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  • 2015-2019  (91)
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  • 1
    Keywords: Medicine ; Human Physiology ; Pharmacology ; Cardiology ; Biomedicine ; Pharmacology/Toxicology ; Cardiology ; Human Physiology ; Springer eBooks
    Description / Table of Contents: Introduction -- Epidemiology -- Clinical trial design, endpoints and regulatory requirements. Biomarkers HFpEF/HFrEF. Imaging Technologies / MRI and Echo. Comorbidities in HF. Current Guideline based therapy of HFreF and HFpEF. New and Emerging Therapies and Targets. Ivabradine -- Beta3 agonists -- Novel MRAs -- pGCs and Natriuretic peptides -- sGC stimulators -- PDE’s -- Adenosin and A1 Agonists -- Myosin heavy chain / Troponin -- Stem cells -- Diuretics and Vasopressin -- GeneTherapy -- RNA-based therapies and micro RNAs -- Cardiac myosin activation using gene therapy -- Bendavia – mitochondrial therapies -- WNT signaling -- Anticoagulation therapy and NOACS in HF -- Potassium Binders -- Iron
    Abstract: This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imaging technologies. The main focus of this book is to review current and emerging heart failure therapies and potential targets for treatment
    Pages: IX, 581 p. 100 illus., 30 illus. in color. : online resource.
    ISBN: 9783319596594
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  • 2
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    Nature Publishing Group (NPG)
    Publication Date: 2015-05-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2015 May 21;521(7552):269. doi: 10.1038/nature.2015.17560.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25993935" target="_blank"〉PubMed〈/a〉
    Keywords: Bangladesh ; Ethiopia ; Evaluation Studies as Topic ; Humans ; *International Cooperation ; Pilot Projects ; Poverty/*economics/*prevention & control/statistics & numerical data/trends ; Program Evaluation ; Random Allocation ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    Nature Publishing Group (NPG)
    Publication Date: 2015-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2015 Apr 16;520(7547):274-5. doi: 10.1038/520274a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25877183" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2016-03-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2016 Mar 10;531(7593):153. doi: 10.1038/nature.2016.19502.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26961637" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil/epidemiology ; Colombia/epidemiology ; Epidemiological Monitoring ; Female ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/*diagnosis/*epidemiology/virology ; Microcephaly/diagnosis/*epidemiology/*virology ; Pregnancy ; Zika Virus/*pathogenicity ; Zika Virus Infection/*complications/diagnosis/*epidemiology/virology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 5
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    Nature Publishing Group (NPG)
    Publication Date: 2016-04-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- England -- Nature. 2016 Apr 14;532(7598):155-6. doi: 10.1038/532155a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27075072" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/virology ; Angola/epidemiology ; Animals ; Asia/epidemiology ; Child ; Cities/epidemiology ; Disease Outbreaks/statistics & numerical data ; *Fear ; Haplorhini/virology ; Humans ; South America/epidemiology ; Strategic Stockpile/statistics & numerical data ; Vaccination/statistics & numerical data ; World Health Organization ; Yellow Fever/*epidemiology/*transmission/virology ; Yellow Fever Vaccine/administration & dosage/supply & distribution
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2016-01-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Butler, Declan -- Callaway, Ewen -- England -- Nature. 2016 Jan 21;529(7586):263-4. doi: 10.1038/nature.2016.19189.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26791697" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2016-05-03
