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  • 1
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cellular fatty acid-binding proteins (FABP) are a highly conserved family of proteins consisting of several subtypes, among them the mammary-derived growth inhibitor (MDGI) which is quite homologous to or even identical with the heart-type FABP (H-FABP). The FABPs and MDGI have been suggested to be involved in intracellular fatty acid metabolism and trafficking. Recently, evidence for growth and differentiation regulating properties of MDGI and H-FABP was provided. Using four affinity-purified polyclonal antibodies against bovine and human antigen preparations, the cellular localization of MDGI/H-FABP in human and mouse tissues and organs was studied. The antibodies were weakly cross-reactive with adipose tissue extracts known to lack H-FABP, but failed to react by Western blot analysis with liver-type FABP (L-FABP) and intestinal-type FABP (I-FABP). MDGI/H-FABP protein was mainly detected in myocardium, skeletal and smooth muscle fibres, lipid and/or steroid synthesising cells (adrenals, Leydig cells, sebaceous glands, lactating mammary gland) and terminally differentiated epithelia of the respiratory, intestinal and urogenital tracts. The results provide evidence that expression of H-FABP is associated with an irreversibly postmitotic and terminally differentiated status of cells. Since all the antisera employed showed spatially identical and qualitatively equal immunostaining, it is suggested that human, bovine and mouse MDGI/H-FABP proteins share highly homologous epitopes.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract.  This paper presents a detailed clinical description of phantom limbs and a neuronal network model that provides a comprehensive and parsimonious explanation of otherwise inexplicable or at least unrelated phenomena. Simulations of self-organizing feature maps (Kohonen networks) that had been trained to recognize input patterns were deprived of parts of their input in order to simulate partial deafferentation. This leads to reorganization processes that are shown to be driven by input noise. In patients with an amputated limb, this noise is generated by dorsal root ganglion sensory neurons which are known to fire irregularly upon laceration. According to this model, the long-standing debate concerning non-cortical vs. cortical contributions to the generation of the phenomenon of phantom limbs can be resolved in that it is the peripherally generated noise that causes cortical reorganization. The model can be tested and may have therapeutic implications.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract.  The different cortical visual cells exhibit a large repertoire of responses to sinusoidal gratings, depending on their receptive field structure and the stimulation parameters. It has been shown previously that the tuning curves and histogram shapes of cell responses are affected by subunit distances. One receptive field model (Spitzer and Hochstein 1985b) incorporated subunit distance but assigned it as a constant parameter, for ease of calculation. Here we investigate different tuning curve properties of various primary cortical cell types during testing of 10 deg of nonuniform distances of the receptive fields’ subunits. The effect of nonuniformity was compared for average responses, tuning curve shapes, maximum peak responses, and bandwidths across four cell types of different sizes. The shapes and other properties of tuning curves are usually found to be retained also when the degree of uniformity is not very high for most of the cell types. In addition, the effect of uniformity is compared across these different response properties. The maximum peak responses of the tuning curve are found to display a lower coefficient of variation than the bandwidth, for all cell types, for most degrees of uniformity.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract This paper presents a detailed clinical description of phantom limbs and a neuronal network model that provides a comprehensive and parsimonious explanation of otherwise inexplicable or at least unrelated phenomena. Simulations of self-organizing feature maps (Kohonen networks) that had been trained to recognize input patterns were deprived of parts of their input in order to simulate partial deafferentation. This leads to reorganization processes that are shown to be driven by input noise. In patients with an amputated limb, this noise is generated by dorsal root ganglion sensory neurons which are known to fire irregularly upon laceration. According to this model, the long-standing debate concerning non-cortical vs. cortical contributions to the generation of the phenomenon of phantom limbs can be resolved in that it is the peripherally generated noise that causes cortical reorganization. The model can be tested and may have therapeutic implications.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The different cortical visual cells exhibit a large repertoire of responses to sinusoidal gratings, depending on their receptive field structure and the stimulation parameters. It has been shown previously that the tuning curves and histogram shapes of cell responses are affected by subunit distances. One receptive field model (Spitzer and Hochstein 1985b) incorporated subunit distance but assigned it as a constant parameter, for ease of calculation. Here we investigate different tuning curve properties of various primary cortical cell types during testing of 10 deg of nonuniform distances of the receptive fields' subunits. The effect of nonuniformity was compared for average responses, tuning curve shapes, maximum peak responses, and bandwidths across four cell types of different sizes. The shapes and other properties of tuning curves are usually found to be retained also when the degree of uniformity is not very high for most of the cell types. In addition, the effect of uniformity is compared across these different response properties. The maximum peak responses of the tuning curve are found to display a lower coefficient of variation than the bandwidth, for all cell types, for most degrees of uniformity.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 784-787 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Long-term imaging of cultured Xenopus embryonic neurons (Fig. \d) reveals patterns of Ca2+ elevation through the Ca2+-sensitive period, during which removal of Ca2+ inhibits maturation of the rate of activation of delayed rectifier potassium current (7Kv) and the normal appearance of ...
