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  • 1
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    New York, NY : Springer
    Keywords: Life sciences ; Biochemistry ; Biology / Data processing ; Life sciences ; Protein Science ; Computer Appl. in Life Sciences ; Springer eBooks
    Description / Table of Contents: De Novo Peptide Structure Prediction: An Overview -- Molecular Modeling of Peptides -- Improved Methods for Classification, Prediction, and Design of Antimicrobial Peptides -- Building MHC Class II Epitope Predictor Using Machine Learning Approaches -- Dynamics (UHBD) Program -- Computational Prediction of Short Linear Motifs from Protein Sequences -- Peptide Toxicity Prediction -- Synthetica Structural Routes For The Rational Conversion of Peptides Into Small Molecules -- In Silico Design Of Antimicrobial Peptides -- Information-Driven Modelling Of Protein-Peptide Complexes €œÍnformation-Driven Peptide Dockinǵ€ -- Computational Approaches To Developing Short Cyclic Peptide Modulators Of Protein-Protein Interactions -- A Use of Homology Modeling And Molecular Docking Methods: To Explore Binding Mechanisms of Nonylphenol And Bisphenol a with Antioxidant Enzymes -- Computational Peptide Vaccinology -- Computational Modeling Of Peptide-Aptamer Binding
    Abstract: In this volume expert researchers detail in silico methods widely used to study peptides. These include methods and techniques covering the database, molecular docking, dynamics simulation, data mining, de novo design and structure modeling of peptides and protein fragments. Chapters focus on integration and application of technologies to analyze, model, identify, predict, and design a wide variety of bioactive peptides, peptide analogues and peptide drugs, as well as peptide-based biomaterials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. ℗ Authoritative and practical, Computational Peptidology seeks to aid scientists in the further study into this newly rising subfield
    Pages: XI, 338 p. 69 illus., 43 illus. in color. : online resource.
    ISBN: 9781493922857
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  • 2
    Call number: W26.5:118(2) ; C060:183
    Keywords: Medical statistics ; Medicine / Research ; Diagnostic Techniques and Procedures ; Data Interpretation, Statistical
    Abstract: "Praise for the First Edition " . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students."--Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample sSample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effectsThree case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS(r), and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics"--Provided by publisher
    Pages: xxx, 545 p. : ill.
    Edition: 2nd ed.
    ISBN: 9780470183144
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    W26.5:118(2) available
    C060:183 departmental collection or stack – please contact the library
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  • 3
    Keywords: Life sciences ; Human Genetics ; Health Informatics ; Bioinformatics ; Biostatistics ; Life sciences ; Bioinformatics ; Human Genetics ; Biostatistics ; Health Informatics ; Springer eBooks
    Description / Table of Contents: Drug Discovery -- Translational Bioinformatics and Drug Discovery -- Translational Research in Drug Discovery and Development -- Exploring the Potential of Herbal Ligands towards Multidrug Resistant Bacterial Pathogens by Computational Drug Discovery -- The Progress of New Targets of Anti-HIV and Its Inhibitors -- Exploration of Drug Candidates Interacting on Amyloid-β Protofibrils for Alzheimer’s Disease -- Homology Modeling, Structure Based Pharmacophore Modeling, High Throughput Virtual Screening and Docking Studies of L-Type Calcium Channel for Cadmium Toxicity -- Natural Compounds Are Smart Player in Context to Anticancer Potential: An In Silico and In Vitro Advancement -- Genome Wide Association Studies -- A Survey of Bioinformatics Based Tools in RNA-Sequencing (RNA-Seq) Data Analysis -- Epigenetics and Its Role in Human Cancer -- Methods for Microbiome Analysis -- Pharmacogenomics: Clinical Perspective, Strategies and Challenges -- Computational Network Approaches and Their Applications for Complex Diseases -- Bioinformatics Applications in Clinical Microbiology -- Artificial Intelligence and Automatic Image Interpretation in Modern Medicine -- Computation in Medicine: Medical Image Analysis and Visualization
    Abstract: This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy makers, as well as graduate students majoring in biology, biostatistics, and bioinformatics
    Pages: VIII, 437 p. 85 illus., 59 illus. in color. : online resource.
