CaRLO — Cancer Research Library Online

1

Electronic Resource

Bronchogenic cyst appearing as a hepatic mass (2000)

Cerwenka, H. ; Uggowitzer, M. ; Bacher, H. ; [et al.]

Springer

Abdominal imaging 25 (2000), S. 86-88

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ISSN: 1432-0509

Keywords: Key words: Bronchogenic cyst—Foregut cyst—Liver cyst—Hepatic imaging—CA19-9—Hepatic mass.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Because bronchogenic cysts may be found in or near any organ derived from the embryonic foregut, they sometimes pose considerable diagnostic difficulties. We describe the plain chest X-ray, computed tomographic, and angiographic findings in a patient with elevated CA 19-9 and upper quadrant abdominal pain due to a cystic tumor appearing as a hepatic mass. Surgery and histology showed a bronchogenic cyst located in the lower lobe of the right lung.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1107/s002619910017

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Electronic Resource

Ligands for natural killer cell receptors: redundancy or specificity (2001)

Cerwenka, Adelheid ; Lanier, Lewis L.

Copenhagen : Munksgaard International Publishers

Immunological reviews 181 (2001), S. 0

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ISSN: 1600-065X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Summary: Several inhibitory and activating receptors involved in natural killer cell activation have been characterized. The increasing knowledge about their ligands, including classical MHC class I molecules, non-classical MHC class I molecules and MHC class I-related molecules, is shedding new light on the targets of innate immune recognition. While classical MHC class I molecules are constitutively expressed, some MHC class I-related (MIC) molecules, however, are stress-induced by ill-defined stimuli. Two families of ligands for the human activating NKG2D receptor have been identified. These are the MIC proteins encoded by two highly polymorphic genes within the MHC class I and the retinoic acid-inducible early gene-1-like (also designated UL16-binding) proteins encoded by genes outside the MHC. For the mouse NKG2D receptor, one family, containing at least five distinct ligands, has been described. A better understanding about how targets signal their distress, which renders them susceptible to natural killer (NK)-cell attack, will help to define the role of NK cells in antimicrobial and antitumor immunity and transplantation.Supported by NIH grants CA89294 and CA89189

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1034/j.1600-065X.2001.1810113.x

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Immunology. MULT1plying cancer immunity (2015)

A. Steinle ; A. Cerwenka

American Association for the Advancement of Science (AAAS)

In: Science. 348(6230): 45-6. doi: 10.1126/science.aaa9842.

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Publication Date: 2015-04-04

Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Steinle, Alexander -- Cerwenka, Adelheid -- New York, N.Y. -- Science. 2015 Apr 3;348(6230):45-6. doi: 10.1126/science.aaa9842.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Molecular Medicine, Goethe University, Frankfurt am Main, Germany. ; Innate Immunity Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. a.cerwenka@dkfz-heidelberg.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25838370" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; Carrier Proteins/*immunology ; Histocompatibility Antigens Class I/*immunology ; Killer Cells, Natural/*immunology ; NK Cell Lectin-Like Receptor Subfamily K/*immunology ; Neoplasms/*immunology

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Distinct human circulating NKp30+FcϵRI{gamma}+CD8+ T cell population exhibiting high natural killer-like antitumor potential [Immunology and Inflammation] (2018)

Margareta P. Correia, Ana Stojanovic, Katharina Bauer, Dilafruz Juraeva, Lars-Oliver Tykocinski, Hanns-Martin Lorenz, Benedikt Brors, Adelheid Cerwenka

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2018-06-27

Description: CD8+ T cells are considered prototypical cells of adaptive immunity. Here, we uncovered a distinct CD8+ T cell population expressing the activating natural killer (NK) receptor NKp30 in the peripheral blood of healthy individuals. We revealed that IL-15 could de novo induce NKp30 expression in a population of CD8+ T...

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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Natural killers join the fight against cancer (2018)

Cerwenka, A., Lanier, L. L.

American Association for the Advancement of Science (AAAS)

In: Science

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Publication Date: 2018-03-30

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Checkpoint inhibition: NK cells enter the scene (2018)

Ana Stojanovic; Adelheid Cerwenka

Nature Publishing Group (NPG)

In: Nature Immunology

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Publication Date: 2018-06-19

Description: Checkpoint inhibition: NK cells enter the scene Checkpoint inhibition: NK cells enter the scene, Published online: 18 June 2018; doi:10.1038/s41590-018-0142-y Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody–mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.

Print ISSN: 1529-2908

Electronic ISSN: 1529-2916

Topics: Biology , Medicine

Published by Nature Publishing Group (NPG)

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Antifungal Prophylaxis with Posaconazole Delayed-Release Tablet and Oral Suspension in a Real-Life Setting: Plasma Levels, Efficacy, and Tolerability [Clinical Therapeutics] (2018)

Lenczuk, D., Zinke-Cerwenka, W., Greinix, H., Wölfler, A., Prattes, J., Zollner-Schwetz, I., Valentin, T., Lin, T. C., Meinitzer, A., Hoenigl, M., Krause, R.

The American Society for Microbiology (ASM)

In: Antimicrobial Agents and Chemotherapy

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Publication Date: 2018-05-26

Description: We continuously determined posaconazole plasma concentrations (PPCs) in 61 patients with hematological malignancies receiving posaconazole (PCZ) delayed-release tablets (DRT; 48 patients; median duration of intake, 92 days) and PCZ oral solution (OS; 13 patients; median duration of intake, 124 days). PCZ DRT and OS antifungal prophylaxis was efficient and well tolerated. Thirty-four of 48 patients (71%) receiving DRT always had PPCs of 〉0.7 mg/liter, while 14 of 48 patients (29%) had at least one PPC of ≤0.7 mg/liter. In patients receiving OS, 4 of 13 patients (31%) always had PPCs of 〉0.7 mg/liter, 6 of 13 patients (46%) had at least one PPC of ≤0.7 mg/liter, and 3 (23%) patients never reached a PPC of 0.7 mg/liter. In patients with at least one determined PPC, the mean proportion of all PPCs of 〉0.7 mg/liter was 91% for PCZ DRT, whereas it was 52% for PCZ OS ( P = 0.001). In the per sample analysis, PPCs were significantly more likely to be 〉0.7 mg/liter in patients receiving DRT than in patients receiving OS (PPCs were 〉0.7 mg/liter in 91.4% [297/325] of patients receiving DRT versus 70.3% [85/121] of patients receiving OS; P 〈 0.001). Patients receiving PCZ DRT had higher proportions of PPCs of 〉0.7 mg/liter than patients receiving OS both in the per patient and in the per sample analyses. Two patients (3%) had side effects during PCZ prophylaxis, and one (2%) had fungal breakthrough infection. Therapeutic drug monitoring enables detection of extended periods of PPCs of ≤0.7 mg/liter (e.g., due to nonadherence or graft-versus-host disease), which may also be associated with the loss of protective intracellular PCZ concentrations, regardless of the PCZ formulation.

Print ISSN: 0066-4804

Electronic ISSN: 1098-6596

Topics: Biology , Medicine

Published by The American Society for Microbiology (ASM)

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