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  • 1
    Publication Date: 2013-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Noorden, Richard -- Tollefson, Jeff -- Hayden, Erika Check -- Morello, Lauren -- Shen, Helen -- Butler, Declan -- Ledford, Heidi -- Witze, Alexandra -- Reich, Eugenie Samuel -- Schiermeier, Quirin -- Cyranoski, David -- England -- Nature. 2013 Dec 19;504(7480):344-9. doi: 10.1038/504344a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24352274" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomy/economics ; Atmosphere/chemistry ; Coronavirus Infections/epidemiology ; Disease Eradication ; Federal Government ; Fossils ; Genes ; HIV Infections/drug therapy ; History, 21st Century ; Hominidae/classification/genetics ; Humans ; Influenza A Virus, H7N9 Subtype/pathogenicity ; Neurosciences/economics/trends ; Patents as Topic/legislation & jurisprudence ; Poliomyelitis/epidemiology ; *Science/economics/history ; Stem Cell Research ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
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    Nature Publishing Group (NPG)
    Publication Date: 2013-03-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Mar 7;495(7439):22-4. doi: 10.1038/495022a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23467149" target="_blank"〉PubMed〈/a〉
    Keywords: Career Mobility ; Child ; Child Rearing ; Europe ; Financing, Organized/economics/organization & administration/statistics & ; numerical data ; Humans ; Leadership ; Mentors ; Research Personnel/economics/education/*statistics & numerical data ; Salaries and Fringe Benefits/economics/statistics & numerical data ; Science/education/*manpower ; Sex Distribution ; Sexism/*statistics & numerical data ; United States ; Women's Rights/economics/*statistics & numerical data
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    Nature Publishing Group (NPG)
    Publication Date: 2013-02-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Feb 21;494(7437):295. doi: 10.1038/494295a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23426305" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquatic Organisms/drug effects ; Ecology/*economics/*organization & administration ; Environmental Monitoring ; Financing, Organized/economics/organization & administration ; Gulf of Mexico ; Humans ; National Academy of Sciences (U.S.)/*organization & administration ; Peer Review, Research ; Petroleum Pollution/*adverse effects/*economics ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2013-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morello, Lauren -- Ledford, Heidi -- Shen, Helen -- Tollefson, Jeff -- Witze, Alexandra -- Zhang, Sarah -- England -- Nature. 2013 Oct 24;502(7472):419. doi: 10.1038/502419a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24153271" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antarctic Regions ; *Budgets ; Ecology/economics ; Expeditions/economics ; *Federal Government ; Morale ; Research/*economics ; Research Personnel/economics/psychology ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
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    Nature Publishing Group (NPG)
    Publication Date: 2013-07-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Jul 4;499(7456):17-8. doi: 10.1038/499017a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23823775" target="_blank"〉PubMed〈/a〉
    Keywords: Emigrants and Immigrants/education/*legislation & jurisprudence/statistics & ; numerical data ; Emigration and Immigration/*legislation & jurisprudence ; *Federal Government ; India ; Research Personnel/education/*legislation & jurisprudence ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
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    Nature Publishing Group (NPG)
    Publication Date: 2013-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Apr 11;496(7444):151. doi: 10.1038/496151a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23579658" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*anatomy & histology/*cytology ; Humans ; Imaging, Three-Dimensional/methods ; Mice ; Nerve Net/*anatomy & histology/*cytology ; Neural Pathways/anatomy & histology/cytology ; Neuroanatomical Tract-Tracing Techniques/methods ; Neuroanatomy/*methods
