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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  21. Wissenschaftliche Jahrestagung der DGPP; 20040910-20040912; Freiburg/Breisgau; DOC04dgppV38 /20040909/
    Publication Date: 2004-09-09
    Description: The following study measured the processing of different phonemes in dependence on different gap durations between two consonant-vowel items. Event related potentials (ERPs) were recorded to a phoneme change occurring during the iterative presentation of /da-da/, occasionally interrupted by a stimulus /da-ba/. The pre-attentive detection of the change is measured by the difference between the ERPs of the frequently presented standard stimulus and the rarely presented deviant stimulus. The experiment was conducted during the first year of life to describe the maturation. The results showed that the phoneme change including a short gap can only be detected in the later maturational stadium, whereas a long gap is detected already in the age of four weeks. The greater mask effect in younger infants can be seen to be induced by a slower neural processing in early infancy.
    Description: Der kontinuierliche Sprachschall setzt sich aus vielfältigen Variationen akustischer Parameter zusammen. Gemessen an der Vielzahl akustischer Merkmale ist nicht genau klar, woran sich das auditorische System orientiert, um eine Segmentierung und Identifizierung einzelner Wörter zu bewerkstelligen. Die Verarbeitung von akustischen Merkmalen der Sprache kann mit Hilfe von Ereignis Korrelierten Potenzialen (EKP) sichtbar gemacht werden. In der folgenden Studie wurde die Verarbeitung von Phonemkategorien in Abhängigkeit von unterschiedlich langen Silbengrenzen (50ms und 150 ms) im Alter von 4 Wochen, fünf Monaten und 13 Monaten getestet. Um die Detektion einer Phonemänderung zu messen wurde der Reiz /da-da/ iterativ präsentiert. Die so angelegte neuronale Gedächtnisspur soll durch eine Abweichung der Phonemkategorie /da-ba/ unterbrochen werden. Die prä-attentive Detektion zeigt sich erwiesenermaßen in der Differenz der EKP beider Reize (Näätänen, R. 1992).Die Ergebnisse zeigen, dass eine kurze Silbengrenze erst im Alter von 13 Monaten identifiziert wird. Die langsame Verarbeitung der ersten Silbe scheint hier die Verarbeitung der zweiten Silbe zu überlagern. Eine lange Silbengrenze vereinfacht die Verarbeitung und kann schon im Alter von 4 Wochen genutzt werden, um Silben zu segmentieren. Darüberhinaus zeigen die morphologischen Veränderungen anhand von Amplitude und Latenz eine deutliche Entwicklung des auditorischen Systems innerhalb des ersten Lebensjahres.
    Keywords: ddc: 610
    Language: English
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  21. Wissenschaftliche Jahrestagung der DGPP; 20040910-20040912; Freiburg/Breisgau; DOC04dgppV15 /20040909/
    Publication Date: 2004-09-09
    Description: Hintergrund und Fragestellung: Megalin ist ein zur LDL-Rezeptorgruppe gehörendes Membranrezeptorprotein. Über den Megalinrezeptor erfolgt u.a. der Hauptteil der Endozytose von Aminoglykosidantibiotika in der Niere adulter Säugetiere. Außerdem zeigen Untersuchungen am Innenohr der Ratte, dass der Megalinrezeptor auch dort und zwar an den Marginalzellen der Stria vascularis, an der apikalen Oberfläche und an den Epithelzellen der Reissner-Membran exprimiert wird. Zur Vorbereitung von Versuchen zur Bedeutung des Megalinrezeptors am Innenohr der Maus sollte zunächst die Expression von Megalin im Innenohr von NMRI-Mäusen untersucht werden. Tiere und Methode: Zur Verwendung kamen Kryoschnitte von NMRI-Mäusen des 18. postnatalen Tages. Diese wurden mit dem Megalin-Antikörper als Primärantikörper und anschließend mit einem Sekundärantikörper zur fluoreszenzmikroskopischen Darstellung inkubiert.Ergebnisse: Sowohl in den Marginalzellen der Stria vascularis als auch im Bereich der Epithelzellen der Reissner-Membran der pn18 NMRI-Maus wird Megalin exprimiert.Schlussfolgerung: Megalin wird im Innenohr der NMRI-Maus sowohl in der Stria vascularis als auch im Bereich der Resissner-Memran exprimiert. Der Ort dieser Proteinexpression ist funktionell bedeutsam für die Generierung des endocochleären Potentials und die Zusammensetzung der Endolymphe. Ein Einfluss von Megalin auf die Innenohrfunktion im Mausmodell scheint möglich.
