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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  128. Kongress der Deutschen Gesellschaft für Chirurgie; 20110503-20110506; München; DOC11dgch181 /20110520/
    Publication Date: 2011-05-20
    Keywords: ddc: 610
    Language: German
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2014); 20141028-20141031; Berlin; DOCPO17-698 /20141013/
    Publication Date: 2014-10-14
    Keywords: ddc: 610
    Language: German
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); 20131022-20131025; Berlin; DOCPO11-802 /20131023/
    Publication Date: 2013-10-24
    Keywords: Wirbelsäule ; Minimalinvasiv ; iSYS-1 ; C-Arm Computertomographie ; ddc: 610
    Language: German
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch4905 /20060502/
    Publication Date: 2006-05-09
    Keywords: ddc: 610
    Language: German
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  • 5
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    German Medical Science; Düsseldorf, Köln
    In:  123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch5491 /20060502/
    Publication Date: 2006-05-09
    Keywords: ddc: 610
    Language: German
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  • 6
    ISSN: 1432-2102
    Keywords: Schlüsselwörter LITT ; Laserablation ; MR-Thermometrie ; Key words Laser ; MR thermometry ; LITT ; Liver cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary MR-guided LITT (laser-induced thermotherapy) is currently being evaluated for its effectiveness in clinical oncology. MR-guided LITT is defined as a minimally invasive technology based on the effects of the applied Nd-YAG laser on tumorous tissue. Due to specific characteristics of the laser-induced coagulative effect, online monitoring via MR thermometry is possible and extremely precise. In a period of 6 years 335 patients suffering from malignant soft tissue tumors were prospectively treated via MR-guided LITT. We evaluated the local tumor control rate, the rate of complications and the survival data from the clinical and MRI follow-up. Our results prove that MR-guided LITT results in a extremely low rate of side effects and an effective tumor control rate higher than 95%, depending on the size of the lesion. It is concluded that this therapeutic concept is of clinical value for patients with primary and secondary liver cancer, malignant lymph node involvement, abdominal recurrent tumors and tumors of the head and neck.
    Notes: Zusammenfassung Die interventionelle MR-gesteuerte laserinduzierte Thermotherapie (LITT) wird derzeit klinisch und im Rahmen prospektiver Studien bei unterschiedlichen onkologischen Fragestellungen eingesetzt und evaluiert. Per definitionem stellt die MR-gesteuerte laserinduzierte Thermotherapie ein minimalinvasives Therapieverfahren dar, das auf der Laserwirkung mit resultierendem koagulativen Effekt beruht. Der thermoablative Effekt wird dabei „online”überwacht und dokumentiert durch den Einsatz spezieller MR-Sequenzprotokolle. Innerhalb eines Zeitraums von 6 Jahren wurden dabei prospektiv 335 Patienten mit malignen Weichteiltumoren therapiert und die Tumorortskontrollrate, die Komplikationsrate sowie die Überlebensdaten evaluiert. Die gewonnenen Ergebnisse zeigen, daß die MR-gesteuerte LITT ein nebenwirkungsarmes Therapieverfahren darstellt, mit einer enorm hohen Präzision und einer Tumorortskontrollrate bei optimierter Technik von 〉95%. Als Indikationen werden vorgestellt die Thermotherapie von primären und sekundären Lebermalignomen, sekundärer Lymphknoteninvasionen, abdomineller Rezidivtumoren sowie Tumorfragestellungen in der Kopf-/Halsregion.
