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  • 2015-2019  (39)
  • 1980-1984  (92)
  • 1955-1959  (9)
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  • 1
    Keywords: Life sciences ; Plant breeding ; Plant physiology ; Life sciences ; Plant Breeding/Biotechnology ; Plant Genetics & Genomics ; Plant physiology ; Springer eBooks
    Description / Table of Contents: Expression analysis and genome annotations with RNA sequencing -- The application of Next Generation Sequencing techniques to Plant Epigenomics -- Whole genome sequencing to identify genes and QTL in rice -- Variant calling using NGS data in European aspen (Populus tremula) -- Leafy Spurge Genomics: A Model Perennial Weed To Investigate Development, Stress Responses, And Invasiveness -- Utilization of NGS and proteomic-based approaches to gain insights on cellular responses to singlet oxygen and improve energy yields for bacterial stress adaptation -- Experimental evolution and next generation sequencing illuminate the evolutionary trajectories of microbes -- Plant carbohydrate active enzyme (CAZyme) repertoires: a comparative Study -- Metagenomics of Plant- Microbe Interactions -- Genes and trans-factors underlying embryogenic transition in plant soma-cells -- Bioinformatics tools to analyze the proteome and genome data -- High through-put transcriptome analysis of plant stress responses -- CNV and structural variation in plants: prospects of NGS Approaches
    Abstract: This work is a compiled catalogue of such findings, where several NGS technologies ranging from the genomics, transcriptomics, metagenomics, single cell genomics, QTL, patho-genomics and patho-transcriptomics have been applied to delineate the mystery of the associated mutations, biological pathway transitions, transcriptional fluxes and patterns of host associated or adaptations to certain climatic conditions. The aims and scope of this book focuses more on the biological underpinning to initiate the cross-talks across the traits acquired or lost during the course of evolution. The structured framework of the present volume provides the applicative point of view of the NGS technologies and demonstrates the conceptual way of linking the experimentation to the NGS technologies, to aid in researchers to place their biological hypothesis in a larger context
    Pages: XII, 241 p. 40 illus., 31 illus. in color. : online resource.
    ISBN: 9783319171579
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  • 2
    ISSN: 1432-1041
    Keywords: alpha-adrenergic blocker ; hypertension ; blood pressure ; pulse rate ; noradrenaline ; plasma renin activity ; plasma aldosterone ; dopamine-beta-hydroxylase ; E-643
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To determine whether E-643, a new α-blocking agent, would reduce the blood pressure, regardless of the posture, a 1 mg dose was given 3 times daily for 7 consecutive days, to 8 male and 7 female inpatients, aged 37–73 years, with essential hypertension. Blood pressure and pulse rate were measured daily in the supine, sitting and standing positions. Before and after the treatment with E-643, plasma levels of noradrenaline, adrenaline, dopamine-β-hydroxylase, renin and aldosterone were determined, samples being obtained with the subjects recumbent and after standing upright for 60 min. A significant reduction in the systolic and diastolic blood pressures was evident in the supine (172±31/100±12 → 151±28/89±14 mmHg), sitting (158±22/101±11 → 138±28/89±15 mmHg) and standing (153±32/103±21 → 129±31/89±20 mmHg) positions. The reduction in blood pressure remained unchanged throughout the period of administration of E-643. Pulse rate was not affected when the subjects were supine (67±10 → 69±10 beats/min), but was increased in the sitting (68±10 → 73±9 beats/min) and standing (73±10 → 81±11 beats/min) positions. The increased pulse rate tended to decline during continued administration of E-643. Treatment with E-643 produced no significant change in plasma levels of adrenaline, noradrenaline, dopamine-β-hydroxylase, renin and aldosterone. The antihypertensive effect of treatment was more prominent in the patients with higher levels of plasma catecholamines and dopamine-β-hydroxylase, and was less prominent in those with higher plasma renin and aldosterone. Two patients had temporary bouts of dizziness and visual disturbances, but there were no subjective complaints during treatment.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cyclic 3′, 5′-mononucleotide phosphodiesterase (cyclic nucleotide PDEase) activity was studied histo-and cytochemically in the retinal rod photoreceptor cells of the rat by means of a newly developed technique utilizing the intrinsic 5′ nucleotidase activity instead of an exogenous 5′ nucleotidase source (snake venom). Cyclic GMP and cyclic AMP were used as substrates. When cyclic GMP was used as a substrate, the intense activity of phosphodiesterase (PDEase) was distributed over the entire rod outer segments; reaction product was observed on the plasmalemma and on the disk membranes of the outer segments. A slight reaction was also observed on the plasmalemma of the inner segments. However, no precipitate was found in the perinuclear and synaptic regions of the rod photoreceptors. In contrast, when cyclic AMP was utilized as a substrate, a moderate reaction was seen in the synaptic region of the plexiform layer. The intensity of the reaction in the outer segments was much reduced in comparison to the results with cyclic GMP. The enzyme activity was almost completely inhibited by 2 mM 3-isobutyl-1-methylxanthine (IBMX) or 2 mM theophylline, which were potent inhibitors of PDEase. To confirm the propriety of our new cytochemical method, the localization of 5′ nucleotidase was also studied utilizing 5′ AMP or 5′ GMP as substrates. In contrast to the activity of cyclic nucleotide PDEase, the activity of 5′ nucleotidase was distributed on all membranes of the photoreceptors from the synaptic outer plexiform layer to the tip of outer segments. After inhibition of the intrinsic 5′ nucleotidase activity with the use of 1 mM Ni-ions or 10 mM NaF no demonstration of cyclic nucleotide PDEase activity was possible; the existence of intrinsic 5′ nucleotidase activity is necessary for the release of free phosphateions from 5′ AMP (5′ GMP), which are a prerequisite for the histochemical reaction. For comparison, some sections were incubated with the conventional cyclic nucleotide PDEase incubation medium containing snake venom from Ophiophagus hannah. With this conventional method, morphological preservation was extremely poor, and moreover, the reaction itself was weaker than that with the presently described method.