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  • 1
    Keywords: Stem Cells ; Ophthalmology ; Stem Cells ; Regenerative Medicine/Tissue Engineering ; Ophthalmology ; Springer eBooks
    Description / Table of Contents: Advantages of the Eye as a Target Organ for Cell-Based Therapy in the Central Nervous System -- Proof of Principle: Preclinical Data on Retinal Cell Transplantation -- Clinical and Pathological Features of Selected Human Retinal Degenerative Diseases -- Degenerative Retinal Diseases: Cells sources for cell-based therapy -- Manufacturing of Clinical Grade Cellular Products Under Gmp Conditions -- Regulatory Requirements for Cell-Based Therapy for Degenerative Retinal Disease -- Biomaterials and Scaffolds for Cell Replacement Therapy -- Restoration of cone photoreceptor function in retinitis pigmentosa (RP) – retinal cell-based therapy -- Cell Delivery: Surgical Approaches -- Diagnosis and Complementary Examinations -- Cell Therapy for Degenerative Retinal Disease: special focus on cell fusion-mediated regeneration -- Clinical Trials of Retinal Cell Therapy -- Future Directions -- Index
    Abstract: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology
    Pages: XI, 280 p. 27 illus., 20 illus. in color. : online resource.
    ISBN: 9783030052225
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The synaptosomal transport of fourteen different neurotransmitters, neurotransmitter precursors and other amino acids was tested for a chloride dependence. Those compounds having sodium-dependent‘high-affinity’transport systems exhibited a chloride dependence which was maintained over time and which was concentration dependent. Low chloride concentrations altered the transport kinetics of the compounds examined. The reduced accumulation of these compounds in chloride deficient media was not due to increased efflux or alterations in metabolism. The significance of these results for models of transport, methods in transport studies and for other factors are discussed.
    Type of Medium: Electronic Resource
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