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  • 7
    ISSN: 1433-0393
    Keywords: Key words Livermetastases • Breast carcinoma • ; Laser induced thermotherapy • Minimally invasive therapy ; Schlüsselwörter Lebermetastasen • Mammakarzinom • Laserinduzierte Thermotherapie • Minimal-invasive Therapien
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen der hämatogenen Metastasierung des Mammakarzinoms stellt die Leber ein häufig betroffenes Organ dar. Im Falle eines isolierten Befalls der Leber werden bei fehlendem Ansprechen auf Chemo- und Hormontherapie im Einzelfall lokal sanierende Maßnahmen wie die chirurgische Resektion oder auch minimal-invasive Verfahren wie Tumorablationen diskutiert. Im Rahmen eines klinischen Programms wurden daher prospektiv 51 Patienten mit sekundär metastatischem Befall der Leber bei Mammakarzinom mittels MR-gesteuerter laserinduzierter Thermotherapie in Lokalanästhesie therapiert. Die mittels MR-gesteuerter LITT erzielte lokale Tumorkontrolle in der Leber lag in der 3-Monats-Kontrolle bei 98,2 %, in der 6-Monats-Kontrolle bei 97,1 %. Die mittlere Überlebensrate, berechnet ab Diagnosestellung der gelaserten Metastase betrug 50,29 (95-%-Konfidenzintervall (KI) 41,99–58,59) Monate. Berechnet ab dem Tag der Laserbehandlung betrug die mittlere Überlebensrate 36,31 (95-%-KI 30,40 – 42,22) Monate. Die LITT erlaubt heute eine hohe lokale Tumorkontrollrate; mögliche Indikationen liegen bei Patienten mit primär hepatischer Metastasierung, bei denen trotz Chemo- und Hormontherapie residuelle Lebermetastasen nachgewiesen werden oder diese progredient sind.
    Notes: Summary The liver is one of the most involved organs in the case of hematogenous metastases of breast carcinoma. In strictly intrahepatic involvement of breast cancer local ablative methods like surgical resection and minimal-invasive treatment modalities are discussed when systemic chemo- or hormone therapies are ineffective. In the clinical programme 51 patients with secondary metastastic involvement of the liver due to breast carcinoma were prospectively treated via MR-guided laser-induced thermotherapy in an outpatient setting. Patients were included with a maximum of five lesions up to a maximum diameter of 5 cm. Patients with additional extrahepatic involvement are excluded. MR-guided LITT allowed local tumor control in the liver at three months of 89.2 % and at six months of 79.1 %. The cumulative median survival rate was 50,29 months (confidence interval 95 %, 41.99–42.22 months). MR-guided LITT allows high local tumor control. Possible indications for the treatment with LITT are patients with strictly intrahepatic metastases who are not demonstrating a complete response after chemo- or hormone therapy.
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  • 8
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  To investigate uterotubal transport by means of hysterosalpingoscintigraphy (HSSG) in women with and without endometriosis.Design  A prospective observational study.Setting  University Hospital, Department of Obstetrics and Gynaecology, Division of Reproductive Medicine and Gynaecologic Endocrinology with 350 in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) cycles and 400 intrauterine insemination (IUI) cycles/year.Population  Cases included 56 infertile women with laparoscopic proven endometriosis and patent fallopian tubes. Twenty-two women with partners suffering from male factor infertility served as controls.Methods  A diagnostic cycle incorporating HSSG was performed. Subsequently, patients underwent either four cycles of timed intercourse (TI) or IUI in order to achieve pregnancy. If pregnancy did not occur, IVF or ICSI was performed.Main outcome measures  Evaluation of uterotubal transport capacity in women with endometriosis and healthy controls.Results  Patients suffering from endometriosis (group I) showed a significant reduction in physiologic uterotubal transport function: While 20 patients (36%) had ipsi- or bilateral uterotubal transport, there was pathological uterotubal transport contralateral to the dominant follicle or a complete failure of transport capacity (negative HSSG) in 36 patients (64%). In the controls (group II), transport function was significantly different: 15 of 22 patients (68%) revealed ipsi- and bilateral tubal demonstration, while 5 patients (22%) showed contralateral transport and 2 patients (10%) showed negative HSSG (P= 0.01). Twenty-three pregnancies were observed (pregnancy rate: 29%). Eleven out of 14 (79%) women with ipsi- or bilateral tubal transport function fell pregnant by means of TI or IUI. In seven of nine patients (78%) with a failure in tubal transport, pregnancy was achieved by IVF/ICSI, despite acceptable semen parameters (P= 0.01).Conclusions  Endometriosis is significantly associated with a reduction in physiologic uterotubal transport capacity compared with controls. This resulted in diminished pregnancy rates even in women with normozoospermic partners. Therefore, IVF/ICSI may be required even when fallopian tubes are patent or semen quality is normal.
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