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  • 1
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds338 /20070906/
    Publication Date: 2007-09-07
    Keywords: human delta-5 and delta-6 desaturase ; FADS1 FADS2 gene cluster ; polyunsaturated fatty acids ; blood phospholipids ; red blood cell membranes ; Bavarian Nutrition Survey II ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds061 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
    ISSN: 0304-4165
    Keywords: (Human fibroblast) ; Insulin ; Lipogenesis ; Triiodothyronine ; dibutyryl cyclic AMP
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: acarbose ; diabetes mellitus ; carbohydrate tolerance ; fibre-free formula diet ; disaccharidase inhibition ; side-effects ; plasma insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of the disaccharidase inhibitor acarbose on carbohydrate tolerance was investigated in healthy subjects during substitution of fibre-free formula diets for normal food. Two separate experiments showed that acarbose was highly efficient in retarding and diminishing the postprandial rise in blood glucose and serum insulin when administered with these diets for 10 to 14 days. Acarbose decreased the area under the postprandial curves of blood glucose from 1.836 to −504 mg/dl×min in Study 1, and from 587 to −302 mg/dl×min in Study 2. The area under the serum insulin curves was reduced from 5.022 to 1.440 µU/ml×min in Study 1, and from 7.990 to 918 µU/ml×min in Study 2. In addition, acarbose greatly diminished the interindividual variation in postprandial serum insulin concentration. Its efficacy in reducing the glycaemic response to a test meal in both experiments was found to depend on the time of initiation of therapy; in contrast, the serum insulin response was only time-dependent in Study 2. Use of fibre-free diets to standardise experimental conditions proved to be a valuable tool in investigating these details.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary To examine the potential usefulness of restriction fragment length polymorphisms (RFLPs) for diagnosis of familial hypercholesterolemia (FH), we determined the genotype of FH patients and their relatives for the ApalI, NcoI, PvuII and StuI RFLP of the LDL-receptor gene in a sample of German patients attending the Lipid Clinic in Munich. There was no significant difference in the relative allele frequency between the group of FH patients and controls for any of the four polymorphisms. Using linkage analysis, we could determine the four-RFLP haplotypes of 39 defective and 90 normal LDL-receptor genes in 38 FH families. In our sample, defective LDL-receptor genes occur on 6 different chromosomes determined by the four RFLPs. This suggests that at least 6 different genetic defects may cause FH in this sample. RFLPs of the LDL-receptor gene cannot be used to detect FH in individuals; however, appropriate diagnosis can be carried out in more than 90% of families using linkage analysis and these RFLPs.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Familial hypercholesterolemia (FH) is caused by different mutations in the gene encoding the low density lipoprotein receptor (LDLR). In Caucasian patients, at least three single point mutations have been identified causing FH. The asparagine206 to glutamine, and valine408 to methionine mutations were originally described in Afrikaners and recently identified in Dutch FH patients. The proline664 to leucine mutations was previously identified in an FH homozygote of Asian Indian origin and later identified in patients from London. Any of these mutations can be identified using direct amplification of genomic DNA by the polymerase chain reaction (PCR) and restriction enzyme digestion of PCR products. In this study, 100 unrelated German FH patients were screened for these three mutations. The valine408 to methionine mutation was identified in one individual and subsequently in the hypercholesterolemic child of the proband. Haplotype analysis with 7 restriction fragment length polymorphisms (RFLPs) revealed that the mutant allele carried the same haplotype as the previously described patients in South Africa and the Netherlands. Our finding supports the previous assumption of the European origin of the mutation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 10 (1986), S. 33-37 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'alimentation parentérale totale représente une méthode capitale pour l'alimentation des malades soumis à des soins intensifs. A l'emploi des nutriments protéiques, des hydrates de carbone et de la graisse est venu s'ajouter récemment l'emploi des triglycérides à chaîne moyenne. Les avantages bien connus qu'ils présentent lors de l'alimentation entérale concernent également l'alimentation parentérale. Ils sont rapidement éliminés du sang, absorbés par les tissus extra-hépatiques, transportés indépendamment de la carnitine dans les mitochondries et oxydés plus rapidement que les acides gras à longue chaîne. Simultanément, les corps cétoniques formés au niveau du foie constituent une autre source d'énergie. Les triglycérides à chaîne moyenne en association avec les acides gras à longue chaîne sont une source d'énergie facilement disponible et ils exercent un effet stimulant sur le métabolisme protidique chez les opérés et les sujets victimes d'un traumatisme.
    Abstract: Resumen La nutrición parenteral représenta una medida muy importante como parte del tratamiento óptimo en pacientes de cuidado intensivo. Recientemente se ha extendido la administración de macronutrientes, proteína, carbohidratos y grasa, para incluir los triglicéridos de cadena media. Al mismo tiempo las bien conocidas ventajas de estas grasas en la alimentación enteral han sido confirmadas también para aplicación parenteral. Los triglicéridos de cadena media son rápidamente depurados de la sangre, captados por tejidos extrahepáticos, transportados mediante mecanismos independientes de la carnitina a las mitocondrias para ser oxidados más rápidamente que los ácidos grasos de cadena larga. La formación simultánea de cuerpos cetónicos en el hígado puede significar una fuente adicional de energía. Los triglicéridos de cadena media, en combinación con los ácidos grasos de cadena larga, administrados para atender la necesidad de ácidos grasos esenciales, provee energía fácilmente disponible y manifiesta un efecto de ahorro proteico en pacientes en estado postoperatorio o post-traumático.
    Notes: Abstract Total parenteral nutrition is an important measure in optimal treatment of patients under intensive care. Recently, the administration of macronutrients protein, carbohydrates, and fat has been extended to medium-chain triglycerides. Meanwhile, the well-known advantages of these fats in enteral feeding has also been confirmed for parenteral application. Medium-chain triglycerides are quickly removed from the blood, taken up by extrahepatic tissues, carnitine-independent transported into mitochondria, and oxidized more quickly than long-chain fatty acids. Simultaneously formed keton bodies from the liver may be an additional energy source. Medium-chain triglycerides, in combination with long-chain fatty acids for essential fatty acid supply, provide easily available energy and have a protein-sparing effect in patients after operation or injury.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1433-8580
    Keywords: Maltose ; perfused rat liver ; isolated hepatocytes ; glucose production
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The conversion of14C-maltose into glucose, lactate and14 CO2 was studied in perfused livers from fed and fasted rats and in isolated hepatocytes. Maximal glucose production was 30 mM x g−1 x h−1; half-maximal rates were found with 3 mM maltose. About 0.01 % of the radioactivity infused was recovered as14CO2. The addition of maltose had no effect on rates of oxygen consumption, lactate production or ketogenesis. The data suggest that maltose did not serve as a major substrate for biosynthetic or energy producing processes under the conditions of the perfused rat liver.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1433-8580
    Keywords: Human linoleic acid intake ; Liquid formula diets ; Prostaglandin metabolites in urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of linoleic acid intake on human prostaglandin formation was investigated by gas chromatographic determination of dimethyl tetranorprostanedioate, a derivative of the major urinary end products of prostaglandin metabolism. Six healthy female volunteers were put on liquid formula diets. Each person had a linoleic acid supply of 0, 10, and 50 g per day for periods of two weeks. At the end of these periods the corresponding average amounts of tetranorprostanedioic acid in urine were 92, 175, and 326 µg per day.
    Type of Medium: Electronic Resource
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