinctive histological appearance the lesion is often misdiagnosed. We therefore present five of our own cases (2F, 3M) in which the tumor was located on the head (n=2), arm (n=2) and leg (n=1), respectively. Clinically, the lesions were white to flesh-colored firm nodules ranging in size from 0.5 to 1.2 cm. None of our patients revealed any clinical evidence of Cowden's disease. Simple surgical excision seems to be curative. Histologically, they were well-circumscribed but not encapsulated dermal nodules composed of storiform-arranged sclerosing collagen bundles and vimentin-positive fibroblastlike cells interspersed in three cases by a number of α-smooth-muscle actin-positive myofibroblasts. Approximately 50% of cells (dermal dendritic cells (DD)) also reacted for factor XIIIa evenly scattered throughout the lesion in contrast to the very few (〈5%) CD34+ DD found predominantly at the lower border, thus possibly reflecting the distribution of these cells in normal skin. Sclerotic fibroma expands the spectrum of fibrous lesions that may express α-smooth-muscle actin.
    Notes: Zusammenfassung Die klinische und histologische Diagnose sklerotischer Fibrome ist wegen ihrer potentiellen Assoziation mit der Cowden'schen Erkrankung von Bedeutung. Trotz ihrer distinkten histologischen Struktur bleibt die Läsion häufig fehlinterpretiert. Daher berichten wir über 5 eigene Patienten (2W, 3M), bei denen am Kopf (n=2), Arm (n=2) und Bein (n=1) entsprechende Tumoren beobachtet wurden. Die Läsionen imponierten klinisch als weiße bis fleischfarbene harte Knoten, die zwischen 0,5 und 1,2 cm maßen. Klinische Hinweise für das Vorliegen der Cowden'schen Erkrankung fanden sich bei keinem unserer Patienten. Die einfache chirurgische Exzision scheint kurativ zu sein. Histologisch waren die dermalen Tumoren gut umschrieben aber nicht abgekapselt und aus ineinander verflochtenen Kollagenfaserbündeln sowie fibroblastenähnlichen Zellen zusammengesetzt, bei 3 Patienten mit einigen Myofibroblasten. Ca. 50% der Zellen (dermale Dendrozyten (DD)) exprimierten zusätzlich Faktor XIIIa und waren gleichmäßig innerhalb der Tumoren verteilt, im Gegensatz zu den sehr wenigen (〈5%) CD34+ DD, die vor allem in den unteren Tumoranteilen beobachtet wurden. Diese Befunde mögen die Verteilung der DD in normaler Haut widerspiegeln. Das sklerotische Fibrom erweitert das Spektrum von Bindegewebstumoren mit potentiell myo-fibroblastischer Differenzierung.
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  • 3
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Morbus Hailey-Hailey – Humangenetik – Kopplungsanalyse – Bipolare affektive Erkrankung ; Key words: Hailey-Hailey disease – Human genetics – Linkage studies – Bipolar affective disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary. We report on three family members suffering from both autosomal dominant Hailey-Hailey disease and bipolar affective disorder. As molecular biology techniques have made the localization of genes causing simple Mendelian traits possible as a routine task, the gene for Hailey-Hailey disease will presumably be localized in the foreseeable future. The Hailey-Hailey gene and its chromosomal surrounding will then be a region of interest for linkage studies in bipolar affective disorder.