    Description: We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nik-Zainal, Serena -- Davies, Helen -- Staaf, Johan -- Ramakrishna, Manasa -- Glodzik, Dominik -- Zou, Xueqing -- Martincorena, Inigo -- Alexandrov, Ludmil B -- Martin, Sancha -- Wedge, David C -- Van Loo, Peter -- Ju, Young Seok -- Smid, Marcel -- Brinkman, Arie B -- Morganella, Sandro -- Aure, Miriam R -- Lingjaerde, Ole Christian -- Langerod, Anita -- Ringner, Markus -- Ahn, Sung-Min -- Boyault, Sandrine -- Brock, Jane E -- Broeks, Annegien -- Butler, Adam -- Desmedt, Christine -- Dirix, Luc -- Dronov, Serge -- Fatima, Aquila -- Foekens, John A -- Gerstung, Moritz -- Hooijer, Gerrit K J -- Jang, Se Jin -- Jones, David R -- Kim, Hyung-Yong -- King, Tari A -- Krishnamurthy, Savitri -- Lee, Hee Jin -- Lee, Jeong-Yeon -- Li, Yilong -- McLaren, Stuart -- Menzies, Andrew -- Mustonen, Ville -- O'Meara, Sarah -- Pauporte, Iris -- Pivot, Xavier -- Purdie, Colin A -- Raine, Keiran -- Ramakrishnan, Kamna -- Rodriguez-Gonzalez, F German -- Romieu, Gilles -- Sieuwerts, Anieta M -- Simpson, Peter T -- Shepherd, Rebecca -- Stebbings, Lucy -- Stefansson, Olafur A -- Teague, Jon -- Tommasi, Stefania -- Treilleux, Isabelle -- Van den Eynden, Gert G -- Vermeulen, Peter -- Vincent-Salomon, Anne -- Yates, Lucy -- Caldas, Carlos -- Veer, Laura Van't -- Tutt, Andrew -- Knappskog, Stian -- Tan, Benita Kiat Tee -- Jonkers, Jos -- Borg, Ake -- Ueno, Naoto T -- Sotiriou, Christos -- Viari, Alain -- Futreal, P Andrew -- Campbell, Peter J -- Span, Paul N -- Van Laere, Steven -- Lakhani, Sunil R -- Eyfjord, Jorunn E -- Thompson, Alastair M -- Birney, Ewan -- Stunnenberg, Hendrik G -- van de Vijver, Marc J -- Martens, John W M -- Borresen-Dale, Anne-Lise -- Richardson, Andrea L -- Kong, Gu -- Thomas, Gilles -- Stratton, Michael R -- Nature. 2016 May 2. doi: 10.1038/nature17676.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. ; East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 9NB, UK. ; Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund University, Lund SE-223 81, Sweden. ; Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory, Los Alamos, NM 87545, New Mexico, USA. ; Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA. ; Department of Human Genetics, University of Leuven, B-3000 Leuven, Belgium. ; Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam 3015CN, The Netherlands. ; Radboud University, Department of Molecular Biology, Faculty of Science, 6525GA Nijmegen, The Netherlands. ; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. ; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo 0310, Norway. ; K. G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo 0310, Norway. ; Department of Computer Science, University of Oslo, Oslo, Norway. ; Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Incheon, South Korea. ; Translational Research Lab, Centre Leon Berard, 28, rue Laennec, 69373 Lyon Cedex 08, France. ; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ; The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. ; Breast Cancer Translational Research Laboratory, Universite Libre de Bruxelles, Institut Jules Bordet, Bd de Waterloo 121, B-1000 Brussels, Belgium. ; Translational Cancer Research Unit, Center for Oncological Research, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. ; Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. ; Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. ; Department of Pathology, Asan Medical Center, College of Medicine, Ulsan University, Ulsan, South Korea. ; Department of Pathology, College of Medicine, Hanyang University, Seoul 133-791, South Korea. ; Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA. ; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard., Houston, Texas 77030, USA. ; Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, Seoul, South Korea. ; Institut National du Cancer, Research Division, Clinical Research Department, 52 avenue Morizet, 92513 Boulogne-Billancourt, France. ; University Hospital of Minjoz, INSERM UMR 1098, Bd Fleming, Besancon 25000, France. ; Pathology Department, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. ; Oncologie Senologie, ICM Institut Regional du Cancer, Montpellier, France. ; The University of Queensland, UQ Centre for Clinical Research and School of Medicine, Brisbane, Queensland 4029, Australia. ; Cancer Research Laboratory, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland. ; IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy. ; Department of Pathology, Centre Leon Berard, 28 rue Laennec, 69373 Lyon Cedex 08, France. ; Department of