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  • 1990-1994  (4)
  • 1960-1964
  • 1991  (4)
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  • 1990-1994  (4)
  • 1960-1964
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  • 1
    ISSN: 1432-1041
    Keywords: Nicotine ; bioavailability ; nasal spray
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absolute bioavailability of nicotine administered nasally, as drops to the nasal conchae and nasal septum, and as a nasal spray, has been studied in eight healthy volunteers. Single nasal doses of 1 mg nicotine were given and plasma concentrations of nicotine were followed for 6 h. Compared to an intravenous infusion of nicotine, the bioavailability of the nasal administrations was 60 to 75%. The rate of absorption was fast, the maximum concentration being reached after about 10 min. In the present study, there was no significant difference in the rate or extent of absorption between the different nasal treatments.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Sixty fasciotomies of the deep posterior compartment were performed on 30 patients with longstanding bilateral medial tibial syndrome (mean duration 25 months). The initial symptoms occurred during sports activities in all cases. Only 2 of the athletes were able to continue sports at an ordinary activity level. The diagnosis was based on a typical history of longstanding exertional pain and clinical findings of tenderness at the postero-medial border of the tibia. Radiographs showed no abnormalities. Scintigrams were performed in 12 patients in whom stress fractures could not be excluded by radiographs and clinical examination. Conservative treatment failed to relieve the symptoms. At follow-up 34 months (range 6–85) after surgery, 95% of the men and 73% of the women were free of symptoms or improved compared with prior to surgery. Whereas 68% of the men were totally free of symptoms, the corresponding figure for the women was 36%. Ninety-five percent of the men and 82% of the women returned to sport after surgery. Seventy-four percent of the men and 54% of the women returned to an activity level similar to that prior to injury. We conclude that fasciotomy of the deep posterior compartment gives a good long-term result in patients with medial tibial syndrome when conservative treatment fails. There was no significant difference between the sexes.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The effect of short-term altitude training on sea-level physiological characteristics in elite runners was investigated. Seven middle-distance runners (6 men, 1 woman) belonging to the Swedish national team (mean age 23 years) spent 2 weeks of training at 2000 m above sea level in Kenya. Treadmill tests were performed before and 6 and 12 d after the altitude sojourn. Six other runners (4 men, 2 women) had a corresponding training sojourn at sea level in Portugal (control group). Ro of the runners (1 man, 1 woman) in the Kenya group were omitted from the study because of gastroenteritis. The maximal oxygen uptake (VO2 max; pretravel: Kenya group 212 and control group 188 ml · kg−0.75 - min−1), maximal treadmill time and oxygen cost of running were unchanged in both groups. The maximal oxygen deficit increased in all subjects after the Kenya sojourn (mean 19±6%). Heart rates during running at specified submaximal running velocities were lower post-altitude (Kenya group), but tended to be higher after sea-level training (control group). Maximal heart rate was unchanged in both groups. Perceived exertion (Borg) during submaximal running was lower post-altitude. Submaximal and maximal blood lactate and plasma catecholamine concentrations were not altered in any of the groups. Post-exhaustive plasma ammonia levels were decreased 12 d after altitude descent in the Kenya group. The results suggest an unchanged aerobic capacity in elite middle-distance runners after short-term training at moderate altitude. However, a change in the circulatory regulation during submaximal exercise was observed. Furthermore, anaerobic capacity improved but this bore no clear relation to lactate or ammonia metabolism.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Screw-shaped commercially pure (c.p.) niobium and c.p. titanium implants were inserted in rabbit bone. After a healing period of 3 months, a significantly higher removal torque was demonstrated to unscrew the niobium implants (average 32.9 Ncm) compared to the c.p. titanium implants (average 25.3 Ncm). In the histomorphometric part of the study, there were no significant differences in bone-to-metal contact between the 2 implant materials. An average of 41.1% bony contact was demonstrated for the niobium screws compared to an average of 37.2% for the c.p. titanium ones. Our removal torque findings could be related to the differences that we observed between the 2 implant surfaces as indicated by SEM. Since niobium implants showed a more irregular surface topography and niobium is a softer metal than c.p. titanium, this seems the most probable reason for the differences observed in removal torque between the 2 metals. Hypothetically, a more “positive biocom-patibility” of the c.p. niobium in comparison to the c.p. titanium remains as another possible reason for the observed differences. However, against such a difference in biocompatibility between c.p. niobium and c.p. titanium, there is the very similar amount of bony contact registered 1 in the histomorphometric analysis.
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