Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1076
    Keywords: Trisomy G-21 ; Phosphofructokinase ; Deficiency in Erythrocytes ; Gene Locus ; Glycerophosphatedehydrogenase ; Erythrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den Erythrocyten eines Falles von Trisomie G-21 konnte im Gegensatz zu bisher vorliegenden Berichten eine Verminderung der Aktivität von Phosphofructokinase (PFK) gefunden werden. Daneben wurde eine hohe Aktivität der Glycerophosphatdehydrogenase und in geringerem Ausmaß auch anderer Enzyme nachgewiesen. Die mit dem PFK-Mangel in Zusammenhang stehenden Stoffwechselstörungen sowie die Frage der genetischen Lokalisation dieses Enzyms werden diskutiert.
    Notes: Abstract A deficiency of erythrocyte-phosphofructokinase has been demonstrated in a case of Trisomy-G-21. This is in contrast to findings of other authors who reported an increase of erythrocyte-PFK in cases of Down's syndrome. The metabolic changes caused by PFK deficiency and the problem of genetic localization of this enzyme are discussed. In addition an increased activity of glycerophosphate-dehydrogenase and, to a lesser degree, some other enzyme was found in the patients red blood cells.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Prodynorphin, the precursor of the dynorphin opioid peptides, has been shown to play an important role in several aspects of human diseases and complex traits, e.g., drug abuse, epilepsy, and mood disorders. The objective of this study was to identify polymorphisms in the 5′ control region of the human prodynorphin gene and to relate these polymorphisms to prodynorphin gene expression. Within the core promoter region, a 68-bp sequence was found to occur as a polymorphic element, either singular or as tandemly repeated element two, three, or four times. This 68-bp repeat element contains an AP-1 transcription factor binding site as demonstrated by electrophoretic mobility shift assay. Reporter gene assays were performed and provided evidence for allele dependent different promoter activity. Dynorphin was found to be involved in many pathophysiological processes so that the described prodynorphin alleles may correlate with the occurrence of several diseases, for example, drug addiction. However, prodynorphin allelic distributions were not significantly different in heroin addicts and control subjects.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The concentration of free calcium ions in the cytosol has been shown to influence many components of growth cone behaviour, including the extension of filopodia and veils, the addition of new membrane to the plasmalemma, the retraction and disappearance of filopodia, and gross collapse and retraction of the growth cone. A spatially localized modulation of these processes by very local calcium changes has been proposed to underlie the steering of growth cones by gradients of neurotransmitters, voltage and cell adhesion molecules. Such local control can be studied in mouse neuroblastoma cells, where depolarization causes calcium to rise in a limited number of spatially restricted hotspots, triggering a localized advance. We have studied the simple, club-shaped growth cones that are characteristically found on advancing neurites. Depolarization caused calcium to increase most at the distal, leading tip. Agents that disrupt calcium-induced calcium release do not affect growth cone calcium dynamics, ruling out a local release of calcium at the tip as a cause of the gradient. Using cell-attached patch recording, we find that L-type calcium channels are present at a higher density at the distal tip than in the proximal growth cone. Our results show that the calcium gradients seen in depolarized growth cones are a direct consequence of a gradient of calcium channel density.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Intelligenzentwicklung – Altern – Informationsverarbeitungsgeschwindigkeit –“Latent Growth Curve Models” ; Key words Cognitive development – elderly – mental speed – latent growth curve model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary According to the “speed”-hypothesis of cognitive development, the slowing of information processing in old age is at the core of negative age differences in psychometric intelligence. The present study investigates the “speed”-hypothesis for fluid intelligence at the individual level using Latent Growth Curve Methodology. Date on 4 measurement points come from the Bonn Longitudinal Study of aging (N=128, mean age 67.2, 53% women). Based on principal factor analysis, markers of mental speed were the WAIS Digit Symbol Test and simple psychomotor task. As indicators of fluid intelligence the WAIS Object Assembly and Block Design were used. After separately fitting Latent Growth Curve Models for the trajectory of mental speed and fluid intelligence, a combined model showed no statistically significant improvement of fit for freeing the covariance between the two slope-factors. Interpreting this result, contrary to the “speed”-hypothesis the intraindividual change of fluid intelligence does not relate to the according change of mental speed.