Pathology, GZA Hospitals Sint-Augustinus, Antwerp, Belgium. ; Institut Curie, Paris Sciences Lettres University, Department of Pathology and INSERM U934, 26 rue d'Ulm, 75248 Paris Cedex 05, France. ; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. ; Breast Cancer Now Research Unit, King's College London, London SE1 9RT, UK. ; Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London SW3 6JB, UK. ; Department of Clinical Science, University of Bergen, 5020 Bergen, Norway. ; Department of Oncology, Haukeland University Hospital, 5021 Bergen, Norway. ; National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore. ; Singapore General Hospital, Outram Road, 169608, Singapore. ; Equipe Erable, INRIA Grenoble-Rhone-Alpes, 655, Avenue de l'Europe, 38330 Montbonnot-Saint Martin, France. ; Synergie Lyon Cancer, Centre Leon Berard, 28 rue Laennec, Lyon Cedex 08, France. ; Department of Genomic Medicine, UT MD Anderson Cancer Center, Houston, Texas 77230, USA. ; Department of Radiation Oncology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands. ; Pathology Queensland, The Royal Brisbane and Women's Hospital, Brisbane, Queensland 4029, Australia. ; Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, Texas 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27135926" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2016-01-23
    Description: Antimatter continues to intrigue physicists because of its apparent absence in the observable Universe. Current theory requires that matter and antimatter appeared in equal quantities after the Big Bang, but the Standard Model of particle physics offers no quantitative explanation for the apparent disappearance of half the Universe. It has recently become possible to study trapped atoms of antihydrogen to search for possible, as yet unobserved, differences in the physical behaviour of matter and antimatter. Here we consider the charge neutrality of the antihydrogen atom. By applying stochastic acceleration to trapped antihydrogen atoms, we determine an experimental bound on the antihydrogen charge, Qe, of |Q| 〈 0.71 parts per billion (one standard deviation), in which e is the elementary charge. This bound is a factor of 20 less than that determined from the best previous measurement of the antihydrogen charge. The electrical charge of atoms and molecules of normal matter is known to be no greater than about 10(-21)e for a diverse range of species including H2, He and SF6. Charge-parity-time symmetry and quantum anomaly cancellation demand that the charge of antihydrogen be similarly small. Thus, our measurement constitutes an improved limit and a test of fundamental aspects of the Standard Model. If we assume charge superposition and use the best measured value of the antiproton charge, then we can place a new limit on the positron charge anomaly (the relative difference between the positron and elementary charge) of about one part per billion (one standard deviation), a 25-fold reduction compared to the current best measurement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahmadi, M -- Baquero-Ruiz, M -- Bertsche, W -- Butler, E -- Capra, A -- Carruth, C -- Cesar, C L -- Charlton, M -- Charman, A E -- Eriksson, S -- Evans, L T -- Evetts, N -- Fajans, J -- Friesen, T -- Fujiwara, M C -- Gill, D R -- Gutierrez, A -- Hangst, J S -- Hardy, W N -- Hayden, M E -- Isaac, C A -- Ishida, A -- Jones, S A -- Jonsell, S -- Kurchaninov, L -- Madsen, N -- Maxwell, D -- McKenna, J T K -- Menary, S -- Michan, J M -- Momose, T -- Munich, J J -- Nolan, P -- Olchanski, K -- Olin, A -- Povilus, A -- Pusa, P -- Rasmussen, C O -- Robicheaux, F -- Sacramento, R L -- Sameed, M -- Sarid, E -- Silveira, D M -- So, C -- Tharp, T D -- Thompson, R I -- van der Werf, D P -- Wurtele, J S -- Zhmoginov, A I -- England -- Nature. 2016 Jan 21;529(7586):373-6. doi: 10.1038/nature16491.