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  • 7
    ISSN: 0935-6304
    Keywords: cis-13-Eicosenoic Acid (Paullinic Acid) ; Cyanolipids ; Fatty acids ; GLC-MS ; NMR spectroscopy ; Oxazoline derivatives ; Paullinia elegans Sapindaceae ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The fatty acids of the total lipids, triglycerides, and the cyanolipid of Paullinia elegans (Sapindaceae) have been analyzed as their methyl esters and 4,4-dimethyloxazoline derivatives by gas chromatography-mass spectrometry. It was shown that the gas chromatographic separation of the oxazoline derivatives was sufficient to ensure the correct identification of the monoenic fatty acid positional isomers. Stereochemistry of the double bonds has been confirmed by infrared and 13C-nuclear magnetic resonance (NMR) spectroscopy. cis-13-Eicosenoic Acid (Paullinic acid) (44.4%) and cis-11-octadecenoic acid (cis-vaccenic acid) (19.8%) were found to be the main components beside other monoenoic acid positional isomers. The cyanolipid of P. elegans was identified as 2,4-dihydroxy-3-methylenebutyronitrile derivative by IR, 1H-NMR, 13C-NMR spectroscopy and was quantified by 1H-NMR spectroscopy (71.4%).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 22 (1995), S. 0 
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In spite of the theoretical recognition regarding the role of coping as a moderator, empirical findings indicate that it has only a modest effect as such This study was designed, therefore, to examine the moderating effect of demographic variables (DV) on coping effectiveness, i e active cognitive coping, avoidance coping and active behavioural coping The study sample was comprised of 12 male and 65 female patients with rheumatoid arthritis who were treated in three outpatient clinics of large hospitals in Israel Findings suggest that demographic variables do play an important, and somewhat surprising, role in the effectiveness of coping strategies to temper psychological distress Of the various demographic variables studied, marital status was found to have a significant effect on active cognitive coping and avoidance coping, and adherence to a religious belief system was found to have a significant effect on avoidance coping The implications of the results for coping effectiveness are discussed
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 22 (1995), S. 0 
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study examines social support effect on stress and adaptation through the mediating effect of control Participants in the study were 12 male and 65 female rheumatoid arthritis patients who were being treated in the outpatient clinics of three large hospitals in Israel Findings suggest that social support did have a significant effect on stress and adaptation, though this effect was through the mediating effect of control and not as a buffer as was suggested previously Implications of the results for nursing science are discussed
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1335
    Keywords: PCNA ; c-erbB-2 ; Histopathology ; Prognosis ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of proliferating cell nuclear antigen (PCNA) and c-erbB-2 oncoprotein has been assessed in 471 women with breast cancer to evaluate their prognostic value as compared to conventional histopathological factors. In univariate analysis, high PCNA expression (≥20%) predicted a significantly worse survival in lymph-node-negative tumors (univariateP=0.031). However, the effect disappeared in multivariate analysis and the histological grade remained the only independent factor for this group. Despite its close correlation to histological grade (P〈0.001), PCNA expression discriminated subsets with different survival within the heterogeneous group of moderately differentiated tumors (univariateP=0.073, multivariateP=0.075). PCNA expression was not found to be a significant prognostic factor in lymph-node-positive tumors, thus it was of limited value for breast cancer patients as a whole. c-erbB-2 protein overexpression was associated with a worse survival (univariateP=0.019, multivariateP=0.057) for the entire group of patients. The effect was mainly attributed to the significance of c-erbB-2 as an independent factor in lymph-node-positive (up to three nodes, multivariateP=0.04; four or more nodes: multivariateP=0.017) and large tumors (〉2 cm: multivariateP=0.002). c-erbB-2 was without significance in lymph-node-negative patients. Though both factors might amplify the prognostic information for distinct patient subsets they do not achieve the strong prognostic value of conventional histopathological features in breast cancer.
    Type of Medium: Electronic Resource
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