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  • 1975-1979  (2)
  • 1976  (2)
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  • 1975-1979  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Computing 17 (1976), S. 23-36 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract This papers gives a survey of possible speed-ups of matrix-multiplication by the methods due to S. Winograd and V. Straßen. Questions of implementation of the algorithms are investigated and formulas for the required additional core-memory are given. By using a machine model which is similar to existing computers the results given are of practical importance.
    Notes: Zusammenfassung Diese Arbeit soll eine Übersicht über den möglichen Zeitgewinn geben, der durch den Einsatz der schnelleren Matrix-Multiplikationen von S. Winograd und V. Straßen erzielbar ist. Implementierungsfragen werden besprochen und der benötigte Zusatzspeicher wird ermittelt. Die Abschätzungen beruhen auf einem Rechner-Modell, welches den heutigen Rechenanlagen nachgebildet ist, und liefern daher realistische Ergebnisse.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1912
    Keywords: p-Nitrophenyl diazonium fluoroborate ; Cholinergic neurons ; Acetylcholine receptor ; Acetylcholinesterase ; Affinity labelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electrophysiological experiments were done to investigate the effect of p-nitrophenyl diazonium fluoroborate (p-NPD) on motor endplates of the frog's m. cutaneus pectoris. The compound has no direct depolarizing effect on the postsynaptic membrane and stabilizes it irreversibly when added to the bath. Longtime iontophoretical applications of p-NPD produce a biphasic effect: initially a potentiation of the depolarizations due to acetylcholine (ACh) (both iontophoretically applied and presynaptically liberated), and subsequently an inhibition of the response to ACh. When the acetylcholinesterase (AChE) is inactivated previously, only the inhibiting effect of the compound is demonstrable. The association constant of p-NPD to purified AChE and to membrane fragments of electroplax was determined by biochemical methods. The compound's affinity to the AChE was found to be about 20 times greater than to the acetylcholine receptor (AChR). Iontophoretical application of p-NPD to cholinergic neurons in the hippocampal cortex of the cat also produced the characteristic biphasic effect on ACh-induced activity of these investigated neurons. The results suggest that the biphasic effect depends on the capacity of p-NPD to combine with both the AChE and the AChR. The AChE is first inhibited with low concentrations thereby potentiating the ACh response. At higher concentrations the AChR's are progressively inhibited too, thereby diminishing the excitability of the postsynaptic membrane up to a complete block.
    Type of Medium: Electronic Resource
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