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Liverpool, Liverpool L697ZE, UK. ; Department of Physics, University of California at Berkeley, Berkeley, California 94720-7300, USA. ; Centre de Recherches en Physique des Plasmas (CRPP), Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. ; School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK. ; Cockcroft Institute, Sci-Tech Daresbury, Warrington WA4 4AD, UK. ; Centre for Cold Matter, Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2AZ, UK. ; Physics Department, European Organisation for Nuclear Research (CERN), CH-1211 Geneva 23, Switzerland. ; Department of Physics and Astronomy, York University, Toronto, Ontario M3J 1P3, Canada. ; Instituto de Fisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-972, Brazil. ; Department of Physics, Swansea University, Swansea SA2 8PP, UK. ; Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada. ; Department of Physics and Astronomy, Aarhus University, DK-8000 Aarhus C, Denmark. ; TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3, Canada. ; Department of Physics, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. ; Department of Physics, Stockholm University, SE-10691, Stockholm, Sweden. ; Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada. ; Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia V8P 5C2, Canada. ; Department of Physics and Astronomy, Purdue University, West Lafayette, Indiana 47907, USA. ; Soreq Nuclear Research Center, Yavne, 81800, Israel. ; Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4, Canada. ; ATAP, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26791725" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2015-01-17
    Description: The physiological and biomechanical requirements of flight at high altitude have been the subject of much interest. Here, we uncover a steep relation between heart rate and wingbeat frequency (raised to the exponent 3.5) and estimated metabolic power and wingbeat frequency (exponent 7) of migratory bar-headed geese. Flight costs increase more rapidly than anticipated as air density declines, which overturns prevailing expectations that this species should maintain high-altitude flight when traversing the Himalayas. Instead, a "roller coaster" strategy, of tracking the underlying terrain and discarding large altitude gains only to recoup them later in the flight with occasional benefits from orographic lift, is shown to be energetically advantageous for flights over the Himalayas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bishop, C M -- Spivey, R J -- Hawkes, L A -- Batbayar, N -- Chua, B -- Frappell, P B -- Milsom, W K -- Natsagdorj, T -- Newman, S H -- Scott, G R -- Takekawa, J Y -- Wikelski, M -- Butler, P J -- BB/FO15615/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2015 Jan 16;347(6219):250-4. doi: 10.1126/science.1258732.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Biological Sciences, Bangor University, Bangor, Gwynedd, UK. ; School of Biological Sciences, Bangor University, Bangor, Gwynedd, UK. c.bishop@bangor.ac.uk l.hawkes@exeter.ac.uk. ; Wildlife Science and Conservation Center of Mongolia, Ulaanbataar, Mongolia. ; Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada. ; Office of the Dean of Graduate Research, University of Tasmania, Tasmania, Australia. ; Mongolian Academy of Sciences, Ulaanbataar, Mongolia. ; Emergency Prevention System(EMPRES) Wildlife and Ecology Unit, Food and Agriculture Organization of the United Nations (FAO), Rome, Italy. ; Department of Biology, McMaster University, Ontario, Ontario, Canada. ; San Francisco Bay Estuary Field Station, Western Ecological Research Center, U.S. Geological Survey, Vallejo, CA 94592 USA. ; Max Planck Institut fur Ornithologie, Radolfzell, Germany. Department of Biology, University of Konstanz, Konstanz, Germany. ; School of Biosciences, University of Birmingham, Birmingham, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25593180" target="_blank"〉PubMed〈/a〉
    Keywords: *Altitude ; *Animal Migration ; Animals ; Biomechanical Phenomena ; Body Temperature ; Body Weight ; *Energy Metabolism ; Flight, Animal/*physiology ; Geese/*physiology ; Heart Rate ; Tibet ; Wings, Animal/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2018-11-21
    Description: Continuation of historical trends in crop yield are critical to meeting the demands of a growing and more affluent world population. Climate change may compromise our ability to meet these demands, but estimates vary widely, highlighting the importance of understanding historical interactions between yield and climate trends. The relationship between...
    Keywords: Sustainability Science
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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