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  • 1
    Unknown
    Stuttgart : Thieme
    Call number: 05-MET-15:21
    Keywords: Magnetic Resonance Spectroscopy
    Pages: xii, 685 p.
    ISBN: 3-13-632801-9
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    05-MET-15:21 departmental collection or stack – please contact the library
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  • 2
    facet.materialart.
    Unknown
    Frankfurt, M. : Umschau-Verl.
    Call number: 0420:36
    Keywords: Elektrophorese / Arbeitsmethodik
    Pages: 36 p.
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    0420:36 departmental collection or stack – please contact the library
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  • 3
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A bronchial P cell carcinoid, which was negative for all hormones immunocytochemically tested, showed a globular intracytoplasmic inclusion in almost every cell. The inclusions were not clearly distinguishable using the haematoxylin-eosinsafran procedure; they were best demonstrated with the Masson trichrome stain and the Grimelius technique and were easily detected in 1 μm thick Epon sections as target-like structures. On electron microscopy, they were found to be composed of filamentous aggregates entrapping a few endosecretory granules, which showed degenerative changes. The filaments, 8–10 nm in diameter, lacked any periodicity; they were randomly dispersed in the central area and arranged in broken concentric swirls at the periphery of the inclusions. The globules lacked the tinctorial properties of amyloid, but showed a strong immunostaining for keratin-like proteins. A systematic investigation of 12 APUDomas of bronchial or duodenopancreatic origin, using both light and electron microscopy, identified a few filamentous bodies in one case, a somatostatin cell tumour of ampulla of Vater. In both cases, the structures appeared similar to those previously reported in growth hormone cell pituitary adenomas as well as in a few bronchial or gut carcinoids. Whatever their nature, morphological data suggest that they are related to abnormalities in the secretory function, involving the Golgi apparatus, the endosecretory granules and the microtubular microfilamentous system.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Aphidicolin, a specific inhibitor of DNA polymerase α, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocytes. Specific chromosome bands, especially 2q31, 3p14, 6q26, 7q32, 16q23, and Xp22 were preferentially damaged in lymphocytes from each of 12 subjects studied. Total and site-specific damage was dose dependent and greatly increased when folic acid was removed from the medium. The sites most sensitive to aphidicolin damage include the “hot spots” seen under conditions of thymidylate stress and in studies of spontaneous chromosomal damage. The fragile X site, which can also be induced by thymidylate stress, was not induced by aphidicolin in lymphocytes, suggesting a separate mechanism for its induction. Aphidicolin represents a novel tool for detection of hot spots on human chromosomes through the mechanism of DNA polymerase α inhibition. The hot spots induced by aphidicolin represent a new class of fragile sites which we term common fragile sites.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Mitochondrial myopathy ; Lactic acidosis ; Respiratory chain ; Succinate cytochrome-c-oxidoreductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A male infant had severe muscular hypotonia from birth. Recurrent vomiting with dehydration and severe metabolic acidosis complicated the course. Elevated lactate (up to 12.3 mmol/l; n〈2), pyruvate (0.4 mmol/l; n〈0.05) and alanine levels were found in serum with an abnormal lactate/pyruvate ratio (〉30; n〈15). In urine the concentrations of lactate, pyruvate, alanine and of several intermediates of the citric acid cycle were increased. In muscle, numerous disseminated “ragged red fibres” were found by light microscopy; muscle fibres were found to contain subsarcolemmal aggregates of mitochondria, lipid droplets and glycogen by electromicroscopical methods. More-over, mitochondria with a typical circular arrangement of cristae were noticed. In liver homogenates normal activities of pyruvate carboxylase and pyruvate dehydrogenase complex were found; in liver mitochondria also succinate-cytochrome-c-oxidoreductase activity was normal. However, in muscle no succinate-cytochrome-c-oxidoreductase activity was detectable. The patient became increasingly lethargic and died because of sepsis at 5 months of age.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 11 (1984), S. 191-196 
    ISSN: 1432-2161
