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  • 1
    ISSN: 1432-2307
    Keywords: Rheumatoid arthritis ; Muscle changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Muscle changes were studied in biopsy material obtained from 100 patients suffering from classical rheumatoid arthritis. The abnormalities consisted of denervation atrophy of type II muscle fibres, degenerative changes in the sarcoplasm including presence of nemaline rods, and changes within the interstitium: namely perivascular nodular myositis, lymphocytic accumulations, different stages of vasculitis and abnormalities within the intramuscular nerves and muscle spindles. The muscles examined were always severely affected. It is considered that the simultaneous presence of these abnormalities is suggestive of rheumatoid arthritis. The importance of histochemical studies is emphasized. The literature concerning muscle changes in rheumatoid arthritis is reviewed.
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  • 2
    ISSN: 1432-2307
    Keywords: Rheumatoid arthritis ; Muscle spindles ; Neuromuscular spindles ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural features of muscle spindles were studied in biopsy material from 100 patients suffering from classical rheumatoid arthritis. Thickening of the outer capsule, increased amount of extracellular ground substance within the inner capsule, and marked thickening of the basement membrane of capillary blood vessels supplying the muscle spindles were observed. Chronic inflammatory cells and macrophages were present within the spindles. Changes affecting the intrafusal muscle fibres were also seen. They were manifest as atrophy and degeneration of the intrafusal muscle fibres, absence of the specialised junctional complexes, and of the intercellular bridges, microladders and satellite cells. It is suggested that the changes affecting the intrafusal muscle fibres are probably secondary. Damage to the myelinated nerves was present, while the sensory and motor nerve endings were well preserved.
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  • 3
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Autoren beschreiben 6 Fälle von „Zapfenepiphyse“. Sie beobachteten diese eigenartige enchondrale Ossifikationsstörung nach Dyschondroplasie, enchondraler Dysostose, Osteomyelitis und nach Frakturen der Epiphyse. Auf Grund der beschriebenen Fälle und experimentellen Beobachtungen sehen die Autoren die Ursache des Entstehens dieser Deformität in einer Kreislaufstörung im Gebiete der epiphysären und nutritiven Hauptarterie. Das Weiterwachsen des peripheren Teils des Wachstumsknorpels wird durch die periosteale und perichondrale Blutversorgung gesichert. Das mit der Deformität verknüpfte Zurückbleiben im Wachstum hängt vom Grad der enchondralen Ossifikationsstörung bzw. Verletzung ab.
    Notes: Summary Six cases of “cone-shaped epiphysis” are reported. This is a special disorder of the enchondral ossification; it was observed in cases of dyschondroplasia, enchondral dysostosis also following osteomyelitis and fractures near the epiphysis. On the basis of experimental and clinical observations authors believe, that the deformity develops in consequence of the disturbance of the circulation in the epiphyseal vessels and in the main nutrient artery. Blood supply to the peripheral area of the growth-plate for it's further growth originates from the perichondral and periosteal vessels. Eventual arrest of growth depends on the severity of the disturbance of the ossification, respectively on the severity of the trauma.
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  • 4
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Verfasser fanden keine Wachstumsstörung, die von anderen angenommen war, am distalen Tibiaende bei einem Modellexperiment der kongenitalen Unterschenkelpseudarthrose.
    Notes: Summary Authors could not confirm a growth disturbance—suggested by other workers—at the distal end of the tibia in a modell experiment of congenital pseudarthrosis of the leg.
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  • 5
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Verfasser berichten über ein Modellexperiment der kongenitalen Unterschenkelpseudarthrose, die eine periostale Hypertrophie imitiert.
    Notes: Summary Authors report on a modell-experiment of the congenital pseudarthrosis of the leg, which is imitating the role of a periosteal hypertrophy.
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