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  • 1
    ISSN: 1573-7446
    Keywords: bronchus ; colonization ; lymph gland ; goat ; Pasteurella haemolytica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty goats of about 7 months of age were divided into five groups. The goats in groups 1 and 2 were exposed once, using an intranasal spray to 2 ml of an inoculum containing 106 colony-forming units/ml of living or dead Pasteurella haemolytica A2, respectively. The goats in groups 3 and 4 were similarly exposed twice at a 2-week interval. Group 5 was the untreated control. The number and size of the bronchus-associated lymphoid tissue (BALT) in goats exposed twice to either living or dead organisms were significantly (p〉0.05) increased compared with those exposed once and with the unexposed control. In vitro colonization by living P. haemolytica A2 onto the lung tissue in which the BALT had been stimulated by two exposures of either living or dead organisms was significantly (p〉0.05) reduced. The study indicates that stimulation of the respiratory mucosal immunity may prevent P. haemolytica A2 infection.
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  • 2
    ISSN: 1573-7446
    Keywords: alveolar septa ; endothelium ; epithelium ; lung ; Pasteurella multocida ; pneumocytes ; rabbits ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen 8- to 9-week-old Pasteurella multocida-free rabbits were divided into two equal groups. Eight rabbits in one group were inoculated intranasally with P. multocida type A:3. The other eight were inoculated intranasally with phosphate-buffered saline and used as controls. Nasal swabs taken before and after inoculation were cultured for bacterial isolation. Post-mortem nasal swabs and lung samples were cultured for bacteriological isolation. Nasal mucosa and lung samples were collected and processed for transmission electron microscopy. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits and from the lungs of four infected rabbits. Degenerative ultrastructural changes in epithelial cells and endothelial cells were seen in the infected rabbits. Deciliation of the cilated epithelium and hyperplasia of the goblet cells in the nasal mucosa were noted. Thickening of the alveolar septa due to hyperplasia of type II pneumocytes, swelling of the endothelial lining of capillaries and infiltration of inflammatory cells were also observed. Intracellular invasion of the nasal epithelial cells and of type II pneumocytes by the organism was observed. Coccobacilli were observed in membrane-bound vacuoles in the cytoplasm of these cells. The vacuoles were adjacent to the host-cell mitochondria and some of these vacuoles appeared to be fused to the mitochondrial membrane. Some type I pneumocytes with intracellular membrane-bound vacuoles containing bacterial cells showed protrusions, which appeared to detach into the alveolar lumina. These results indicated that P. multocida serotype A:3 in rabbits can invade the epithelial cell and cause structural changes in the interstitium, epithelium and endothelium. Heterophils and macrophages appear to play important roles in tissue injury.
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  • 3
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 4
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 5
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Douze chèvres âgées de près de 3 mois ont été réparties entre 4 groupes égaux. Les chèvres des groupes 1 et 2 ont été infectées avec les virus ORF, suivi d'une infection àCorynebacterium pyogenes chez les groupes 1 et 3, trois jours après la première apparition des lésions dues au virus ORF. Les chèvres du groupe 4 représentaient le groupe témoin non-infecté. Des complications deux aux lésions ORF formées de croûtes purulentes et suintantes tout autour des lèvres ont été observées chez les chèvres du groupe 1. Les lésions ont persisté 24 jours, mais ont surtout été graves du 8e au 13e jour. Les chèvres du groupe 2 ont développé des lésions typiques de l'infection par virus ORF qui ont persisté pendant 10 jours, tandis que les chèvres du groupe 3 ont développé de petits nodules d'environ 1 cm de diamètre, 48 jours après l'inoculation deC. pyogenes qui ont duré 6 jours seulement. Aucune lésion n'a été remarquée chez les chèvres du groupe 4. Deux chèvres due groupe 1 atteintes d'ORF avec complications sont mortes après 16 et 22 jours respectivement.
    Abstract: Resumen Se formaron 4 grupos de cabras de 3 animales cada uno, con una edad aproximada de 3 meses. Las cabras de los grupos 1 y 2 se infectaron con el virus del ectima contagioso. A los 3 días de la aparición de las lesiones de ectima contagioso los grupos 1 y 2 se infectaron conCorynebacterium pyogenes. Las cabras del grupo 4 sirvieron de controles no infectados. Los animales del grupo 1 presentaron lesiones complicadas de ectima contagioso que consistían en escaras humedas y supurativas y que cubrian todos los labios. Las lesiones persistieron 24 días, siendo mas graves desde el día 8 al 13. Las cabras en el grupo 2 desarrollaron lesiones típicas de ectima contagioso que duraron 10 días, mientras que las del grupo 3 desarrollaron pequeños nódulos de cerca de 1 cm de diámetro 48 horas despues de la infección porC. pyogenes que persistieron solo 6 días. No se observaron lesiones en las cabras del grupo 4. Dos cabras del grupo 1 con ectima contagioso murieron a los 16 y 22 días respectivamente.
    Notes: Summary Twelve goats about 3 months of age were divided into 4 equal groups. Goats in Groups 1 and 2 were infected with orf virus followed byCorynebacterium pyogenes infection of Groups 1 and 3, 3 days after the first appearance of orf lesions. Goats in Group 4 were uninfected controls. Complicated orf lesions which consisted of wet suppurative scabs around the entire lips were observed in goats in Group 1. The lesions persisted for 24 days but were most severe from days 8 to 13. Goats in Group 2 developed lesions typical of orf virus infection that lasted 10 days, while goats in Group 3 developed small nodules of about 1 cm diameter, 48 hours following the introduction ofC. pyogenes, which persisted for only 6 days. No lesion was observed in goats in Group 4. Two goats in Group 1 with complicated orf died after 16 and 22 days respectively.
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  • 6
    ISSN: 1573-7446
    Keywords: BALT ; bronchus ; dexamethasone ; goat ; IgA ; lymphocytes ; Pasteurella haemolytica A2 ; pneumonia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A trial was conducted to observe the immediate and chronic effects in goats of dexamethasone administration on the bronchus-associated lymphoid tissue (BALT) response to intranasal administration of formalin-killed Pasteurella haemolytica A2. Twenty-four goats were divided into four groups. Those in group 1 were injected intramuscularly with 1 mg/kg dexamethasone on three consecutive days, followed by intranasal exposure to formalin-killed P. haemolytica A2 one day after the last dexamethasone treatment. The goats in group 2 were similarly injected with dexamethasone followed by intranasal exposure to formalin-killed P. haemolytica A2 21 days after the last dexamethasone treatment. The animals in group 3 were exposed intranasally to formalin-killed P. haemolytica A2 without prior dexamethasone treatment. The animals in group 4 were untreated controls. The intranasal exposures to formalin-killed P. haemolytica A2 were repeated 2 weeks later. Intranasal exposure to formalin-killed P. haemolytica 1 day after dexamethasone treatment further reduced the number and size of BALT compared to the untreated control. Significantly (p〈0.01) more reduction of BALT occurred in goats exposed to formalin-killed P. haemolytica A2 21 days after dexamethasone treatment. On the other hand, intranasal exposure of goats without prior dexamethasone treatment stimulated the BALT compared to the untreated controls.
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  • 7
    ISSN: 1573-7446
    Keywords: concurrent disease ; goats ; haemonchosis ; pasteurellosis ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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