Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Proceed order?

Export
  • 1
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  Mainz//2011; 56. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 6. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi); 20110926-20110929; Mainz; DOC11gmds202 /20110920/
    Publication Date: 2011-09-20
    Keywords: phytoestrogens ; serum enterolactone ; postmenopausal breast cancer ; survival ; prognosis ; ddc: 610
    Language: English
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: RECEPTOR ; CANCER ; tumor ; BLOOD ; Germany ; COHORT ; cohort studies ; cohort study ; EXPOSURE ; RISK ; TUMORS ; ASSOCIATION ; BREAST ; breast cancer ; BREAST-CANCER ; DESIGN ; WOMEN ; CLINICAL-TRIALS ; PROSPECTIVE COHORT ; REDUCED RISK ; DIET ; nutrition ; ER ; ESTROGEN-RECEPTOR ; HETEROGENEITY ; POSTMENOPAUSAL WOMEN ; case-control study ; ASSOCIATIONS ; PHYTO-ESTROGENS ; SERUM ENTEROLACTONE CONCENTRATION ; ESTROGEN ; estrogen receptor ; prospective ; CANCER-RISK ; SUBGROUPS ; PLASMA ENTEROLACTONE ; DIETARY PHYTOESTROGEN INTAKE ; breast cancer risk ; CYP17 GENOTYPE ; ESTROGEN-RECEPTOR STATUS ; FLAVONOID INTAKE ; MAMMALIAN LIGNANS
    Abstract: Background: Epidemiologic studies that examined whether lignans, the most important class of phytoestrogens in the Western diet, protect against breast cancer have yielded inconsistent results. Objective: In this study, we conducted meta-analyses on the association between lignans and breast cancer risk. Design: We performed a systematic MEDLINE search to identify epidemiologic studies published between 1997 and August 2009. We calculated pooled risk estimates (REs) for total lignan exposure, dietary lignan intake, enterolignan exposure, and blood or urine concentrations of enterolactone and according to menopausal and estrogen receptor (ER) status of tumors. Results: We included 21 studies (11 prospective cohort studies and 10 case-control studies) in the meta-analyses. Lignan exposure was not associated with an overall breast cancer risk (RE: 0.92; 95% CI: 0.81, 1.02; P for heterogeneity = 0.004). However, in postmenopausal women, high lignan intake was associated with a significant reduced risk of breast cancer (13 studies; RE: 0.86; 95% CI: 0.78, 0.94; P for heterogeneity = 0.32). Breast cancer risk was also inversely associated with enterolignan exposure (4 studies; RE: 0.84; 95% CI: 0.71, 0.97) but not with blood or urine enterolactone concentrations. The associations were not significantly different between ER-status subgroups (6 studies). Conclusions: High lignan exposure may be associated with a reduced breast cancer risk in postmenopausal women. Additional work is warranted to clarify the association between lignan exposure and breast cancer risk. Am J Clin Nutr 2010; 92: 141-53
    Type of Publication: Journal article published
    PubMed ID: 20463043
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: MYOCARDIAL-INFARCTION ; OXIDATIVE STRESS ; BREAST-CANCER RISK ; CARDIOVASCULAR-DISEASE ; PHYSICAL-ACTIVITY ; NO ASSOCIATION ; PERIPHERAL-BLOOD CELLS ; PARKINSONS-DISEASE PATIENTS ; OLDEST-OLD ; SHORTER TELOMERES
    Abstract: OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients. RESULTS: Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r=-0.338, p〈0.0001) and relative LTL (r=-0.295, p=0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91 BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5 BP/year). CONCLUSION: While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.