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch); 20080601-20080604; Würzburg; DOCDI.06.05 /20080530/
    Publication Date: 2008-05-30
    Keywords: craniopharyngeomas ; stereotactic radiotherapy ; Kraniopharyngeome ; stereotaktische Radiotherapie ; ddc: 610
    Language: English
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA); 20120927-20120929; Aachen; DOCV516 /20120918/
    Publication Date: 2012-09-19
    Keywords: ddc: 610
    Language: English
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  • 5
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    German Medical Science; Düsseldorf, Köln
    In:  56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC); 20050507-20050511; Strasbourg; DOC09.05.-05.06 /20050504/
    Publication Date: 2005-05-05
    Keywords: ddc: 610
    Language: English
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  • 6
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    German Medical Science; Düsseldorf, Köln
    In:  20. Wissenschaftliche Jahrestagung der DGPP; 20030912-20030914; Rostock; DOCV13 /20030912/
    Publication Date: 2003-09-12
    Description: The aim of the paper was to present voice and speech disorders associated with motor neuron disease - MND. Two cases of MND were described. Communication problems - dysphonia and dysarthria were one of their early manifestations. It is supposed that sulcus vocalis, which is the result of the degeneration process of the vocal muscle, is the laryngeal presentation of MND.
    Keywords: ddc: 610
    Language: English
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  • 7
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    German Medical Science; Düsseldorf, Köln
    In:  20. Wissenschaftliche Jahrestagung der DGPP; 20030912-20030914; Rostock; DOCP21 /20030912/
    Publication Date: 2003-09-12
    Description: Previous studies demonstrated that grammar school children with developmental reading and spelling disorders (DD) attained significantly lower scores in the dichotic discrimination test by Feldmann (dDF) than age-matched inconspicuous children. Lower scores of dyslectic children were linked to poor left ear dichotic listening performance. Appropriate measures for laterality are laterality indices (left/right ear preferences). At present no studies exist that demonstrate that lateral indices are useful for interpreting dDF perform-ances. One hundred and fifteen right-handed normal hearing children aged 8 to 10 years (I.Q 〉84) took the dichotic listening test by Feldmann. Sixty-one Children (DD group) had reading and spelling disorders (ICD 10; F 81.0), whereas the other 54 were inconspicuous (control group). We used the HUGDAHL formula to calculate the laterality indices. Results demonstrated a significant group difference (p〈0.009): 48 DD children (78.7%) showed right ear preferences. Twenty nine children (53.7%) in the control group demonstrated right ear preferences. Twenty two DD children (36.1%) presented with an extremely high right ear preference. Calculations of the two factorial analysis of variance (age/group) showed a significant main effect for the factor group. Control group measures also indicated that laterality indices tend to level with age (tendentially), whereas no age effect was registered in the DD group. We believe that the HUGDAHL laterality index can be quite helpful in the interpretation of dDF performance.