    Notes: Zusammenfassung Die “Speed”-Hypothese der Intelligenzentwicklung postuliert, daß die im Alter zurückgehende Geschwindigkeit der Informationsverarbeitung die zentrale kritische Ressource für psychometrische Intelligenz darstellt. Die vorliegende Arbeit unternimmt den Versuch, die “Speed”-Hypothese unter Verwendung von “Latent Growth Curve Models” auf ihre individuelle Gültigkeit für die Entwicklung der fluiden Intelligenz hin zu überprüfen. Dazu wird auf 4 Meßzeitpunkte des Datenmaterials der Bonner Längsschnittstudie zurückgegriffen (N=128, mittleres Alter 67,2 Jahre, 53% Frauen). Basierend auf einer Hauptfaktorenanalyse werden der HAWIE-Zahlen-Symbol-Test sowie die Leistungen bei einer einfachen psychomotorischen Geschwindigkeitsaufgabe als Indikatoren für Informationsverarbeitungsgeschwindigkeit und die HAWIE-Subtests Figurenlegen und Mosaiktest als Indikatoren für fluide Intelligenz herangezogen. Nach dem getrennten Anpassen zweier “Latent Growth Curve Models” für “speed” und fluide Intelligenz kann in einem kombinierten Modell die Übereinstimmung mit dem Datenmaterial durch eine freie Schätzung der Kovarianz zwischen den beiden “Slope”-Faktoren nicht verbessert werden. Dieses Ergebnis spricht gegen die “Speed”-Hypothese, da die intraindividuellen Veränderungen von fluider Intelligenz nicht mit den entsprechenden Veränderungen der Informationsverarbeitungsgeschwindigkeit zusammenhängen.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 0044-281X
    Keywords: Schlüsselwörter Rehabilitationsforschung – geriatrische Rehabilitation – Rehabilitationserfolg – psychosoziale Aspekte ; Key words Rehabilitation research – geriatric rehabilitation – rehabilitation success – psychosocial aspects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This study considers findings of psychological gerontology as particularly important for geriatric rehabilitation research. Its concrete aim was to describe the course and outcome of geriatric rehabilitation based on a wide range of success criteria, to explore the influencing role of age, sex, and diagnosis as well as to describe the variability pattern of success. The data were gathered from a sample of 100 older adults who underwent treatment in a German inpatient rehabilitation unit. Participants were assessed across five measurement occasions by use of a state-of-the-art geriatric assessment and psychological data collection part. The results underline, for one, that significant improvements of functional as well as psychological capacity were obtained. Second, age and sex played practically no role concerning the course of the success criteria, whereas diagnosis revealed some statistically meaningful effects. Third, it was found that the variability of success was characterized by a relatively homogenous pattern of gain with regard to functional criteria; with respect to psychological variables, heterogeneity was more pronounced and some participants show loss as well, a chance for further improvement of the geriatric rehabilitation.
    Notes: Zusammenfassung Diese Arbeit geht von der Notwendigkeit aus, grundlegende Erkenntnisse der psychologischen und sozialwissenschaftlichen Gerontologie stärker als bisher in die empirische Rehabilitationsforschung mit alten Menschen einzubeziehen. Konkretes Ziel war es, den kurz- und langfristigen Verlauf geriatrischer Rehabilitation mit Hilfe eines erweiterten Spektrums von Erfolgsmaßen zu beschreiben, den Einfluß der Variablen Alter, Geschlecht und Diagnose auf den Verlauf zu prüfen, sowie die interindividuelle Variabilität des Erfolges zu beschreiben. Dazu wurden 100 Patienten der stationären geriatrischen Rehabilitation über 5 Meßzeitpunkte hinweg einer eingehenden medizinisch-geriatrischen sowie psychologischen Erhebung unterzogen. Die Ergebnisse zeigen, daß die Rehabilitation sowohl kurz- als auch langfristig gute bis sehr gute Erfolge in geriatrisch-medizinischen und psychosozialen Aspekten der Lebensqualität erbringt. Das Lebensalter und das Geschlecht spielen nahezu keine Rolle im Hinblick auf den Verlauf der Erfolgsmaße, während sich deutliche Diagnoseeffekte nachweisen lassen. Hinsichtlich der Variabilität des Erfolges zeigen sich vergleichsweise homogene Verläufe in bezug auf die medizinisch-geriatrischen Erfolgsmaße mit deutlichen Erfolgen bei nahezu allen Teilnehmern. In bezug auf die psychosozialen Maße sind neben moderater ausfallenden Gewinne bei einigen Personen auch Verluste zu konstatieren, ein Hinweis, die Bemühungen in diesem Bereich zu verstärken.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The dystonias are a common clinically and genetically heterogeneous group of movement disorders. More than ten loci for inherited forms of dystonia have been mapped, but only three mutated genes have been identified so far. These are DYT1, encoding torsin A and mutant in the early-onset generalized ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Parabolic compound refractive lenses are high quality optical components for hard x rays. They are particularly suited for full field imaging, with applications in microscopy and x-ray lithography. Taking advantage of the large penetration depth of hard x rays, the interior of opaque samples can be imaged with submicrometer resolution. To obtain the three-dimensional structure of a sample, microscopy is combined with tomographic techniques. In a first hard x-ray lithography experiment, parabolic compound refractive lenses have been used to project the reduced image of a lithography mask onto a resist. Future developments are discussed. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The actions of exogenous and endogenous opioids are mediated by at least three different opioid receptors, called μ, κ, and δ. Recently, we have detected a new variant of the rat μ-opioid receptor, which we termed rMOR1B and which differs from rMOR1 (now also called rMOR1A) in the amino acid sequence at the C-terminus. Both isoforms were proposed to be splicing variants of the same gene. To elucidate the molecular mechanism leading to the formation of the new variant, the exon/intron structure of the rat μ-opioid receptor gene in the respective area has been determined by analyzing a genomic P1 phage clone. In addition, we have investigated the putative promoter region of this gene. The present study revealed that rMOR1B is generated by an alternative splicing event whereby a previously unknown exon will be placed behind exon 3 to form rMOR1B mRNA, which is separated from the latter by an intron. Therefore, this new exon has to be called exon 4, whereas the former exon 4, which encodes the C-terminus of MOR1A, now becomes exon 5. Examination of the putative rat promoter region revealed a high degree of nucleotide sequence homology to the mouse gene. Using an RNase protection approach, one single transcription initiation site could be located at 230 bp upstream of the translation start. This is similar to the situation in the mouse, where four major transcription start sites were reported to lie close together around 270 bp upstream of the protein coding region.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 54 (1994), S. 347-348 
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...