CUTANEOUS HUMAN PAPILLOMAVIRUSES
Organ transplant recipients (OTR) have an increased risk of developing keratinocyte carcinomas (KC). The aim of this study was to correlate infection with human papillomaviruses (HPV) belonging to the beta genus (Beta-PV) at transplantation with later development of KC. In a cohort study, sera collected between one year before and one year after transplantation of OTR transplanted between 1990 and 2006 were tested for antibody responses against the L1 capsid antigen of Beta-PV and other HPV genera (Gamma-, Mu-, Nu-, Alpha-PV) using multiplex serology. The OTR were followed for a maximum of 22 years. Cox regression models with KC, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) as outcome variables were used. Sixty out of 445 OTR had developed KC: 14 developed only SCC, 24 only BCC and 22 both types of KC. The time-dependent hazard ratio to develop either or both types of KC, adjusted for age, sex and transplanted organ, in OTR tested Beta-PV seropositive around time of transplantation compared to Beta-PV seronegative OTR was 2.9 (95%CI 1.3-6.4). The hazard ratio for SCC was 2.9 (95%CI 0.99-8.5) and for BCC 3.1 (95%CI 1.2-8.0). There was also an association between Mu-PV seropositivity and KC, but there were no significant associations between other HPV genera tested and KC. A positive seroresponse for Beta-PV around transplantation significantly predicted the development of KC in OTR up to 22 years later, providing additional evidence that infection with Beta-PV plays a role in KC carcinogenesis.Journal of Investigative Dermatology accepted article preview online, 27 October 2014. doi:10.1038/jid.2014.456.
Type of Publication:
Journal article published