    ISBN: 9789402410457
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  • 4
    Keywords: Medicine ; Toxicology ; Pharmaceutical technology ; Biochemistry ; Biomedicine ; Pharmaceutical Sciences/Technology ; Pharmacology/Toxicology ; Biochemistry, general ; Springer eBooks
    Pages: : digital
    ISBN: 9783642167478
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  • 5
    Keywords: Life sciences ; Proteins ; Life sciences ; Protein Science ; Springer eBooks
    Description / Table of Contents: Where the Name “GOR” Originates: A Story -- The GOR Method of Protein Secondary Structure Prediction and Its Application as a Protein Aggregation Prediction Tool -- Consensus Prediction of Charged Single Alpha-Helices with CSAHserver -- Predicting Protein Secondary Structure Using Consensus Data Mining (CDM) Based on Empirical Statistics and Evolutionary Information -- Accurate Prediction of One-Dimensional Protein Structure Features Using SPINE-X -- SPIDER2: A Package to Predict Secondary Structure, Accessible Surface Area, and Main-Chain Torsional Angles by Deep Neural Networks -- Backbone Dihedral Angle Prediction -- One-Dimensional Structural Properties of Proteins in the Coarse-Grained CABS Model -- Assessing Predicted Contacts for Building Protein Three-Dimensional Models -- Fast and Accurate Accessible Surface Area Prediction Without a Sequence Profile -- How to Predict Disorder in a Protein of Interest -- Intrinsic Disorder and Semi-Disorder Prediction by SPINE-D -- Predicting Real-Valued Protein Residue Fluctuation Using FlexPred -- Prediction of Disordered RNA, DNA, and Protein Binding Regions Using DisoRDPbind -- Sequence-Based Prediction of RNA-Binding Residues in Proteins -- Computational Approaches for Predicting Binding Partners, Interface Residues, and Binding Affinity of Protein-Protein Complexes -- In Silico Prediction of Linear B-Cell Epitopes on Proteins -- Prediction of Protein Phosphorylation Sites by Integrating Secondary Structure Information and Other One-Dimensional Structural Properties -- Predicting Post-Translational Modifications from Local Sequence Fragments Using Machine Learning Algorithms: Overview and Best Practices -- CX, DPX, and PCW: Web Servers for the Visualization of Interior and Protruding Regions of Protein Structures in 3D and 1D
    Abstract: This thorough volume explores predicting one-dimensional functional properties, functional sites in particular, from protein sequences, an area which is getting more and more attention. Beginning with secondary structure prediction based on sequence only, the book continues by exploring secondary structure prediction based on evolution information, prediction of solvent accessible surface areas and backbone torsion angles, model building, global structural properties, functional properties, as well as visualizing interior and protruding regions in proteins. Written for the highly successful Methods in Molecular Biology series, the chapters include the kind of detail and implementation advice to ensure success in the laboratory. Practical and authoritative, Prediction of Protein Secondary Structure serves as a vital guide to numerous state-of-the-art techniques that are useful for computational and experimental biologists
    Pages: XI, 313 p. 67 illus., 56 illus. in color. : online resource.
    ISBN: 9781493964062
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  • 6
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    Amsterdam : Elsevier Academic Press
    Call number: 08-Phys ; 08-Phys
    Keywords: Magnetic Resonance Imaging / methods ; Mathematics
    Pages: xxii, 1017 p. : ill.
    ISBN: 0120928612
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  • 7
    Call number: W26.5:88
    Keywords: Survival analysis (Biometry) ; Immunity / atlases ; Survival Analysis ; Survivors ; Time Factors
    Pages: xvi, 278 p. : ill.
    ISBN: 0471962015
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  • 8
    Call number: C015:1
    Keywords: Materia medica, Vegetable ; Pharmaceutical chemistry
    Description / Table of Contents: Machine generated contents note: Foreword -- Acknowledgements -- Introduction -- How to Use This Book -- Abbreviations and Symbols --PART I: CHEMICAL COMPOUNDS -- Chemical Compounds in Traditional Chinese Medicines -- References for Part I --PART II:TRADITIONAL CHINESE MEDICINES -- Natural Sources, Effects and Indications of Traditional Chinese Medicines -- Other Natural Sources with Biologically Active Components -- References for Part II --PART III: INDEXES -- Latin Name Index -- English Name Index -- TCM Effects Index -- TCM Indications Index -- Chemical Bioactivity Index -- Molecular Formula Index
    Notes: First ed., published in 1999 entered under X. Yan.
