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  • 1
    Keywords: Medicine ; Oncology ; Microbiology ; Bacteriology ; Biomedicine ; Cancer Research ; Microbiology ; Bacteriology ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: 〈p〉Preface.-℗ The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis.-℗ The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminths and Fungi in Cancer Development.-℗ Organ Microbiota in Cancer Development: the Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?́€‹〈/p〉́€&#x2039
    Abstract: 〈p〉Over the years of cancer investigation a lot of discoveries in this field were made, and many associations between various biological carcinogens and cancer were revealed. Some of them are credibly determined, thus these infectious agents (human papilloma virus, hepatitis B virus, hepatitis C virus, Epstein-Barr virus, human herpes virus 8, human T-cell lymphotropic virus 1, human immunodeficiency virus, Merkel cell polyomavirus, Helicobacter pylori, Opisthorchis viverrini, Clonorchis sinensis, Schistosoma haematobium) are recognized as carcinogens and probable carcinogens by International Agency for Research on Cancer (IARC). The problem is of large importance, since share of infectious agents-related cancer cases is steadily increasing, reaching 25% according to certain estimates. It is worth noting that many of cancer cases are caused by infectious agents other than ℗±conventional ones℗» like HPV, EBV, HBV, HCV, H.pylori etc. In recent years, a number of significant breakthroughs in the field were performed, such as the discovery of the microbiota role in cancer causation. Here in this book, almost all connections between ℗±unconventional℗» carcinogenic infectious agents and cancer are described and analyzed comprehensively. The monograph was written with the idea that the language and concept will be rather simple and understandable for the wide audience, but the information contained in the book will be useful even for researchers working in the field of biological carcinogenesis who are familiar with the problem. Infectious Agents and Cancer may also be helpful for PhD, graduate and undergraduate students of biomedical faculties, and for their lecturers as well. The main idea of this book is to attract the attention to the problem of infectious agents causing human cancer other than the known biological carcinogens. 〈/p〉〈p〉℗ 〈/p〉
    ISBN: 9789400759558
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  • 2
    Keywords: Medicine ; Immunology ; Microbiology ; Medical virology ; Biomedicine ; Virology ; Immunology ; Medical Microbiology ; Springer eBooks
    Description / Table of Contents: The Hypothesis of Virus-Driven Atherosclerosis -- The Role of Herpes Simplex Virus-1 and Herpes Simplex Virus-2 in Atherosclerosis -- How may HSV promote atherosclerosis? -- Evidence from epidemiological studies -- Evidence from cardiovascular events -- The Role of Epstein-Barr virus in Atherosclerosis -- EBV and atherosclerosis: the published data from basic and epidemiological investigations -- The Role of Enteroviruses, Parvovirus B19, Respiratory Syncytial Virus and Measles Virus in Atherosclerosis -- Enteroviruses -- Parvovirus B19 -- Respiratory Syncytial Virus (RSV) -- Measles Virus -- The Role of Hepatitis A, B, and C in Atherosclerosis -- Hepatitis A virus (HAV), atherosclerosis, and related diseases -- Hepatitis B virus (HBV), atherosclerosis, and related diseases -- Hepatitis C virus (HCV), atherosclerosis, and related diseases -- HCV and changes in immunological and atherotic profile -- HCV and subclinical atherosclerosis -- HCV and CAD -- HCV and myocardial infarction -- HCV and stroke -- Conclusions -- Summaries: Are We There Yet?
    Abstract: Will address an important, yet underrepresented, topic. The correlation between viruses and atherosclerosis has been a focal point of the authorś€™ work, for a number of years. This volume will explore the relationship between different viral strains and ℗ atherosclerosis. It will begin by describing the hypothesis and denoting the mechanisms of virus-driven atherosclerosis, then expanding on the subject by focusing on different virus strainś€”from Herpes, to Epstein-Barr, to the triad of Hepatitis viruses, et al€”ón a chapter-by-chapter basis. While there are books, albeit few, that cover particular viral strains and their relationship to cardiovascular diseases, this work will be unique in its scope by considering multiple strains of viruses, making it a repository of information on the topic; a truly comprehensive volume
    Pages: X, 69 p. 1 illus. : online resource.
