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  • 1
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Wound healing is accompanied by the appearance of myofibroblasts (myoFB) in the wound. In skin wound healing these cells can be derived from dermal fibroblasts (dFB) by the action of TGF-β, released from platelets and inflammatory cells entering the wound in the first phase of wound healing. MyoFB show an increased expression of components of the extracellular matrix such as collagen type I and III. In partial thickness wounds the myoFB disappear after the wound is closed probably by apoptosis. In full thickness wounds however the myoFB remain present and the healing of these wounds is accompanied by the formation of hypertrophic scars. Processes such as excessive collagen depositions, altered collagen remodeling and contraction play a key role in hypertrophic scar formation. We hypothesise that the presence of a specific myoFB subtype, which is less susceptible for apoptotic triggers, is responsible for sustained duration of these processes. In full-thickness wounds the fibroblasts (FB) that populate the wound area are not only recruited from the surrounding dermis but also from other tissues such as the subcutaneous fat. To test the possible involvement of subcutaneous fat fibroblasts (fFB) in scar formation we studied the expression levels of proteins which are thought to play a role in hypertrophic scar formation in these cells. The expression levels of these proteins were compared with the expression levels in dFB and scar derived fibroblasts (sFB). Cultured fFB do show increased expression of α-SMA, collagen types I and III, and TIMPs and decreased expression of MMPs in comparison with cultured dFB. Furthermore the cells show a collagen cross-linking profile comparable with bone collagen resulting in collagen fibers which are less accessible for proteases. This kind of cross-linking is also seen in hypertrophic scars. Taken together the differences in expression profile will lead to excessive collagen deposition. The expression pattern of fFB resembles that of sFB. This suggests that indeed the myoFB from the subcutaneous fat may play a role in hypertrophic scar formation.
    Type of Medium: Electronic Resource
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  • 2
    German Medical Science GMS Publishing House; Düsseldorf
    In:  37. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2019); 20190109-20190112; Schladming, Österreich; DOC16 /20190108/
    Publication Date: 2019-01-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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