    Pages: xxvii, 1395 p. : ill.
    Edition: 2nd ed.
    ISBN: 0566084279
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  • 9
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    New York, NY : Springer New York
    Keywords: Life sciences ; Biochemistry ; Life sciences ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Introduction to Telomeres and Telomerase -- Analysis of Average Telomere Length in Human Telomeric Protein Knockout Cells Generated by CRISPR/Cas9 -- Telomere Length Analysis by Quantitative Fluorescent In Situ Hybridization (Q-FISH) -- Telomere Strand-Specific Length Analysis by Fluorescent In Situ Hybridization (Q-CO-FISH) -- Telomere G-Rich Overhang Length Measurement: DSN Method -- Telomere G-Overhang Length Measurement Method 2: G-Tail Telomere HPA -- Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In -- Analysis of Yeast Telomerase by Primer Extension Assays -- Assessing Telomerase Activities in Mammalian Cells Using the Quantitative PCR-Based Telomeric Repeat Amplification Protocol (qTRAP) -- Telomeres and NextGen CO-FISH: Directional Genomic Hybridization (Telo-dGH™) -- Visualization of Human Telomerase Localization by Fluorescence Microscopy Techniques -- Cytogenetic Analysis of Telomere Dysfunction -- Probing the Telomere Damage Response -- Induction of Site-Specific Oxidative Damage at Telomeres by Killerred-Fused Shelretin Proteins -- Using Protein-Fragment Complementation Assays (PCA) and Peptide Arrays to Study Telomeric Protein–Protein Interactions -- In Vitro Preparation and Crystallization of Vertebrate Telomerase Subunits -- Human Telomeric G-Quadruplex Structures and G-Quadruplex-Interactive Compounds -- Analysis of Telomere-Homologous DNA with Different Conformations Using 2D Agarose Electrophoresis and In-Gel Hybridization -- Analysis of Telomere Proteins by Chromatin Immunoprecipitation (ChIP)
    Abstract: This third edition volume expands on the previous editions with new and improved assays that ask essential questions of telomere regulation in diverse model systems. The chapters in this book discuss genetic, proteomic, genomic, biochemical, and molecular approaches that provide insight into the complex protein interaction networks active in the telomere chromatin. This book also details information regarding telomere dynamics in response to stress or stimuli. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Telomeres and Telomerase: Methods and Protocols, Third Edition is a valuable and informative resource for anyone who is interested in the developing field of telomeres and telomerase
    Pages: XI, 218 p. 37 illus., 18 illus. in color. : online resource.
    Edition: 3rd ed. 2017.
    ISBN: 9781493968923
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  • 10
    Keywords: Medicine ; Neurosciences ; Neuroradiology ; Animal anatomy ; Neurobiology ; Biomedicine ; Neurosciences ; Animal Anatomy / Morphology / Histology ; Neurobiology ; Neuroradiology ; Springer eBooks
    Description / Table of Contents: Preface -- Acknowledgements -- Author Information -- Background and Methods -- Coronal sections of the tree shrew brain -- Horizontal sections of the tree shrew brain -- Sagittal sections of the tree shrew brain
    Abstract: This atlas is currently the most systematic and comprehensive atlas of the tree shrew brain. The purpose of this book is to help scientists acquire accurate coordinates of the brain regions of the tree shrew, which is becoming a popular animal model for a variety of human diseases. This atlas contains series of 192 coronal sections, 36 sagittal sections, and 49 horizontal sections using Nissl staining or acetylcholinesterase histochemistry as well as a series of diagrams in stereotaxic coordinates. Original photomicrographs are obtained at single-cell resolution. In addition, we also referred to magnetic resonance images acquired at 250 um intervals with a magnetic resonance scanner 9.4T. Many brain structures are first identified in tree shrews and accurately presented in a stereotaxic coordinate system. The Bregma coordinates system is used for the first time in this tree shrew brain atlas. The atlas represents the collaboration between two indispensable skills of brain research, neuroanatomy and stereotaxic surgery. It will be extensively used in neuroscience research, particularly tree shrew brain study, and will help graduate students and researchers understand brain anatomy and acquire accurate reference coordinates
    Pages: XIII, 588 p. 557 illus., 280 illus. in color. : online resource.
    ISBN: 9789811006111
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