μ-, δ-,and κ-opioids
Springer Online Journal Archives 1860-2000
Abstract Analgesic and suppressive effects of selective μ- (DAGO), δ- (DME), and κ- (DAKLI) opioid agonists are compared with those of aminopeptidase N and neutral endopeptidase RB101 in rats of WAG/G and Fischer-344 rats. Fischer-344 rats were more susceptible to suppressive effects of DAGO and analgesic effect of DME. It is concluded that in these rats peculiarities of the μ- and δ-opioid systems determine susceptibility to locomotor depression and analgesia, respectively. There is no correlation between effects of DAGO and RB101 in these strains. This implies that depressive effect of RB101 is not mediated though μ-opioid systems. In contrast, the effects of DMA on pain sensitivity in WAG/G and F-344 rats are opposite to those of RB101. This suggests that specific features in the activity of cerebral δ-OS can determine the sensitivity of RB101-induced analgesia.
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