    Keywords: ddc: 610
    Language: English
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  • 8
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    German Medical Science; Düsseldorf, Köln
    In:  20. Wissenschaftliche Jahrestagung der DGPP; 20030912-20030914; Rostock; DOCV09 /20030912/
    Publication Date: 2003-09-12
    Description: Videokymography (VKG) was introduced into clinical practice in Medical Healthcom Prague in 1996. Since that time it has become an indispensable supplemental diagnostic method to strobovideolaryngoscopy. The total of 3953 examinations have been carried out here using the combination of the two methods. The laryngoscopic images allow evaluation of the vocal folds during respiration and reveal organic pathology. Stroboscopic images allow qualitative evaluation of the vocal fold vibration and the glottal closure and reveal organic and functional disorders in an early stage. VKG supplements these pieces of information by revealing the detailed dynamics of the vocal fold oscillations, which is depicted within a single image. The method enables an objective documentation of the vocal fold vibration in hoarse voices as well as during fast laryngeal events in which stroboscopy fails. It allows discovering subtle functional and early organic changes at specific places of the vocal folds. The combination of the strobovideolaryngoscopy and VKG enables an early diagnostics of functional and organic voice disorders, accurate documentation of the findings and evaluation of the changes as a result of therapy. It can be applied also in studying substitute phonational mechanisms or in examining creation of tone in brass instrument playing. Apart from its clinical value, the method has been helpful in experimental voice research and in development of voice prostheses. The presentation summarizes the authors' experience with VKG and outlines the possibilities of the method in future.
    Keywords: ddc: 610
    Language: English
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  • 9
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  The Structure of Medical Education in Europe: Implementing Bologna - On the way to a European success story?; International Conference hosted by the German Rectors' Conference (HRK); 20081010-20081011; Berlin; DOC08hrk10 /20110113/
    Publication Date: 2011-01-13
    Keywords: ddc: 610
    Language: English
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  • 10
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  25. Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie; 20080912-20080914; Düsseldorf; DOC08dgppV54 /20080827/
    Publication Date: 2008-08-28
    Description: We report on a 55 year old, internationally renowned baritone soloist who's left side of his neck was injured whilst being hit by the edge of his fellow sportsman's hand during a sportive exercise of martial arts (Karate). Ever since he suffered, in addition to severe recurrent pain in his neck, jaw and shoulder, from the inability to use the upper fifth of his formerly usable voice range: Using the other parts of his vocal spectrum took much more effort than ever before. Tones of the upper part of his formerly easily and well differentiated range were no longer stable, some of them even could not be reached at all. Thus he was unable to perform as an active singer on stage, even the ability to teach was seriously limited. The patient's past medical and surgical history was without particularly remarkable events. On thorough examination of his head and neck including videostroboscopy checking lower and higher pitches and lower and higher loudness of phonation there were no pathological morphologic and functional findings; even a larynx rotation whilst attempting to phonate a glissando upwards suggesting a malfunction of a superior laryngeal nerve leading to malfunction of a cricothyroid muscle could not be proven. On palpation of the neck we found a particularly tender region approximately in the middle of the left sternocleidomastoid muscle. The X-Ray pictures of his head, neck and upper chest did not show any bony lesions. As it's only pathological finding, a MRI scan taken 4 days after the accident revealed a hematoma, approximately 1x1x1 centimetres in size, on the medial surface of his left sternocleidomastoid muscle. This hematoma was checked using sonography in a follow up of 6 weeks, it resolved completely, so that it was no longer sonomorphologically detectible. But, despite of complete resorption of the hematoma, the problems of the singer's voice persisted. Hence we presumed a lesion of his head, neck and upper chest muscles and tendons which cannot be detected by radiomorphological methods. After being referred to our manual medicine specialist a specific diagnostic procedure was carried out. A blockade of the muscles of the thoraco-cervical transitional region including tender trigger points of the left sternocleidomastoideal, scalene and digastric muscles were detected and thus treated using soft, so called mobilizing techniques of manual therapy. The muscular dysfunction, the pain of the neck and upper chest could be substantially eased, the singer's voice did not completely return to normal yet but improved significantly. The patient ever since had been able to perform technically less ambitious rolls again, gradually further improving his vocal performance.
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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