    Keywords: Meniscotibial ligament ; Coronary ligament ; Medial meniscus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preservation of the meniscus whenever possible is essential in maintaining knee stability and preventing premature osteoarthritis. Peripheral meniscal tears are the most amenable to surgical repair. This study evaluates the peripheral attachments of the medial meniscus and focuses on a specific tear limited to the meniscotibial ligament (coronary ligament). The diagnosis is made arthrographically when the medial meniscus floats above the tibial plateau without separating completely from the capsule. The lateral meniscus is rarely involved in this type of injury.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-8491
    Keywords: Dexamethasone suppression test ; Psychiatric disorders ; Intervening variables ; Dexamethason-Suppressions-Test ; Psychiatrische Erkrankungen ; intervenierende Variable
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In den letzten Jahren wurde in zahlreichen Publikationen der Dexamethason-Suppressions-Test (DST) als geeignetes Instrument zur Diagnostik endogener Depressionen dargestellt. Eigene Untersuchungen an 333 psychiatrischen Patienten und 121 gesunden Kontrollpersonen sprechen gegen eine differentialdiagnostische Wertigkeit des DST. Diese Aussage wird durch neuere Befunde anderer Arbeitsgruppen gestützt. Diagnoseunabhängige Variable wie Schweregrad der Erkrankung, Gewichtsverlust, Schlafstörungen, situativer Stress, Medikamenten- und Alkohol-Entzug sowie die Pharmakokinetik von Dexamethason scheinen entscheidend das Testergebnis zu beeinflussen.
    Notes: Summary In the past few years there have been numerous publications, which have stressed the value of the Dexamethasone Suppression Test (DST) as a diagnostic marker of endonous depression. Our own studies in 333 psychiatric inpatients and 121 healthy subjects did not reveal a differential diagnostic use for the DST. This result is in good agreement with recent results published in the literature. Our own data demonstrate, however, that intervening variables, such as severity of illness, weight loss, sleep disturbances, situational stress, drug and alcohol withdrawal and the pharmacokinetics of dexamethasone, have an important influence on the DST results, regardless of the diagnostic classification.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: Hyperinsulinaemia ; insulin resistance ; insulin degradation ; haemochromatosis ; cirrhosis ; insulin ; glucagon ; C-peptide ; gastric inhibitory polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study investigated early alterations of glucose metabolism in idiopathic haemochromatosis. Circulating concentrations of glucose, insulin, C-peptide, glucagon, and gastric inhibitory polypeptide (GIF) were measured after a 100-g oral glucose load in 10 men with idiopathic haemochromatosis in the non-cirrhotic stage of the disease. All had normal glucose tolerance and normal body weight. Ten matched healthy subjects were studied as controls. Insulin concentrations increased to significantly higher levels in patients with idiopathic haemochromatosis than in the control subjects from 30 to 180min after the glucose load (p〈0.01), while fasting insulin concentrations were not significantly different (p〉 0.05). Concentrations of glucose, glucagon, C-peptide, and GIF were not significantly different at any time (p〉 0.05). Thus, patients with idiopathic haemochromatosis show hyperinsulinaemia and hence insulin resistance without impaired glucose tolerance in the non-cirrhotic stage. Since pancreatic insulin secretion (C-peptide), glucagon secretion, and the entero-insulinar axis (GIP) are not impaired in these non-cirrhotic patients with idiopathic haemochromatosis, iron accumulation in the hepatocytes may be responsible for the impaired insulin effect and may cause impaired hepatic insulin extraction.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 27 (1984), S. 1-2 
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using a cytoplasmic actin cDNA probe we have localized a number of actin sequences in the human genome using a novel in situ hybridization technique. Metaphase chromosomes treated to produce R-bands were directly annealed with 125I-labeled actin probe. Under these conditions many regions of the genome were apparently denatured enough to be capable of hybridizing with the probe. Most of the actin sites detected in prior experiments using chromosome preparations, which had been completely denatured, were recognized in this experiment. The major advantage of this method over standard in situ hybridization techniques is the marked increase in the resolution of subregional localization.
    Type of Medium: Electronic Resource
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