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Periodical changes in Ca2+-ATPase and Mg2+-ATPase activity were observed cytochemically in the crayfish gastrolith epithelium during the molting cycle in relation to the calcium transport mechanism. The ATPase activity was demonstrated by a new one-step lead citrate method. The reaction products were mainly restricted to the matrix of type II cell mitochondria. The Ca2+-ATPase activity was intensely observed in two calcium moving stages, the small gastrolith period which indicates the beginning of gastrolith formation, and the aftermolt, when the calcified gastrolith has been dissolved in the stomach and then reabsorbed from the stomach epithelium into the newly formed soft exoskeleton through the blood. Although the intensity of reaction products of Mg2+-ATPase varied in each stage, the enzymatic activity was observed throughout all molting stages. Reaction products were observed in all mitochondria, basement membranes, apical cytoplasmic membranes, and in some lysosomes. In conclusion, periodical changes in the two types of ATPase activity were seen in the mitochondria of gastrolith epithelium during the molting cycle, but Ca2+-ATPase activity seemed to be more prominently synchronized to the calcium movement in the gastrolith epithelium than Mg2+-ATPase activity. These results provide the strong evidence that Ca2+-ATPase may act strongly in the calcium transport system of crayfish molting.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2307
    Keywords: Type C retrovirus-like particles ; Electron and immunohistological microscopy ; Human placentas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seventeen placentas from normal Japanese women, obtained from 15 full term gestations and at 2 earlier gestational periods, were observed by electron microscopy for the presence of type C retrovirus-like particles. Immature free and budding particles were found in 16 placentas including those obtained pre-term. Free virus-like particles were seen in the intercellular spaces and within the lysosomes of syncytiotrophoblasts of the chorionic villi. Forms budding from syncytiotrophoblasts were found in 3 cases. Coincident data with the electron microscopic observations were obtained by immunohistological methods. Specific positive staining with antisera against heterogeneic whole murine leukaemia virus were seen within the cytoplasm of trophoblastic cells both in and along the basal lamina.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-one patients with head and neck carcinomas relapsing after radiotherapy were treated with a combination of cis-platinum, bleomycin, and methotrexate. Four patients (19%) achieved a partial response. Toxicity was significant in selected cases; three patients developed WBC counts less than 1,000/mm3 and one of these patients died with sepsis. Severe mucositis was present in three of the twenty-one patients. Considering the toxicity of this combination and the limited therapeutic activity with the dose and schedule used in this study, this regimen is not recommended for the treatment of squamous head and neck carcinomas relapsing after radiotherapy.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 113 (1982), S. 641-643 
    ISSN: 1434-4475
    Keywords: 5H-Benzo[a]phenoxazin-5-one ; 6-Ethyl-5H-benzo[a]phenoxazin-5-one ; 6-Methyl-5H-benzo[a]phenoxazin-5-one
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung 6-Alkyl-5H-benzo[a]phenoxazin-5-one wurden mittels Reaktion von 5H-Benzo[a]phenoxazin-5-onen mit Carbonsäuren in Gegenwart von Silberionen und Peroxydisulfat dargestellt.
    Notes: Abstract 6-Alkyl-5H-benzo[a]phenoxazin-5-ones were prepared by the reaction of 5H-benzo[a]phenoxazin-5-one with carboxylic acid in the presence of silver ion and peroxydisulfate.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 112 (1981), S. 1459-1461 
    ISSN: 1434-4475
    Keywords: 5H-Benzo[a]phenoxazin-5-one ; 6-Propionyl-5H-benzo[a]-phenoxazin-5-one
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Titelverbindungen wurden mittels photochemischer Reaktion von 5H-Benzo[a]phenoxazin-5-onen mit Aldehyden hergestellt.
    Notes: Abstract 6-Acyl-5H-benzo[a]phenoxazin-5-ones were prepared by the photochemical reaction of 5H-benzo[a]phenoxazin-5-one with aldehydes.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-4475
    Keywords: 5 H-Benzo[a]phenothiazin-5-one ; 6-Bromo-5 H-benzo[a]phenothiazin-5-one ; 6-Chloro-5 H-benzo[a]phenothiazin-5-one ; 3 H-Phenothiazin-3-one
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung 6-Brom- und 6-Chlor-5H-benzo[a]phenothiazin-5-on lassen sich in wäßrigem Pyridin in Gegenwart von Natriumdithionit unter Stickstoff zu 5H-Benzo[a]phenothiazin-3-on enthalogenieren.
    Notes: Abstract 6-Bromo- and 6-chloro-5H-benzo[a]phenothiazin-5-ones were dehalinated to 5H-benzo[a]phenothiazin-5-one in the presence of sodium hydrosulfite (disodiumdithionite · 2H2O) dissolved in aqueous pyridine under nitrogen atmosphere.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 113 (1982), S. 855-857 
    ISSN: 1434-4475
    Keywords: Acetylphenoxazines ; Photochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung 1- und 3-Acetylphenoxazin wurden durch photochemische Reaktion aus 10-Acetylphenoxazin dargestellt.
    Notes: Abstract 1- and 3-Acetylphenoxazine were prepared by the photochemical reaction of 10-acetylphenoxazine.
    Type of Medium: Electronic Resource
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