Springer Online Journal Archives 1860-2000
Abstract Methodologic studies were undertaken to establish the optimal conditions of continuous foot shock stimulation (3 min at 0.08 mA) for investigating drug effects on distress-evoked behavior, e.g., vocalizing, leaping, running, fighting and recovery latencies. The drugs subsequently studied under these conditions (imipramine, methamphetamine, methadone, perphenazine, pentobarbital, ethyl alcohol and chlordiazepoxide) could be distinguished and classified from the profiles of action obtained. Greatest overall reduction of the distress-evoked behaviors in diminishing order were produced by perphenazine, methadone, ethyl alcohol and chlordiazepoxide. Methadone most selectively reduced leaping responses; perphenazine most selectively prolonged recovery time latencies. None of the agents reduced fighting at doses that did not also modify the other modes of responding.
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