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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2018); 20181023-20181026; Berlin; DOCGF23-412 /20181106/
    Publication Date: 2018-11-07
    Keywords: chondrogene Differenzierung ; Knorpelmatrix ; Sphäroidkultur ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; VOL: 2; DOC097 /20060424/
    Publication Date: 2006-04-24
    Description: Die konfokale Laser Scanning Microscopy (LSM) liefert Informationen aus Epitheltiefen bis 0,5 mm. Ziel dieser ex vivo-Pilotstudie war es, die Anwendbarkeit dieser Methode für die Diagnostik des Kehlkopfkarzinoms und seiner Vorstufen zu prüfen.Die Untersuchungen wurden an 43 Larynxpräparaten von 26 Patienten (Alter: 35 bis 61 Jahre, durchschnittliches Alter: 51,9 ± 9,5 Jahre; 7 Frauen und 19 Männer), die sich im Zeitraum von Februar bis November 2005 einer Mikrolaryngoskopie wegen Larynxschleimhautveränderungen jedweder Genese unterzogen haben, vorgenommen. Die LSM-Befunde (Videos und Einzelbilder) wurden mit denen gesunder Larynxepithelien (Voruntersuchungen) und den histologischen Befunden verglichen. Folgende Kriterien wurden zur Charakterisierung der Malignität herangezogen: Vergrößerte und unterschiedlich geformte Zellen, Zellkluster, erhöhte Kern-Plasma-Relation, irreguläre Zellarchitektur, Verlust der Zellgrenzen.Die LSM ermöglicht die Darstellung der Basalzellschicht des Stimmlippenepithels, des Reincke-Raumes, des subepithelialen Raumes sowie dessen Gefäße. Ferner läßt sich das respiratorische Epithel der Supraglottis abgrenzen.Unter Verwendung der festgelegten Malignitätskriterien wurde für die Differenzierung von Dysplasie und benignen Tumoren vom Karzinom eine Sensitivität von 72.7% und eine Spezifität von 82,9% ermittelt. Mit der LSM wird eine Eindringtiefe bis zum subepithelialen Raum erreicht. Eine Differenzierung zwischen Entzündung, Dysplasie und Karzinom ist möglich. Die LSM stellt eine neue Technologie dar, die für den in vivo-Einsatz vorbereitet wird.
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS); 20160922-20160924; Hamburg; DOC16dgnnP02 /20160914/
    Publication Date: 2016-09-14
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.; 20060524-20060528; Mannheim; DOC06hnod383 /20060424/
    Publication Date: 2006-04-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The local cerebral glucose utilization (LCGU) was measured in the different areas and layers of the Ammon's horn and dentate gyrus of young adult (3 to 4-month-old) rats, and of 27-month-old rats with proven cognitive deficits. The LCGU was determined by quantitative [14C]2-deoxyglucose autoradiography. Compared to young animals, in the old rats the LCGU was significantly reduced by 12% to 15% in the oriens layers of CA1 and CA2, the pyramidal layers of the CA sectors 1–3, the radiatum and lacunosum-molecular layers of CA2 and CA3 and in the lucidum layer of CA3. The LCGU values of all the other layers of the Ammon's horn and the dentate gyrus did not differ significantly between young and old rats. The pattern of the LCGU reduction found in the old rats roughly resembles changes found after fimbra-fornix lesions or systemic administration of scopolamine, suggesting a functionally important deficit in the cholinergic innervation of the old rats' hippocampi.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The local cerebral glucose utilization (LCGU) was measured in 63 different cortical areas and nuclei of the telencephalon, diencephalon and rhombencephalon of young adult (3 to 4-month-old) rats and of 27-month-old Wistar rats, in which learning impairments had been proven by a water maze test. The LCGU was determined by [14C]2-deoxyglucose autoradiography. In the old rats the mean LCGU of all brain regions was significantly reduced by about 10% compared with the young control group; the mean LCGU was 74.2 μmol glucose/(100 g × min) in the young and 66.7 in the old rats. Different degrees of LCGU decrease were found in the different regions. Most of the brain regions with significantly reduced LCGU values in the aged, learning impaired rats were associated with auditory and visual functions, the dopaminergic system, and structures known to be involved in learning and memory processes. Therefore, the regional pattern of LCGU reduction found in the aged, learning impaired rats did not resemble any known pattern found after lesions of a single transmitter system or systemic administration of transmitter agonists or antagonists.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The local cerebral glucose utilization (LCGU) was measured in different regions and layers of the Ammon's horn and dentate gyrus in the conscious rat. The LCGU was determined by quantitative [14C]2-deoxyglucose autoradiography using a computerized image processing system. In the hippocampus, the various regions and layers exhibited different glucose consumptions, the lowest values being found in the alveus and the highest ones in the lacunosum-molecular layers of the dentate gyrus' external limb. Additionally, in many layers, the LCGU values of the left hemispheres were found to be higher compared with the right hemispheres. The analysis of LCGU changes in rostrocaudal direction revealed, that in sector 1 of Ammon's horn and in the dentate gyrus the glucose consumption decreased from rostral to caudal levels, whereas in sector 3 of Ammon's horn an increase was found.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the adult mammalian brain, the energy metabolism is almost entirely dependent on glucose. Furthermore, a close relationship between the energy metabolism and the functional activity could be shown. Thus, the functional activity of the brain or parts thereof can be quantified by measuring the cerebral metabolic rate for glucose. Studying in vivo the fate of a radioactive labeled analogue of glucose, the 2-deoxy-d-[1-14C]glucose, and using quantitative autoradiographic techniques, it is possible to estimate the cerebral glucose utilization of every discrete brain region. The advantage of the 2-deoxyglucose method is, that the local cerebral glucose utilization represents a “metabolic encephalography” (Sokoloff 1982).
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By means of the [14C]-2-deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in 41 brain regions in autoimmune New Zealand Black (NZB) mice and in Carworth Farm Winkelmann (CFW) mice, which served as the control strain. At the age of 6 months, the mean LCGU of all measured areas and brain stem nuclei was 67.7 μmol glucose/(100 g x min) in the nonautoimmune CFW mice. These LCGU values are within the limits published by other observers. In contrast, in the aged-matched NZB mice the glucose use was markedly reduced, the mean LCGU of all measured areas being 37.7 μmol glucose/(100 g x min). These findings suggest that the immunological, morphological and behavioural abnormalities in the aged NZB mouse correlate with a reduced functional activity of the central nervous system, measured as reduced cerebral glucose utilization.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0568
    Keywords: Pars cerebellaris loci coerulei ; Man ; Neuronal loss ; Aging ; Biomathematical analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pars cerebellaris loci coerulei is a flat accumulation of perikarya representing a subnucleus of the locus coeruleus in the roof of the fourth ventricle of the brain in man. A quantitative study was done on this subnucleus; it comprised 67 specimens from individuals between 11 and 90 years. Nerve cell counts were performed on cleared mounted block preparations. Mathematical analysis of the data was performed using logistic growth functions. The results showed that with advancing age there is a loss of neurons in both sexes. This begins in the female approximately after age 40; in the male already at age 20 (reaching a lower value in old age). The final loss of neurons is more pronounced in the male than in the female. Male and female specimens did not differ in the total number of neurons. In both sexes the left side of the pars cerebellaris loci coerulei contained more neurons than the right.
    Type of Medium: Electronic Resource
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