Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Vicine (1) and convicine (2) (Vicia faba), causative of the human disease favism, have been conveniently prepared in good yields by a three-step synthesis starting from ethyl glyoxylate. The key step is the reaction of a suitable tetra-O-acetylglucopyranoside with a large excess of guanidine with causes simultaneously deacetylation and coupling.
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