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  • 1
    ISSN: 1432-1076
    Keywords: Partial trisomy 10p ; Malformation-retardation-syndrome ; Inheritance ; Reciprocal translocation, balanced/unbalanced ; Maternal carrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird von einer Familie berichtet, in der durch mütterliche balancierte Translokation t(5;10)(p15;p13) eine unbalancierte Chromosomenkonstitution bei zwei Kindern entstand. Mit Hilfe der G-Bandenanalyse wurde sie als Trisomie des distalen Abschnitts des kurzen Armes von Chromosom 10 (p13→pter) identifiziert. Der Vergleich mit 15 Literaturberichten von Trisomie 10p bestätigt das Vorliegen eines charakteristischen Dysmorphiesyndroms.
    Notes: Abstract This is the report of a family in which a balanced translocation in the mother t(5;10)(p15;p13) led to an unbalanced chromosomal constitution in two children. It was identified by G-banding analysis as trisomy of the distal portion of the short arm of chromosome 10 (p13→pter). Comparison with 15 previous reports of trisomy 10p confirms the existence of a characteristic dysmorphic syndrome.
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  • 2
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Specific IgE-antibodies and haemagglutinins to bee venom were determined in fifty-five bee sting allergic patients, fifty-seven bee keepers and fifty-two blood donors without evident allergy to hymenoptera stings. IgE-antibodies were detected by RAST in 70% of allergic patients, 40% of bee keepers and 12% of blood donors.Most bee keepers with detectable IgE-antibodies to bee venom recorded severe local or even general reactions to bee stings. Most blood donors with detectable specific IgE had been stung by hymenoptera in the past.High titres of haemagglutinating antibodies against phospholipase A were found in most bee keepers, occasionally in bee sting allergic patients but only rarely in blood donors.The determination of specific IgE-antibodies to insect venoms by RAST seems to be a valuable method for the diagnosis of hymenoptera sting allergy.
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  • 3
    ISSN: 1432-1912
    Keywords: p-Nitrophenyl diazonium fluoroborate ; Cholinergic neurons ; Acetylcholine receptor ; Acetylcholinesterase ; Affinity labelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electrophysiological experiments were done to investigate the effect of p-nitrophenyl diazonium fluoroborate (p-NPD) on motor endplates of the frog's m. cutaneus pectoris. The compound has no direct depolarizing effect on the postsynaptic membrane and stabilizes it irreversibly when added to the bath. Longtime iontophoretical applications of p-NPD produce a biphasic effect: initially a potentiation of the depolarizations due to acetylcholine (ACh) (both iontophoretically applied and presynaptically liberated), and subsequently an inhibition of the response to ACh. When the acetylcholinesterase (AChE) is inactivated previously, only the inhibiting effect of the compound is demonstrable. The association constant of p-NPD to purified AChE and to membrane fragments of electroplax was determined by biochemical methods. The compound's affinity to the AChE was found to be about 20 times greater than to the acetylcholine receptor (AChR). Iontophoretical application of p-NPD to cholinergic neurons in the hippocampal cortex of the cat also produced the characteristic biphasic effect on ACh-induced activity of these investigated neurons. The results suggest that the biphasic effect depends on the capacity of p-NPD to combine with both the AChE and the AChR. The AChE is first inhibited with low concentrations thereby potentiating the ACh response. At higher concentrations the AChR's are progressively inhibited too, thereby diminishing the excitability of the postsynaptic membrane up to a complete block.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Computing 17 (1976), S. 23-36 
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract This papers gives a survey of possible speed-ups of matrix-multiplication by the methods due to S. Winograd and V. Straßen. Questions of implementation of the algorithms are investigated and formulas for the required additional core-memory are given. By using a machine model which is similar to existing computers the results given are of practical importance.
    Notes: Zusammenfassung Diese Arbeit soll eine Übersicht über den möglichen Zeitgewinn geben, der durch den Einsatz der schnelleren Matrix-Multiplikationen von S. Winograd und V. Straßen erzielbar ist. Implementierungsfragen werden besprochen und der benötigte Zusatzspeicher wird ermittelt. Die Abschätzungen beruhen auf einem Rechner-Modell, welches den heutigen Rechenanlagen nachgebildet ist, und liefern daher realistische Ergebnisse.
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  • 5
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Stability in aqueous solution of some complexes of heavy metals with diaza-polyoxamacrocyclic ligandsStability of metal complexes (Mn+ = Cu2+, Ni2+, Co2+, Zn2+, Pb2+, Ag+ and Cd2+) with five diaza-polyoxamacrocycles (L = [2.1.1], [2.2.1], [2.2.2], [2.1] and [2.2] ) have been determined at 25°, in 0.1 M Et4N+ClO4- aqueous solutions, by means of potentiometric titrations. All cations form MLn+ complexes; Cu2+ also forms the MHL(n+1)+ protonated species with both [2.2.1] and [2.1.1] ligands. The stability of these complexes has been discussed in terms of structure and by considering the ionic radii of the cations together with the radii of the macrocyclic cavities. Different behaviour is observed between some of these complexes and the well known alkali and alkaline-earth cryptates, partly due to the more covalent nature of bonds formed by the investigated cations and the donor sites of the ligands. The effect of the substitution of two oxygen by two sulfur atoms in the pentadentate ligand [2.1] on the stability of the complexes is reported.
    Additional Material: 1 Ill.
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