Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1613-9674
    Keywords: MR imaging ; Submandibular masses ; Submandibular gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tumor-like swellings in the submandibular region were evaluated in seven patients with MR imaging. Two cases of pleomorphic adenoma and two of sialoadenitis were selected as examples of submandibular gland lesions, while a plunging ranula, dermoid cyst and lymphadenitis were selected as examples of extraglandular lesions. The pleomorphic adenoma was connected with the remaining gland on T1-weighted images. The sialoadenitis showed changes in the size, signal intensity and homogeneity of the submandibular gland itself. On the other hand, extragland lesions showed zonal interpositions between the lesion and the submandibular gland, which showed either low or high signal intensity on T1-weighted images. On T1-weighted images, the intensity of all of the lesions was either lower than or the same as the normal submandibular gland. On the other hand, all lesions showed higher signal intensity, ranging from slight to very high on T2-weighted images. Sharp margins were seen in all lesions except one sialoadenitis. The sialoadenitis showed inflammatory infiltration into the surrounding tissue. A homogeneous internal pattern was observed in the case of cystic lesions, while an inhomogeneous internal pattern was noted in the pleomorphic adenoma and in the inflammatory lesions. Gd-DTPA enhanced the T1-weighted images in three cases. Pleomorphic adenoma and lymphadenitis were enhanced inhomogeneously, whereas the ranula was not enhanced.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1613-9674
    Keywords: Bone scintigraphy ; 99m-Tc HMDP scintigraphy ; Mucoepidermoid tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Bone scintigraphy with 99m-Tc HMDP was investigated for its pathological basis in a patient with mucoepidermoid carcinoma in the right molar region of the mandible. An accumulation of 99m-Tc HMDP was remarkable in the bone surrounding the tumor. There were large numbers of osteoblasts and a large increase in the amount of osteoid tissue which lined most of the surface of the immature woven bone. The result of our investigation suggested that the concentration of 99m-Tc HMDP was not tumor specific in itself and mostly depend on production of reactive immature new bone. The bone scintigraphic finding was necessary to be interpreted according to the pathological basis.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1613-9674
    Keywords: Eosinophilic granuloma ; Osteomyelitis ; Malignant neoplasm ; Scintigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An eosinophilic granuloma was discovered in the region of the ramus of the mandible. This case occured in a very rare location limited only to the ramus, and showed similar features resembling osteomyelitis or malignant neoplasm at different stages of the disease. The radiographic findings indicated a diagnosis of malignant neoplasm and the scintigraphic manifestations showed that of osteomyelitis. The histopathological examinations showed different manifestations in accordance with the respective stages of the disease. This case was finally diagnosed as eosinophilic granuloma showing rapid regression.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thrombomodulin (TM) is a glycoprotein originally isolated from rabbit lung vasculature and characterized as a natural endothelial anticoagulant. Thrombin binds to TM noncovalently with high affinity. Thrombin - TM complexes can activate protein C efficiently. Activated protein C inactivates factors Va and VIIIa and regulates the blood coagulation cascade. Thus TM converts thrombin from a procoagulant protease to an anticoagulant. TM is found on endothelial cells in veins, arteries and capillaries. Our previous study has shown that TM is also expressed on the cell surface of squamous epithelium. In the present study, we aimed to disclose differences in TM expression among normal, dysplastic, and malignant squamous epithelium in human oral mucosa by counting TM-positive cells in each lesion. TM was uniformly expressed in the spinous layer of normal human oral squamous epithelium. The number of TM-positive cells was not significantly different between normal epithelium, lichen planus and mild dysplasia. In contrast, in moderate and severe dysplasia and well-differentiated squamous cell carcinoma (SCC), there were significantly fewer positive cells compared with normal epithelium. In SCCs, the periphery and the central keratinized area of tumor islands were often negative. The proportion of TM-positive cells in poorly differentiated SCC was significantly lower than in well-differentiated SCC. These results indicate that TM may have diagnostic value in the histological examination of oral premalignant and malignant lesions.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thrombomodulin (TM) is a glycoprotein that was originally identified on vascular endothelium and characterized as a natural endothelial anticoagulant. We reported previously that TM was also expressed at cell-cell boundaries of squamous epithelium, except in the basal layer cells and upper granular layer cells. The expression pattern of TM in the squamous cells implies that this molecule might be associated with keratinocyte differentiation, as well as being a potent anticoagulant. In the present study we examined TM expression immunohistochemically in biopsy specimens from 65 patients with primary oral squamous cell carcinoma (OSCC). and compared the results with the biological behavior of the carcinomas. The patients with intense TM expression in the carcinoma showed a significantly lower frequency of lymph node metastasis and significantly more favorable survival than those with negative TM expression. The TM expression was a better marker than the other prognostic factors, such as differentiation degree, tumor size and invasion mode. When TM expression was compared between the primary and metastatic lesions in the 36 patients who had lymph node metastasis, 14 (39%) showed decreased TM expression. 19 (53%) showed no change, and 3 (8%) showed an increase in the metastatic lesions. Wilcoxon's signed-rank test indicated that tumor cells positive for TM expression were significantly rarer in the metastatic lesions than in the primary tumors (P〈0.05). These results indicate that reduced expression of TM is associated with metastasis of carcinoma cells. The reduction of TM expression seems to play an important role in the metastatic process of OSCC, and to be related with a poor outcome for the patients.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...