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  • 1
    Call number: WL100:14
    Keywords: Seizures / classification
    Pages: xvi, 226 p.
    ISBN: 9780387173092
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    WL100:14 available
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  • 2
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Erythema ab igne ; Thermische Keratose ; Plattenepithelkarzinom ; Keywords Erythema ab igne ; Thermal keratosis ; Squamous-cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Erythema ab igne (EAI) is a red-brown netlike hyperpigmentation due to repetitive exposure to submaximal heat over a long period of time. This rash is typically seen on the anterior lower legs of people who sit in front of open fireplaces or coal stoves and on the trunk of patients with chronic disorders who seek pain relief by long-term use of hot-water bottles or heating pads. EAI can not only be a diagnostic sign for underlying internal diseases including malignant tumors but can also give rise to cutaneous malignancies. We report on a 75-year-old female patient who developed several thermal keratoses and squamous cell carcinomas at the site of erythema ab igne caused by chronic heat exposure over several years.
    Notes: Zusammenfassung Das klinische Bild des Erythema ab igne (EAI) ist charakterisiert durch eine rotbraune, netzartige Färbung der Haut, hervorgerufen durch wiederholte Exposition mäßiger Hitze über längere Zeiträume. Typische Lokalisationen des EAI sind die Streckseiten der unteren Extremitäten, bedingt durch das Sitzen vor offenen Feuerstellen oder Kohleöfen sowie der Stamm von Patienten mit chronischen Leiden, die zur Linderung ihrer Schmerzen regelmäßig Wärmeflaschen oder Heizkissen benutzen. Das EAI kann einerseits ein diagnostisches Zeichen zugrundeliegender innerer Erkrankungen einschließlich maligner Tumoren sein, andererseits kann es auch selbst Ausgangspunkt eines kutanen malignen Geschehens sein. Wir berichten über eine 75jährige Patientin, bei der es nach chronischer Wärmeexposition über mehrere Jahre zum Auftreten eines EAI und in weiterer Folge zur Entstehung von mehreren thermischen Keratosen und Plattenepithelkarzinomen in eben diesem Areal gekommen ist.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-041X
    Keywords: Development ; Lectin ; Neoglycoprotein Glycoconjugate ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Protein-carbohydrate interactions are supposed to play key roles in the mechanisms of cell adhesion, biosignalling and intracellular routing, warranting the analysis of the developmental course of expression of epitopes of this system. Thus, a panel of carrier-immobilized carbohydrate ligands was used as probes, namely lactose,N-acetylgalactosamine,N-acetylglucosamine, mannose, fucose and maltose. Additionally, an antibody to an endogenous β-galactoside-binding lectin (anti-galectin-1), the biotinylated lectin and two further human lectins, namely the macrophage migration inhibitory factor-binding sarcolectin and serum amyloid P component (SAP) that displays selectivity for sulphated sugars and mannose-6-phosphate, were included. They enabled us to assess the extent of the presence of respective binding sites in fixed sections from human lungs (pulmonary epithelial cells), livers (hepatocytes) and hearts (myocard cells) of 10–50 weeks gestation. Invariably, specific binding was detected in the three organ types, at least in certain stages. In most of the cases, the intensity of staining exhibited developmental regulation. The apparent patterns reveal similarities between the different cell types, as seen with immobilizedN-acetylglucosamine as well as with labelled galectin-1 and sarcolectin. However, drastic differences among such patterns with nearly opposite developmental courses do also occur, as detected for carrier-attached mannose and maltose residues. These results point to a potential importance for the detected glycohistochemical features in human development and substantiate the possibility of differential regulation of the presence of binding sites for distinct sugars within a certain organ and between the individual cell types of the monitored organs.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Cutaneous manifestations of B-cell chronic lymphocytic leukemia (B-CLL) comprise a wide spectrum of clinicopathologic presentations. In some cases, onset of skin lesions is triggered by antigenic stimulation, and specific skin infiltrates at sites of previous herpes simplex or herpes zoster infection have been well documented. Specific skin manifestations of B-CLL can also be observed at sites typical for lymphadenosis benigna cutis (nipple, scrotum, earlobe), a Borrelia burgdorferi-associated cutaneous B-cell pseudolymphoma.Methods:  We studied specific skin manifestations of B-CLL arising at sites typical for B. burgdorferi-induced lymphadenosis benigna cutis, analyzing tissues for presence of B. burgdorferi DNA using the polymerase chain reaction (PCR) technique. Six patients with B-CLL (M : F = 4 : 2; mean age: 67.8) presented with specific skin lesions located on the nipple (four cases) and scrotum (two cases).Results:  Clinically there were solitary erythematous plaques or nodules. Histology revealed in all cases a dense, monomorphous infiltrate of small lymphocytes showing an aberrant CD20+/CD43+ phenotype. In all cases monoclonality was demonstrated by PCR analysis of the JH gene rearrangement. PCR analysis showed in four of the six cases the presence of DNA sequences specific for B.burgdorferi.Conclusions:  Our study demonstrates that infection with B. burgdorferi can trigger the development of specific cutaneous infiltrates in patients with B-CLL.
