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  • Articles  (497)
  • Articles: DFG German National Licenses  (497)
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  • Articles  (497)
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  • 1
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0890-8508
    Keywords: Molluscum contagiosum virus ; biotinylated DNA probe ; in situ hybridization
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1106
    Keywords: Key words Parkinson’s disease ; Postural set ; Stance ; Background activity ; EMG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Abnormal automatic postural responses are thought to contribute to balance impairment in Parkinson’s disease. However, because postural responses are modifiable by stance, we have speculated that some postural abnormalities in patients with Parkinson’s disease are secondary to their stooped stance. We have studied this assumption by assessing automatic postural responses in 30 healthy subjects who were instructed either to stand upright or to assume a typical parkinsonian posture. During both conditions, subjects received 20 serial 4°’toe-up’ rotational perturbations from a supporting forceplate. We recorded short-latency (SL) and medium-latency (ML) responses from stretched gastrocnemius muscles and long-latency (LL) responses from shortened tibialis anterior muscles. We also assessed changes in the center of foot pressure (CFP) and the center of gravity (COG). The results were qualitatively compared to a previously described group of patients with Parkinson’s disease who, under these circumstances, typically have large ML responses, small LL responses and insufficient voluntary postural corrections, accompanied by a slow rate of backward CFP displacement and an increased posterior COG displacement. The stooped posture resulted in unloading of medial gastrocnemius muscles and loading of tibialis anterior muscles. Onset latencies of stretch responses in gastrocnemius muscles were delayed in stooped subjects, but the onset of LL responses was markedly reduced. Amplitudes of both ML and LL responses were reduced in stooped subjects. Prestimulus COG and, to a lesser extent, CFP were shifted forwards in stooped subjects. Posterior COG displacement and the rate of backward CFP displacement were diminished in stooped subjects. Voluntary postural corrections were unchanged while standing stooped. These results indicate that some postural abnormalities of patients with Parkinson’s disease (most notably the reduced LL responses) can be reproduced in healthy subjects mimicking a stooped parkinsonian posture. Other postural abnormalities (most notably the increased ML responses and insufficient voluntary responses) did not appear in stooped controls and may contribute to balance impairment in Parkinson’s disease.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Hereditary sensory neuropathy type I (HSN-I) is an autosomal dominant peripheral neuropathy affecting sensory and motor neurons. The disease involves distal sensory loss, distal muscle wasting and weakness, and variable neural deafness. The HSN1 locus has been mapped to a genetic interval of 3-4 cM on chromosome 9q22.1-q22.3 and is flanked by markers D9S1781 and FB19B7. This interval contains the gene NFIL3, a transcription factor that is regulated by the cytokine IL-3. Northern blot analysis of NFIL3 showed a ubiquitously expressed 2.2-kb mRNA. Expression was highest in the lung, with lower levels of expression in the brain and spinal cord. Mutation analysis by direct sequencing of reverse transcription/polymerase chain reaction products from HSN-I patients excluded the coding region of the NFIL3 from being involved in the pathogenesis of HSN-I.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2307
    Keywords: Key words Kidney ; Solitary cyst ; Transitional cell carcinoma ; Fine-needle aspiration biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The differentiation between benign and malignant cystic lesions of the kidney is a diagnostic challenge. Medical imaging aids in this task, but many cystic renal lesions require further work-up, frequently by computed tomography-guided fine needle aspiration. We report on the pathological findings in a case of moderately differentiated papillary transitional carcinoma, which arose in a pre-existing pyelocaliceal cyst in a 53-year-old man. In the case of this lesion, the distinction between a benign and a malignant renal cyst is blurred. To our knowledge, this is the third such occurrence to be reported and the first to be diagnosed by fine needle aspiration biopsy.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven fragments of the spike (S) gene cDNA of transmissible gastroenteritis virus (TGEV), as well as the full length cDNA, were cloned and expressed in baculovirus vectors. Piglets were immunized with cells infected with the recombinant viruses. Each of the recombinants induced TGEV-specific antibodies detected in a fixed cell enzyme immunoassay. The amino terminal half of the S protein, containing all four major antigenic sites (A, B, C and D), and encoded by a 2.2 kb fragment of the S gene, induced virus neutralizing (VN) antibody titers comparable with those induced by the complete S protein. Recombinant proteins lacking the A antigenic site, or with a deletion including the putative receptor binding sites and the D antigenic site, were not capable of inducing levels of VN antibodies similar to those induced by the whole S protein.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 10 (1986), S. 269-280 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'irradiation est employée couramment pour traiter d'emblée ou secondairement les tumeurs pelviennes. Bien que les complications aiguËs intéressant les régions irradiées aient été éliminées grâce à l'amélioration technique de l'irradiation, les complications tardives persistent sous la forme de lésions pelviennes et périnéales complexes. En raison d'une altération de la vascularisation locale secondaire à une endartérite oblitérante, le traitement de ces lésions échoue souvent et se traduit par une infection secondaire ou par une cicatrisation difficile. Vingt-quatre malades présentant des lésions radiques pelviennes ont été traités avec succes par des lambeaux musculaires, musculocutanés ou fascio-cutanés. Leur étude permet d'exposer la base physiologique de la réparation par lambeaux vasculaires. Le choix du lambeau spécifique dépend de la localisation de la lésion: région antérieure du pelvis, région inguinale, périnée, cavité pelvienne et sacrum. Les lambeaux vascularisés doivent posséder un pédicule vasculaire provenant d'une région qui n'a pas été irradiée. Les lambeaux qui conviennent peuvent provenir de la partie antérieure de la paroi abdominale, de la région antérieure ou postérieure de la cuisse, de la région pelvienne postérieure et doivent posseder un arc de rotation permettant de couvrir les zones victimes de l'irradiaion. En conclusion l'exérèse de la région irradiée suivie du recouvrement du défect pariétal par un lambeau bien vascularisé est une méthode réparatrice utile et fiable pour traiter les lésions nécrotiques postradiques du pelvis et du périnée.