    Notes: Zusammenfassung. Wir berichten über eine Kosegregation von Morbus Hailey-Hailey (MHH) und bipolarer affektiver Erkrankung bei drei Mitgliedern einer Familie. Mit dem Fortschritt molekularbiologischer Techniken ist die Genlokalisation bei Erkrankungen mit einfachem Vererbungsmuster, wie dem autosomal-dominant vererbten MHH, eine Frage der Zeit. Die chromosomale Region des MHH-Gens wird dann auch Kandidatenregion für Kopplungsanalysen bei affektiven Erkrankungen sein.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 45 (1994), S. 324-329 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Chondroides Syringom – Aktin – Immunhistologie ; Key words: Chondroid syringoma – Actin – Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary. Chondroid syringoma belongs to the group of so-called mixed tumors, like pleomorphic adenomas of the lacrimal and salivary glands. The histogenesis of this tumour is still disputed, in particular with respect to its stromal component. The distribution of cytokeratins (CKs), CEA, EMA, vimentin, S-100 protein, desmin and actin [α-smooth muscle actin (α-SMA)] was investigated by immunohistological examination of paraffin sections from a chondroid syringoma of the apocrine type. The neoplastic formations have been classified into tubuloalveolar structures, solid nests/aggregations and stromal cells of varying morphology. The innermost cells of tubuloalveolar structures were characterized by marked expression of CKs (KL1 and MNF116), CEA and EMA, while in the outer ones there was moderate expression of vimentin, S-100 was expressed to a lesser extent and KL1, weakly but there was marked and consistent expression of MNF116. Whereas the solid nests expressed vimentin, S-100 protein, MNF116 markedly and KL1 weakly, the stromal cells were consistently positive for vimentin, S-100 protein and, focally, CKs and α-SMA. Anti-α-SMA specifically detects myoepithelial cells. In addition, the partly overlapping immunoreactivity of the intermediate filaments, membrane proteins and proteins in the different structures may indicate a common clonal origin of all neoplastic cells in chondroid syringoma.
    Notes: Zusammenfassung. Das chrondroide Syringom der Haut gehört wie das pleomorphe Adenom der Tränen- und Speicheldrüse zu den sogenannten Mischtumoren. Die Histogenese dieses seltenen Tumors wird kontrovers diskutiert, insbesondere hinsichtlich seiner stromalen Anteile. Die Verteilung von Zytokeratinen (CK), CEA, EMA, Vimentin, S-100 Protein, Desmin und Aktin (α-smooth muscle actin (α-SMA)) wurde immunhistologisch an Paraffinschnitten eines in toto exzidierten chondroiden Syringoms (Apokriner Typ) untersucht. Die neoplastischen Strukturen wurden hierzu in tubuloalveoläre Areale, solide Nester/Aggregationen sowie stromale Zellen unterschiedlicher Morphologie unterteilt. Die inneren Zellagen tubuloalveolärer Strukturen exprimierten ausgeprägt CK (KL1 und MNF116), CEA und EMA, die äußeren mäßig Vimentin, in geringerem Ausmaß S-100 Protein und schwach KL1, jedoch deutlich und regelmäßig MNF116. Während die soliden Nester deutlich positive Reaktionen für Vimentin, S-100 Protein, MNF116 und schwach für KL1 zeigten, exprimierten die stromalen Zellen intensiv und konstant Vimentin, S-100 Protein sowie fokal CK und α-SMA. Anti-α-SMA weist Myoepithelzellen spezifisch nach. Ferner könnte die teilweise überlappende Expression dieser Intermediärfilamente, Membranantigene und Proteine in den genannten Strukturen darauf hinweisen, daß alle neoplastischen Zellen chondroider Syringome einen gemeinsamen klonalen Ursprung haben.
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  • 5
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Epitheloidzelliges Histiozytom ; Immunhistologie ; Key words Epithelioid cell histiocytoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report on seven examples of this rare, only recently described benign tumor, which presented clinically as solitary elevated nodules on the lower (n=5) and upper (n=2) extremity, measuring between 0.6 and 1.1 cm in diameter. Histologically, all tumors were well-defined with a characteristic epidermal collarette. There were abundant (60–80%) epithelioid cells with prominent cytoplasm, a vesicular nucleus and inconspicuous nucleolus, as well as a number of dilated blood vessels. Immunohistologically, tumor cells did not react with monocyte/macrophage antibodies (KP1, MAC387). In addition, there was no evidence of myofibroblastic differentiation (alpha-smooth muscle actin and desmin negative). Thus, while immunohistological markers are helpful to exclude the diagnosis of other tumors, they do not shed light on the differentiation of epithelioid cell histiocytomas. The present cases are identical to those described originally. Recently similar lesions have been described in deeper parts of the corium as well as more cellular forms. Epithelioid cell histiocytoma represents a characteristic, poorly known variant within the spectrum of benign fibrous histiocytomas; it needs to be distinguished clinically and histopathologically especially from Spitz nevus.