    Type of Publication: Journal article published
    PubMed ID: 23333817
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: CANCER ; POPULATION ; WOMEN ; METASTASIS ; XENOGRAFTS ; FOODS ; PLASMA ENTEROLACTONE ; lignan ; FLAXSEED ; MAMMARY-TUMOR GROWTH ; OIL COMPONENTS ; PHYTOESTROGEN CONTENT
    Abstract: Purpose Lignans-plant-derived compounds with estrogen-dependent and -independent anticarcinogenic properties-have been associated with postmenopausal breast cancer risk, but data are limited regarding their effect on survival. Dietary lignans are metabolized to enterolignans, which are subsequently absorbed and become bioavailable. Patients and Methods We assessed the prognosis of 1,140 postmenopausal patients with breast cancer age 50 to 74 years who were diagnosed between 2002 and 2005. Vital status through the end of 2009 was ascertained via local population registries, and deaths were verified by death certificates. Information on recurrences and secondary tumors was verified by clinical records and attending physicians. Associations of postdiagnostic serum enterolactone (a biomarker for dietary lignans) with overall survival and distant disease-free survival were assessed by using Cox proportional hazards models stratified by age at diagnosis and adjusted for prognostic factors. Results Median enterolactone levels for deceased patients and those still alive were 17.0 and 21.4 nmol/L, respectively. During a median of 6.1 years of follow-up after diagnosis, 162 deaths were confirmed. Higher serum enterolactone levels were associated with significantly reduced hazard ratios (HRs) for death (HR per 10 nmol/L increment, 0.94; P = .04; HR for the highest quartile, 0.58; 95% CI, 0.34 to 0.99). For distant disease, HR was 0.94 per 10 nmol/L increment (P = .08) and 0.62 (95% CI, 0.35 to 1.09) for the highest quartile. The highest quartile of serum enterolactone was associated with a significantly reduced risk of death only for estrogen receptor-negative tumors (HR, 0.27; 95% CI, 0.08 to 0.87) but not for estrogen receptor-positive tumors (HR, 0.91; 95% CI, 0.45 to 1.84: P for heterogeneity = .09). Conclusion Postmenopausal patients with breast cancer who have high serum enterolactone levels may have better survival.
    Type of Publication: Journal article published
    PubMed ID: 21900115
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: CANCER ; RISK ; METABOLISM ; BIOMARKERS ; ASSOCIATION ; BREAST ; BREAST-CANCER ; WOMEN ; OBESITY ; BREAST-CANCER RISK ; POSTMENOPAUSAL WOMEN ; MASS INDEX ; SERUM ; IGF-I ; ESTROGEN ; STEROID-HORMONES ; BINDING GLOBULIN ; CIRCULATING LEVELS ; C-PEPTIDE ; HEALTHY WOMEN ; sex ; FREE TESTOSTERONE
    Abstract: Being overweight or obese increases the risk of postmenopausal breast cancer. A potential reason may be the frequently observed positive association of BMI with endogenous sex hormones and its negative association with sex hormone-binding globulin (SHBG). The purpose of this study was to investigate whether a woman's body fat distribution shows a BMI-independent association with these breast cancer-related biomarkers. Performing cross-sectional analyses among 1,180 postmenopausal women, we assessed whether associations of surrogates for an abdominal (waist circumference; waist-to-hip ratio, WHR) and gluteofemoral (hip circumference) fat distribution with estrone, total and free estradiol, androstenedione, total and free testosterone, and SHBG changed after adjustment for, or stratification by, BMI. All anthropometric measures were positively associated with estrogens and free testosterone, and negatively with SHBG. After adjustment for BMI, associations of free-estradiol, free testosterone, and SHBG with both waist circumference and WHR remained significant, but all initially significant associations with hip circumference were abolished. In stratified analyses, waist circumference and WHR correlated with free estradiol, free testosterone, and SHBG in women with a BMI 〈 30 kg/m(2) but not in women with a BMI 30 kg/m(2). The latter suggests that in obese women, a possibly unique effect of abdominal fat on these biomarkers may be masked by the already large amount of overall body fat. On the whole, our results indicate that waist circumference and WHR, but not hip circumference, are associated with SHBG and SHBG-related sex hormones (free estradiol and free testosterone) independently of BMI
    Type of Publication: Journal article published
    PubMed ID: 22240723
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Keywords: ASSOCIATION ; breast cancer ; prevention ; LIGNANS ; POSTMENOPAUSAL WOMEN ; PHYTO-ESTROGENS ; ENTEROLACTONE ; PLASMA ENTEROLACTONE ; TIME-RESOLVED FLUOROIMMUNOASSAY ; DAIDZEIN ; genistein ; DIETARY PHYTOESTROGENS ; ISOFLAVONOID PHYTOESTROGENS
    Abstract: Lignans are a group of estrogenic compounds present in plants. Several epidemiological studies proposed that lignans may protect against breast cancer by exerting anticarcinogenic activity. Levels of enterolactone were determined in serum samples of 1,250 cases and 2,164 controls from a large population-based case-control study. We assessed the association between serum enterolactone and postmenopausal breast cancer risk using conditional logistic regression accounting for potential risk and confounding factors. Fractional polynomials were used to determine the function that best fitted the data. Moreover, we assessed heterogeneity by estrogen/progesterone/herceptin (ER/PR/HER2) status of the tumor. Additionally, a meta-analysis with seven further studies addressing enterolactone concentrations and breast cancer risk was performed. Postmenopausal breast cancer risk decreased with increasing serum enterolactone levels [highest compared to lowest quintile: [odds ratio = 0.65; 95% confidence interval (CI) 0.52-0.83, p(trend) = 〈0.0001]. A significant inverse association for ER+/PR+ as well as ER-/PR- tumors was observed, with a significantly stronger association for ER-/PR- tumors (p(heterogeneity) = 0.03). The association for ER-/PR- tumors did not differ by expression of HER2 (p(heterogeneity) = 0.3). The meta-analysis yielded a significant reduced pooled risk estimate of: 0.66; 95% CI: 0.55-0.77) comparing the highest to the lowest quantiles of enterolactone levels. We found strong evidence for a significant inverse association between serum enterolactone and postmenopausal breast cancer risk, which was stronger for ER-PR- than for ER+PR+ tumors but not differential by further expression of HER2. The overall evidence together with other studies supports an inverse association between higher serum enterolactone levels and postmenopausal breast cancer risk.