    Abstract: Resumen La radioterapia se utiliza en la actualidad como modalidad de manejo primario o adyuvante de tumores pélvicos. Aunque los avances en las técnicas de irradiation han eliminado casi por completo las complicaciones agudas sobre el campo irradiado, todavía se presentan complicaciones tardías en la herida, las cuales resultan en heridas crónicas de alta complejidad en la pelvis y el periné. Puesto que tales heridas son un reflejo de alteraciones circulatorias locales secundarias a endarteritis obliterativa, su manejo local con frecuencia falla en lo que se refiere al control de la infección secundaria o al logro de la cicatrización espontánea. Veinticuatro pacientes con heridas perineales crónicas han sido sometidos recientemente a exitosa reparación mediante el uso de mÚsculo y de colgajos musculocutáneos y fasciocutáneos. La revisión de estos pacientes demuestra las bases fisiológicas para el uso de colgajos vascularizados en el cierre de estas heridas. La selección de colgajos específicos se fundamenta en la localización de la herida pélvica de irradiación sobre la pelvis anterior y la región inguinal, el periné y la cavidad pélvica, y el sacro. Colgajos bien vascularizados deben poseer una fuente independiente de circulación ubicada lejos del lugar de la lesión por irradiación, si se quiere lograr una buena cobertura de la herida. Se puede disponer de colgajos musculares y fasciocutáneos alimentados por pedículos confiables ubicados sobre las regiones anteriores y posteriores del muslo y sobre la región pélvica posterior, con un arco adecuado de rotación para cubrir la mayorá de los defectos pélvicos. Los colgajos más frecuentemente utilizados en nuestro estudio incluyeron: mÚsculos rectus femoris, rectus abdominis, gracilis y glÚteos máximos, junto con colgajos mÚsculocutáneos y el colgajo fasciocutáneo gluteal y del muslo. La debridación de la herida y el cubrimiento simultáneo con colgajos bien vascularizados han quedado establecidos como método Útil y confiable para la reparación de heridas complejas de la pelvis resultantes de necrosis por irradiación.
    Notes: Abstract Radiation therapy is currently utilized for primary or adjuvant therapy for pelvic tumors. Although improvements in radiation delivery techniques have largely eliminated acute complications in the radiation field, occurrences of late wound complications persist and result in complex pelvic and perineal wounds. Since these wounds reflect underlying impaired local circulations secondary to obliterative endarteritis, local wound management frequently fails either to control secondary infection or to allow spontaneous wound closure. Twenty-four patients with chronic pelvic wounds have recently undergone successful wound repair with use of muscle, musculocutaneous, and fasciocutaneous flaps. This review of these patients will demonstrate the physiologic basis for vascularized flaps for wound closure. Specific flap selection is based on the location of the pelvic radiation wound in the anterior pelvis and inguinal region, perineum and pelvic cavity, and sacrum. Well-vascularized flaps must have an independent source of circulation distant to the site of radiation damage for reliable wound coverage. Muscle and skin fascial flaps are available based on reliable pedicles located in the anterior abdominal wall, anterior and posterior thigh, and posterior pelvic region with adequate arc of rotation to cover most pelvic defects. Flaps frequently utilized in this study included: rectus femoris, rectus abdominis, gracilis, and gluteus maximus muscle and musculocutaneous flaps, and the gluteal thigh skin fascial flap. Wound debridement and simultaneous coverage with well-vascularized flaps have been established as a useful and reliable method to repair complex wounds of pelvic radiation necrosis.
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