    Notes: Zusammenfassung Wir berichten über sieben Beobachtungen dieses seltenen, erst kürzlich beschriebenen, gutartigen Tumors, der klinisch in allen Fällen als solitärer leicht erhabener Knoten von 0,6 bis 1,1 cm Durchmesser an der unteren (n=5) und oberen (n=2) Extremität imponierte. Histologisch zeigte sich in allen Fällen eine gut umschriebene Läsion mit charakteristischer epidermaler Manschette. Überwiegend (60–80%) epitheloide Zellen mit reichlich Zytoplasma, vesikulärem Kern und kleinem Nukleolus sowie zahlreiche erweiterte Blutgefäße kamen zur Darstellung. Diese Zellen reagierten nicht mit Monozyten/Makrophagen Antikörpern (KP1, MAC387). Auch fanden sich keine Hinweise für eine myofibroblastische Differenzierung (Alpha-smooth muscle actin und Desmin negativ). Mit Hilfe immunhistologischer Marker können daher andere Tumoren differentialdiagnostisch abgegrenzt werden, jedoch geben sie keine Information über die Differenzierung epitheloidzelliger Histiozytome. – Unsere hier präsentierten Fälle entsprechen der primär beschriebenen Variante. Kürzlich wurde auch über ähnliche Läsionen im tieferen Korium sowie zellreichere Formen berichtet. So stellt das epitheloidzellige Histiozytom eine charakteristische, bisher wenig bekannte Variante im Spektrum gutartiger fibröser Histiozytome dar, die klinisch und histopathologisch insbesondere vom Nävus Spitz abzugrenzen ist.
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  • 6
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
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  • 7
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The histogenesis of cutaneous local mucinosis (CFM) is controversial. Eleven cases of CFM (5F, 6M; mean age 51 years) from our routine files between 1986 and the present time have, therefore, been examined histopathologically and immunohistochemically. Histology revealed an increased number of fibroblast-like cells in early lesions, whereas they were diminished or predominantly at the margin in advanced ones. The myxomatous areas showed slight to absent reticulum formation. Similarly, elastic fibers were almost absent, and collagen fibers were fragmented and replaced by variable amounts of mucin. One specimen revealed an epithelial component within the lesion reminiscent of a poorly induced trichofolliculoma. Immunohistochemically, vimentin was consistently present and correlated with the number of fibroblast-like cells. A few (〈5%) CD34+ dermal dendritic cells (DDs) were locally seen within CFM. In contrast, FXIIIa+ DDs accounted for up to 30%. Fibroblasl-like cells were negative for S-100 protein, Leu7, desmin and α-SMA. The epithelial component within one of our specimens seems to have been induced by CFM and is a feature also seen in (angio)-myxomas. CFM appears to be a mesenchymally derived lesion composed predominantly of fibroblasts. DDs do not form the major cell component but rather seem passively incorporated.
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  • 8
    Publication Date: 2018-08-29
    Description: Sensors, Vol. 18, Pages 2834: Hand Tracking and Gesture Recognition Using Lensless Smart Sensors Sensors doi: 10.3390/s18092834 Authors: Lizy Abraham Andrea Urru Niccolò Normani Mariusz P. Wilk Michael Walsh Brendan O’Flynn The Lensless Smart Sensor (LSS) developed by Rambus, Inc. is a low-power, low-cost visual sensing technology that captures information-rich optical data in a tiny form factor using a novel approach to optical sensing. The spiral gratings of LSS diffractive grating, coupled with sophisticated computational algorithms, allow point tracking down to millimeter-level accuracy. This work is focused on developing novel algorithms for the detection of multiple points and thereby enabling hand tracking and gesture recognition using the LSS. The algorithms are formulated based on geometrical and mathematical constraints around the placement of infrared light-emitting diodes (LEDs) on the hand. The developed techniques dynamically adapt the recognition and orientation of the hand and associated gestures. A detailed accuracy analysis for both hand tracking and gesture classification as a function of LED positions is conducted to validate the performance of the system. Our results indicate that the technology is a promising approach, as the current state-of-the-art focuses on human motion tracking that requires highly complex and expensive systems. A wearable, low-power, low-cost system could make a significant impact in this field, as it does not require complex hardware or additional sensors on the tracked segments.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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