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2013-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Jul 25;499(7459):389. doi: 10.1038/499389a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23887409" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/cytology ; Cartilage/cytology ; Humans ; Mesenchymal Stromal Cells/*cytology ; Mesoderm/cytology ; Patient Advocacy ; Practice Guidelines as Topic ; Stem Cell Transplantation/ethics/*standards
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2013-05-03
    Description: We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and approximately 25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704730/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704730/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cancer Genome Atlas Research Network -- Kandoth, Cyriac -- Schultz, Nikolaus -- Cherniack, Andrew D -- Akbani, Rehan -- Liu, Yuexin -- Shen, Hui -- Robertson, A Gordon -- Pashtan, Itai -- Shen, Ronglai -- Benz, Christopher C -- Yau, Christina -- Laird, Peter W -- Ding, Li -- Zhang, Wei -- Mills, Gordon B -- Kucherlapati, Raju -- Mardis, Elaine R -- Levine, Douglas A -- 5U24CA143799-04/CA/NCI NIH HHS/ -- 5U24CA143835-04/CA/NCI NIH HHS/ -- 5U24CA143840-04/CA/NCI NIH HHS/ -- 5U24CA143843-04/CA/NCI NIH HHS/ -- 5U24CA143845-04/CA/NCI NIH HHS/ -- 5U24CA143848-04/CA/NCI NIH HHS/ -- 5U24CA143858-04/CA/NCI NIH HHS/ -- 5U24CA143866-04/CA/NCI NIH HHS/ -- 5U24CA143867-04/CA/NCI NIH HHS/ -- 5U24CA143882-04/CA/NCI NIH HHS/ -- 5U24CA143883-04/CA/NCI NIH HHS/ -- 5U24CA144025-04/CA/NCI NIH HHS/ -- P30 CA008748/CA/NCI NIH HHS/ -- P30 CA016086/CA/NCI NIH HHS/ -- P30 CA016672/CA/NCI NIH HHS/ -- P50 CA098258/CA/NCI NIH HHS/ -- U24 CA143799/CA/NCI NIH HHS/ -- U24 CA143835/CA/NCI NIH HHS/ -- U24 CA143840/CA/NCI NIH HHS/ -- U24 CA143843/CA/NCI NIH HHS/ -- U24 CA143845/CA/NCI NIH HHS/ -- U24 CA143848/CA/NCI NIH HHS/ -- U24 CA143858/CA/NCI NIH HHS/ -- U24 CA143866/CA/NCI NIH HHS/ -- U24 CA143867/CA/NCI NIH HHS/ -- U24 CA143882/CA/NCI NIH HHS/ -- U24 CA143883/CA/NCI NIH HHS/ -- U24 CA144025/CA/NCI NIH HHS/ -- U54 HG003067/HG/NHGRI NIH HHS/ -- U54 HG003079/HG/NHGRI NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- U54HG003067-11/HG/NHGRI NIH HHS/ -- U54HG003079-10/HG/NHGRI NIH HHS/ -- U54HG003273-10/HG/NHGRI NIH HHS/ -- England -- Nature. 2013 May 2;497(7447):67-73. doi: 10.1038/nature12113.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23636398" target="_blank"〉PubMed〈/a〉
    Keywords: Breast Neoplasms/genetics ; Chromosome Aberrations ; DNA Copy Number Variations/genetics ; DNA Mutational Analysis ; DNA Polymerase II/genetics ; DNA-Binding Proteins/genetics ; Endometrial Neoplasms/*classification/*genetics ; Exome/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Genome, Human/*genetics ; Genomics ; Humans ; Ovarian Neoplasms/genetics ; Signal Transduction ; Transcription Factors/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
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    Nature Publishing Group (NPG)
    Publication Date: 2013-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Nov 7;503(7474):26-8. doi: 10.1038/503026a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nature.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24201265" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotechnology/economics/trends ; *Brain/anatomy & histology/physiology ; Brain Mapping ; *Federal Government ; *Goals ; Humans ; Neurosciences/economics/organization & administration/*trends ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2013-11-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Helen -- England -- Nature. 2013 Nov 7;503(7474):14-5. doi: 10.1038/503014a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24201259" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified/*genetics ; *Disease Models, Animal ; Gene Targeting/methods ; Genetic Engineering/*methods ; Haplorhini/*genetics ; Humans ; Huntington Disease/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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