    ISBN: 9781461488637
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  • 3
    Keywords: Life sciences ; Oncology ; Human Genetics ; Immunology ; Cardiology ; Cell receptors ; Life sciences ; Receptors ; Immunology ; Cancer Research ; Human Genetics ; Oncology ; Cardiology ; Springer eBooks
    Description / Table of Contents: The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go
    Abstract: This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed
    Pages: XI, 185 p. 2 illus., 1 illus. in color. : online resource.
    ISBN: 9783034806886
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Hygiene and Infection Control; VOL: 9; DOC16 /20140819/
    Publication Date: 2014-08-20
    Description: Aim: During the last decade it became obvious that viruses belonging to Mimiviridae and Marseilleviridae families (order Megavirales), may be potential causative agents of pneumonia. Thus, we have performed a review of the association of Mimiviridae , Marseilleviridae , and virophages with pneumonia, particularly healthcare-associated pneumonia, and other infections of the respiratory tract. Results and discussion: According to the analysis of the published articles, viruses belonging to Mimiviridae family can be potential agents of both community-acquired and healthcare-associated pneumonia. In particular, these viruses may be associated with poor outcome in patients of intensive care units. The exact mechanism of their pathogenicity, however, still remains unclear. The discrepancies between the results obtained by serological and genomic methods could be explained by the high polymorphism of nucleotide sequences of Mimiviridae family representatives. Further investigations on the Mimiviridae pathogenicity and on the determination of Mimiviridae -caused pneumonia risk groups are required. However, the pathogenicity of the viruses belonging to Marseilleviridae family and virophages is unclear up to now.
    Description: Zielsetzung: Im letzten Jahrzehnt wurde vermutet, dass Viren der Familie der Mimiviridae und der Marseilleviridae (sog. Megavirales) Pneumonien verursachen können. Deshalb wurde eine Literaturrecherche zu den möglichen Zusammenhängen von Mimiviridae , Marseilleviridae , Virophagen und Pneumonien mit den Schwerpunkten HA-Infektionen und andere Infektionen der Atemwege durchgeführt. Ergebnisse und Diskussion: Die Analyse ergab, dass Viren aus der Familie der Mimiviridae potentielle Verursacher sowohl der CA- als auch der HA-Pneumonie sein können. Diese Viren können zu einem verschlechterten Outcome bei Intensivtherapiepatienten führen. Der genaue Mechanismus ihrer Pathogenität ist jedoch noch immer nicht geklärt. Die unterschiedlichen Ergebnisse zwischen serologischen und Genommethoden sind wahrscheinlich durch den hohen Polymorphismus der Nucleotidsequenzen der Vertreter der Mimiviridae zu erklären. Daher sind weitere Untersuchungen zur Pathogenität der Mimiviridae und ihrer Rolle bei der Pneumonieentstehung in Risikogruppen notwendig.Im Unterschied dazu ist die Pathogenität der Viren der Familie der Marseilleviridae und der Gruppe der Virophagen noch unklar.
    Keywords: mimivirus ; mimiviridae ; marseilleviridae ; giant viruses ; virophages ; pneumonia ; healthcare-associated infections ; Mimivirus ; Mimiviridae ; Marseilleviridae ; Riesenviren ; Virophagen ; Pneumonie ; Healthcare-assoziierte Infektionen ; ddc: 610
    Language: English
    Type: article
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  • 5
    Publication Date: 2018-01-24
    Description: A core matrisome gene signature predicts cancer outcome A core matrisome gene signature predicts cancer outcome, Published online: 23 January 2018; doi:10.1038/bjc.2017.458 A core matrisome gene signature predicts cancer outcome
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
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