    Type of Publication: Journal article published
    PubMed ID: 21544804
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Keywords: POPULATION ; prevention ; WOMEN ; RECEPTOR STATUS ; SOY ISOFLAVONES ; SECOISOLARICIRESINOL ; LARICIRESINOL ; METAANALYSES ; MATAIRESINOL ; PINORESINOL
    Abstract: Phytoestrogens are structurally similar to estrogens and may affect breast cancer risk by mimicking estrogenic/antiestrogenic properties. In Western societies, whole grains and possibly soy foods are rich sources of phytoestrogens. A population-based case-control study in German postmenopausal women was used to evaluate the association of phytoestrogen-rich foods and dietary lignans with breast cancer risk. Dietary data were collected from 2,884 cases and 5,509 controls using a validated food-frequency questionnaire, which included additional questions phytoestrogen-rich foods. Associations were assessed using conditional logistic regression. All analyses were adjusted for relevant risk and confounding factors. Polytomous logistic regression analysis was performed to evaluate the associations by estrogen receptor (ER) status. High and low consumption of soybeans as well as of sunflower and pumpkin seeds were associated with significantly reduced breast cancer risk compared to no consumption (OR = 0.83, 95% CI = 0.70-0.97; and OR = 0.66, 95% CI = 0.77-0.97, respectively). The observed associations were not differential by ER status. No statistically significant associations were found for dietary intake of plant lignans, fiber, or the calculated enterolignans. Our results provide evidence for a reduced postmenopausal breast cancer risk associated with increased consumption of sunflower and pumpkin seeds and soybeans.
    Type of Publication: Journal article published
    PubMed ID: 22591208
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
  • 9
    Keywords: CANCER-RISK ; journals ; Postmenopausal breast cancer risk ; breast cancer risk ; HEALTH ; Jun ; cancer risk ; BREAST-CANCER ; breast cancer ; BREAST ; case-control study ; LIGNANS ; RISK ; CANCER
    Type of Publication: Meeting abstract published
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Abstract: OBJECTIVES: To investigate associations between physical activity and endogenous sex hormones after menopause with a special focus on confounding and effect modification by body mass index (BMI). METHODS: A cross-sectional study among 1,260 postmenopausal women was conducted. Generalized linear models were used to compare levels of total leisure-time physical activity, sports activities, bicycling, and walking with levels of sex hormones and sex-hormone-binding-globulin (SHBG). RESULTS: Higher sports activity levels were significantly associated with lower levels of estrone and total and free testosterone in multivariate adjusted models. After additional adjustment for BMI, associations with estrone and free testosterone were attenuated; the association with total testosterone remained unchanged. No physical activity variable was significantly related to total and free estradiol, androstenedione, or SHBG. We did not observe effect modification by BMI. CONCLUSIONS: Sports activities may lead to lower levels of estrone and testosterone in postmenopausal women. While effects on estrone and free testosterone seem to be largely mediated by BMI, effects on total testosterone appear to be mainly independent of BMI. The BMI-independent effects on these hormones (especially on total testosterone) could at least partly explain why physical activity has been frequently reported to be preventive for postmenopausal breast cancer, even after accounting for BMI.
    Type of Publication: Journal article published
    PubMed ID: 21052816
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...