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  • 1
    Unknown
    London, England : Harvey Miller Publishers
    Call number: QZ241.2:4
    Keywords: Cancer / Cytodiagnosis ; Tumors / Cytodiagnosis ; Neoplasms / diagnosis ; Neoplasms / pathology ; Tumor / Histologie ; Tumor / Atlas
    Pages: 812 p. : col. ill.
    ISBN: 0192618407
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  • 2
    ISSN: 1432-2277
    Keywords: Liver transplantation ; Aspiration cytology ; Rejection ; Fine needle aspiration ; Total corrected increment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of aspiration cytology (AC) and the total corrected increment (TCI) in the diagnosis of hepatic rejection was assessed in 30 patients following 36 liver transplants. A total of 174 AC specimens were “blindly” evaluated. Patients underwent protocol AC twice weekly and when biochemical or clinical parameters suggested rejection. Hepatic rejection was only confirmed when clinical and biochemical changes were accompanied by positive histological diagnosis. In all, 103 specimens were matched against histology, the remainder assessed against retrospective clinical and biochemical diagnoses. There were 80 cytological diagnoses of rejection, confirmed in 69 specimens, and 94 diagnoses of no rejection, confirmed in 73 specimens. These figures give a sensitivity of 76.7%, a specificity of 86.9% and a positive predictive value of 86.3%. Overall, 39.7% of specimens taken more than 2 months after grafting proved to be incorrectly diagnosed. However, the accuracy was higher in 145 specimens taken within 8 weeks of transplantation, with a sensitivity of 81.3%, a specificity of 90%, a positive predictive value of 89.7% and an accuracy of 85.5%. Although histology remains the gold standard in the diagnosis of acute rejection after hepatic grafting, AC using a TCI with a positive predictive value of 86.3% may prove to be of value in monitoring liver transplant patients in the first 2 months after grafting.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The interaction between the T cell receptor (TCR) and its cognate antigen/major histocompatibility complex (MHC) complex activates a cascade of intracellular protein phosphorylations within the T cell. The signals are initiated by the specific phosphorylation of two tyrosine residues located in a conserved sequence motif termed an ITAM (immune receptor-based tyrosine activation motif). There are 10 ITAMs in the TCR complex, and 6 of these ITAMs are present in the TCR ζ homodimer. Following TCR stimulation, the TCR ζ subunit forms two tyrosine-phosphorylated intermediates of 21- and 23-kDa, respectively. The dramatic and diverse biological responses of T cells are proposed to be partly regulated by the relative ratios of the 21- vs. 23-kDa phosphorylated forms of TCR ζ that are induced following TCR ligation. In this review, we describe a stepwise model of ζ phosphorylation required for the formation of these two phosphorylated derivatives. We describe the kinases and phosphatases controlling these phosphorylation processes. In addition, we present some preliminary findings from ongoing studies that discuss the contributions of each phosphorylated form of ζ on T cell development, TCR signaling, T cell anergy induction, and T cell survival.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 56 (1997), S. 210-220 
    ISSN: 0006-3592
    Keywords: ribonucleic acids ; transcription ; optimization ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: RNA molecules are commonly produced in vitro by transcription, utilizing a DNA template, an RNA polymerase enzyme, and nucleoside triphosphate substrates (NTPs). In addition to the full-length RNA molecule coded for by the DNA template, significant amounts of shorter RNA molecules are produced. A simplified model of this complex transcription process is presented, with the shorter RNA molecules lumped into a single pool. The rate equations do not depend on the stoichiometry of the RNA molecule of interest, which facilitates application of the model to other RNA molecules. Optimal initial conditions for batch in vitro RNA transcription to produce a dodecamer RNA containing three different nucleotides have been predicted using the model. The predicted optimal values for equimolar NTPs are 10 to 15 mM initial concentration for each NTP and 50 to 60 mM for magnesium acetate, yielding a maximum final dodecamer concentration of 0.8 ± 0.1 mM at the 90% confidence interval. Experimental data agree well with the model results. © 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 56: 210-220, 1997.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Polymerization rate, glass transition temperature, storage modulus, molecular weight between crosslinks and heterogeneity of the final polymer product were studied as a function of the crosslinking agent concentration for several multifunctional methacrylates. The goal of this study was to determine the effect of crosslinking monomer structure and concentration on the rates of polymerization and mechanical properties of the polymer. A series of copolymers with equal concentrations of crosslinking double bonds was prepared using a monomethacrylate plus a di- or trimethacrylate. The trimethacrylate systems had higher glass transition temperatures, larger storage moduli, and smaller molecular weights between crosslinks than the comparable dimethacrylate systems. However, the heterogeneity of the trimethacrylate systems was found to be much more extensive. Additionally, the maximum rate of polymerization was found to increases with increasing crosslinking agent when octyl methacrylate was used as the monomethacrylate, but passed through a maximum when 2-hydroxyethyl methacrylate was used. The relative rates of polymerization between the trimethacrylate and dimethacrylate systems also depended on the monomethacrylate employed and the concentration of the crosslinking agent.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2991
    Keywords: sustainable ; development ; education ; international ; commission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This paper explores the role of education as it might assist in achieving a sustainable world. It examines the perceptions of the international community present at the seventh session of the Commission on Sustainable Development (CSD). A survey was conducted of 146 delegates and UN staff over the two weeks of the Commission's session in April 1999. The survey identified the primary importance placed on education as a cross-cutting theme of sustainability and the need for efforts to be co-ordinated to achieve education for sustainable development at all levels. To make further progress for implementing Agenda 21, the task management by UNESCO must improve through instigation of a supportive reporting system at the CSD. The education community must receive appropriate support and funding to make effective progress at local and national levels to implement the work programme for education, public awareness and training.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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