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  • 1
    Unknown
    Weinheim (Federal Republic of Germany) : VCH
    Call number: 05-BIO-30:11a ; 03-D:74A ; 01-SichIng:43
    Keywords: Cloning, Molecular ; Genetic Techniques
    Notes: Limited cataloging.
    Pages: xii, 454 p. : ill., ports.
    Edition: 2. durchgesehener Nachdruck 1985 der 1. Aufl. 1984.
    ISBN: 3527260617
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    05-BIO-30:11a departmental collection or stack – please contact the library
    03-D:74A departmental collection or stack – please contact the library
    01-SichIng:43 departmental collection or stack – please contact the library
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  • 2
    Unknown
    BERLIN U. A.: SPRINGER
    Call number: QP501Z:2/39
    Keywords: Protein / Struktur
    Notes: MOSBACH 1988: 14. -16. 4.
    Pages: X, 131 S.
    ISBN: 3-540-50394-3
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    QP501Z:2/39 available
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  • 3
    Unknown
    Weinheim ; New York, NY : VCH
    Call number: QH442:185
    Keywords: Cloning, Molecular / methods ; DNA, Recombinant
    Notes: Translation of: Gene und Klone.
    Pages: xiii, 634 p. : ill.
    ISBN: 3527266445
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    QH442:185 available
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  • 4
    Call number: QP501Z:2/43
    Keywords: DNA replication / Congresses ; Cell Cycle / congresses
    Pages: x, 266 p. : ill.
    ISBN: 3540547290
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    QP501Z:2/43 available
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  • 5
    Call number: QH442.2:21
    Keywords: Genetic Engineering ; Bioethics
    Pages: 21 p.
    ISBN: 3000063978
    Signatur Availability
    QH442.2:21 available
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  • 6
    ISSN: 1432-072X
    Keywords: Algae ; Heavy metal ; Glutathione ; Phytochelatin ; Sulfide ; Metallothionein ; Inducible Cd-binding complex ; Chlorella fusca
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A Cd-binding complex was isolated from Chlorella fusca and has been shown to be composed of phytochelating peptides, (γ-Glu-Cys) n -Gly, n=2–5. Members of six of the ten classes of Phycophyta revealed phytochelatin synthesis after exposure to cadmium ions. Phytochelatin was also induced by ions of lead, zinc, silver, copper and mercury. These experiments uneqiovocally demonstrated that algae sequester heavy metals by an identical mechanism as higher plants, namely via complexation to phytochelatins.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0570-0833
    Keywords: Creutzfeldt-Jakob disease ; gene technology ; prion protein ; protein-only hypothesis ; protein structures ; Creutzfeldt-Jakob disease ; Gene technology ; Prion protein ; Protein structures ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Prion diseases are currently in the spotlight. Among them, the Creutzfeldt-Jakob disease in humans, scrapie in sheep, and bovine spongiform encephalopathy, or mad cow disease, are most commonly known. The term “spongiform” refers to the characteristic appearance of the lesions found in affected brains. It is likely that prion diseases originate from a causative agent that replicates independently of nucleic acids. Current research assumes that a structural isoform of prion protein, the scrapie form PrPSc, is the responsible pathogen. The three-dimensional structure, but not the amino acid sequence of the isoform differs from that of the normal cellular isoform, PrPc. According to a widely accepted hypothesis, the normal isoform of the protein is converted by an autocatalytic process into the scrapie form upon contact with the latter. This hypothesis has not yet been proven. However, considerable progress has been made in the last few years, which might provide answers to many open questions about prion diseases, the subject of this review.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1040-452X
    Keywords: Ovary transfer ; Mice ; Transgenic offspring ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Female transgenic mice may be unable to reproduce successfully if the product encoded by the transgene results in pathological changes or affects the fertility of the mouse. To approach this problem, we have produced chimaeras by transferring the ovaries of transgenic mice into normal mice of the same strain. Such chimaeras will be an ideal tool for investigating the interactions between transgenic ovaries and normal mice or vice versa. Here we show that, using this method, we were able to get large numbers of transgenic offspring even from founder transgenic female mice that were themselves infertile as a result of the overexpression of growth hormone genes. Although none of the ovary recipients were given immunosuppressant treatment, 60% of the recipients had biologically active ovaries over a mean period of about 100 days.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0044-8249
    Keywords: Creutzfeldt-Jakob-Krankheit ; Gentechnik ; Prion-Protein ; Protein-only-Hypothese ; Proteinstrukturen ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Prion-Krankheiten, zu denen die Creutzfeldt-Jakob-Krankheit des Menschen, die Scrapie des Schafes (auch Traberkrankheit) sowie die spongiforme Encephalopathie des Rinds (der sogenannte Rinderwahnsinn) zählen, stehen derzeit im Brennpunkt des öffentlichen Interesses. Wegen des Aussehens der Läsionen im Gehirn spricht man auch von schwammartigen Encephalopathien. Prion-Krankheiten werden wahrscheinlich durch einen von Nucleinsäuren unabhängigen Erreger hervorgerufen. Nach dem gegenwärtigen Stand der Wissenschaft wird als Erreger eine strukturelle Isoform des Prion-Proteins angesehen, die Scrapie-Form PrPSc. Diese unterscheidet sich von der normalen zellulären Isoform PrPc nicht in der Aminosäuresequenz, vermutlich aber in der Raumstruktur. Nach einer weithin akzeptierten Hypothese wird die normale Isoform des Proteins bei Kontakt mit der Scrapie-Isoform in einer Art autokatalytischem Prozeß ebenfalls in die Scrapie-Form umgewandelt. Ein eindeutiger Beweis für diese Hypothese steht allerdings noch aus. Bei der Bearbeitung der vielen offenen Fragen zur Prion-Problematik wurden jedoch in jüngster Zeit bemerkenswerte Fortschritte erzielt, über die hier berichtet wird.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Directed exploitation of biological systems. During the past few decades, our knowledge of molecular process responsible for genetics has increased dramatically. Discovery of the giant molecule deoxyribonucleic acid - abbreviated as DNA - as the carrier of genetic information heralded in a development which nowadays permits us to effect directed changes in the genetic material of an organism. Thus we can provide easily cultured microorganisms with genes which were previously located in a completely different genetic environment. This helps us to obtain high yields of proteins or other substances which were formerly very difficult to obtain. Higher organisms such as animals and plants can also undergo modification of their genetic equipment. This adds a new dimension to the breeding of such species. Above all, genetic engineering provides new insights into the enormously complex interplay of molecules which go to make up a living cell. The resulting understanding of life processes on a molecular level permits recognition of malfunction and therapy of the ensuring disease by new drugs. In addition to these positive aspects, genetic engineering provides scope for conducting experiments whose ethical implications demand very earnest consideration.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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