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  • 5
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Ultraviolet (UV) light is an effective treatment for skin disorders like psoriasis in which the cutaneous neurosensory system may have a pathogenic role. In this study, we examined the possibility that UV modulation of the cutaneous neurosensory system and calcitonin gene-related peptide (CGRP) may contribute to local immunosuppression mediated by repeated subinflammatory UV irradiation. Our results indicated that exposure of hairless mice to subinflammatory UV three times weekly for 4 weeks significantly increased the number of epidermal nerve fibers (ENFs) immunoreactive for CGRP without altering the total number of ENFs. The skin content of CGRP as measured by enzyme-linked immunosorbent assay was also significantly increased after exposure to this dose of UV. These effects were most apparent 1 day after the last UV exposure and declined 1 week after UV. The role of CGRP in UV-induced immunosuppression of contact hypersensitivity was then examined. Our results indicated that UV suppression of epicutaneous 2,4-dinitro-1-fluorobenzene (DNFB) sensitization could be significantly inhibited by a systemically administered CGRP receptor antagonist. A broad-spectrum sunscreen applied before UV exposure inhibited increased cutaneous CGRP and blocked immunosuppression. These findings support a role for CGRP in the local immunosuppression caused by chronic, repeated subinflammatory UV exposure.
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  • 6
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
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  • 8
    ISSN: 1573-7322
    Keywords: Sarcomere structure ; cardiomyocyte ; pathophysiology ; proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a classification of the proteins of the cardiomyocyte based on structural and functional properties of the various components of this cell. The following protein families are categorized: 1) the contractile proteins, responsible for the contractile properties; 2) the sarcomeric skeleton, including titin, α-actinin, myomesin, M-protein, and C-protein, that keeps the contractile filaments in register and ensures sarcomeric stability; 3) the cytoskeletal proteins, i.e., desmin and the microtubules, that maintain the structural order within the cell and connect the cytoplasm and all cellular organelles with the sarcolemma; 4) membrane-associated proteins, such as vinculin, talin, dystrophin, and spectrin, that link the structural components of the intracellular milieu with those of the extracellular matrix via the integrins; and 5) proteins of the intercalated disc, including the cadherins, catenins, desmoplakin, connexin 43, and several others, that ensure stability of the longitudinal cardiomyocyte connections and facilitate impulse conduction. This classification not only is useful from a structural point of view but also is reflected in the functional behavior of these proteins in different pathophysiological situations, e.g., acute ischemia or chronic damage such as heart failure. Structural alterations, as shown here in human myocardium with chronic heart failure, demonstrate a graded sensitivity to pathophysiologic stimuli in that the contractile proteins are the most sensitive proteins and the cytoskeleton and the membrane-associated proteins show a compensatory increase and are more resistant against noxious stimuli. From these findings, it is concluded that these reactions to degenerative chronic processes reflect the survival priorities of the cells.
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  • 9
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 73 (1998), S. 2597-2599 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated the quantification properties of scanning capacitance microscopy (SCM) by using two dedicated test structures and highlight the response of SCM to changes in dopant density. Our results indicate that contrast reversal occurs and that the SCM output is not always a monotonically increasing signal with decreasing dopant density. Two epitaxially grown staircase structures covering the doping ranges 1014–1020 cm−3 p type and 5×1014–5×1019 cm−3 n type were produced for this study as the turning point in the response function typically occurs at a doping level of around 1017 cm−3. Through the use of a simple simulation model we see that contrast reversal is expected due to a relative shift between the dC/dV curves for different doping levels. The onset of contrast reversal can be adjusted by changing the dc sample bias leading to a shift in the operating position of the SCM, and the significance of this point will be discussed here. © 1998 American Institute of Physics.
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The use of minimally invasive techniques for cardiac surgery procedures has increased in the last 5 years. The term minimally invasive is used to describe cardiac procedures performed through a small incision or heart surgery performed without cardiopulmonary bypass. A review of the minimally invasive heart surgery literature is presented. According to the literature coronary bypass grafting without cardiopulmonary bypass can be carried out with similar early and mid-term results when compared to coronary bypass grafting with cardiopulmonary bypass. The same is true for LIMA to LAD bypass grafting performed through a lateral mini-thoracotomy. Controversial results are reported regarding morbidity after aortic and mitral valve surgery operated through a mini-incision. Some report less postoperative pain, earlier mobilization, shorter hospital stays, and lower costs. Others did not find any difference between full sternotomy and mini-incisions except a better cosmetic outcome. According to the literature there is no proven advantage of performing open heart surgery minimally invasively except in special situations, such as reoperation or polymorbid patients.
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