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  • 2015-2019  (123)
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  • 1
    Keywords: Toxicology ; Biochemistry ; Pharmacology/Toxicology ; Medical Biochemistry ; Pharmacotherapy ; Springer Nature Living Reference
    Abstract: DDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume ́€žSafety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: ́€žMethods in Clinical Pharmacology". For the 2nd℗ edition, all the existing chapters will be revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases etc. etc. The complete work was new arranged
    Pages: : online resource.
    ISBN: 9783319566375
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  • 2
    Keywords: Toxicology ; Pharmacy ; Biochemistry ; Pharmacology/Toxicology ; Pharmacy ; Biochemistry, general ; Springer Nature Living Reference
    Abstract: The rapid progress in biology will continue to change the methodological approach to drug discovery in the coming years. Electronic media will continuously help researchers to access and share information. It is, however, becoming more and more evident that many young pharmacologists have only limited training in classical pharmacological methodologies. These long-standing and still highly relevant methods are simply not available in the electronic databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this gap by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies. The classical methods and the newest technologies, all in one book! The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this third edition, all existing chapters have been revised and completely updated. A large number of assays were added: we are now publishing two volumes. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis (formerly called activity of blood constituents), - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. Audience: Pharmacologists and Pharmacists in Academia and Industry
    Pages: LVIII, 2071 p. 5 illus. : online resource.
    ISBN: 9783642277283
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  • 3
    Keywords: Medicine ; Neurosciences ; Medicinal Chemistry ; Psychopharmacology ; Biomedicine ; Neurosciences ; Psychopharmacology ; Medicinal Chemistry ; Springer eBooks
    Description / Table of Contents: Preface -- Chemistry and structure-activity relationships of psychedelics -- Hallucinogens and serotonin 5-HT2A receptor-mediated signaling pathways -- Effects of hallucinogens on neuronal activity -- Interactions of Hallucinogens with the Glutamatergic System:℗ Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons -- The effects of hallucinogens on gene expression -- Effect of Hallucinogens on Unconditioned Behavior -- Hallucinogens in Drug Discrimination -- Phenomenology, structure and dynamic of psychedelic states -- Serotonergic hallucinogen-induced visual perceptual alterations -- New world tryptamine hallucinogens and the neuroscience of ayahuasca -- Experimental psychosis research and schizophrenia - similarities and dissimilarities in psychopathology -- A review of Hallucinogen Persisting Perception Disorder (HPPD) and an exploratory study of subjects claiming symptoms of HPPD -- Therapeutic applications of classic hallucinogens -- Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates
    Abstract: This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action.℗ Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds
    Pages: X, 430 p. 196 illus., 158 illus. in color. : online resource.
    ISBN: 9783662558805
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  • 4
    Call number: M030:12 ; Z070:435
    Pages: 599 p.
    Edition: 5. Aufl.
    ISBN: 9783846206256
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    M030:12 departmental collection or stack – please contact the library
    Z070:435 departmental collection or stack – please contact the library
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  • 5
    Unknown
    Berlin : Springer Spektrum
    Call number: M120:279
    Pages: xv, 302 p. : ill.
    ISBN: 9783662453322
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    M120:279 departmental collection or stack – please contact the library
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  • 6
    Call number: QV4:36(12)
    Keywords: Toxicology ; Pharmacology ; Poisoning
    Pages: xxviii, 1113 p. : ill.
    Edition: 12., überarb. Aufl.
    ISBN: 9783437425257
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    QV4:36(12) available
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  • 7
    Unknown
    Cham : Springer International Publishing
    Keywords: Medicine ; Pharmacology ; Pharmacy ; Biomedicine ; Biomedicine general ; Pharmacology/Toxicology ; Drug Safety and Pharmacovigilance ; Springer eBooks
    Abstract: The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc
    Pages: 32 illus., 20 illus. in color. eReference. : online resource.
    Edition: 4th ed. 2016.
    ISBN: 9783319053929
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  • 8
    Call number: WN440:30(4)
    Keywords: Nuclear Medicine / instrumentation ; Quality Control
    Pages: x, 287 p. : ill.
    Edition: 4., überarb. Aufl.
    ISBN: 9783708914121
    Signatur Availability
    WN440:30(4) on loan
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  • 9
    Unknown
    Bonn : Rheinwerk Publishing
    (SAP press)  
    Call number: M220:37
    Keywords: Business / Computer programs ; Management information systems
    Pages: 648 p. : ill.
    Edition: 5. Aufl.
    ISBN: 9783836244299
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    M220:37 departmental collection or stack – please contact the library
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  • 10
    Keywords: Pharmacology ; Occupational Medicine ; Medicine ; Chemistry ; Pharmacology/Toxicology ; Occupational Medicine/Industrial Medicine ; Biomedicine, general ; Safety in Chemistry, Dangerous Goods ; Springer Nature Living Reference
    Description / Table of Contents: Foreword -- Introduction -- Operation mode of regulatory toxicology -- Aims and institutions -- Aims and mission -- Application areas -- National and international collaboration -- Procedures and standards -- The regulatory process -- Quality assurance in regulatory toxcicology -- Toxicological risk assessment -- Methodological repertoire -- Toxicological tests -- Characterization of physicochemical parameters -- Examination of acute and chronic toxicity -- Examination of organ-toxicity and of laboratory parameters -- Specific tests for neurotox , immunotox, allergy, irritation, reprotox and carcinogenicity -- Toxicity testing in vitro -- New and future toxicological assays -- Computer-based prediction models -- Metabolism tests -- Toxicokinetic tests -- Toxicodynamic tests -- Omics -- International regulation for toxicological test procedures -- Data acquisition in humans -- Epidemiological methods -- Studies in volunteers -- Chemical analysis in toxicology (New) -- Toxicostatistics and models -- Statistical evaluation methods -- Dose-response analysis, identification of threshold levels -- Extrapolation-procedures for carcinogenic and non-carcinogenic compounds -- Probabilistic methods -- Toxicodynamic models -- Toxicokinetic models -- Estimation of exposure -- Exposure analysis for indoor contaminants -- Exposure scenarios -- Use of toxiological data -- Quality criteria for primary literature -- Data-mining -- Paradigms use in risk evaluation -- Toxicological paradigms -- Do carcinogens have a threshold dose? pro and contra -- Single compounds vs combination effects -- Biomolecules vs smaller chemicals -- Sensitive humans vs average persons -- Assessment paradigmas -- Extrapolation factors and safety factors -- Background exposure vs additional exposure in human biomonitoring -- Adverse effects vs non-adverse effects -- ADI vs MOS principle -- Precaution principle vs hazard control -- Hygienic vs toxicological approaches -- Protected property and protection level -- Risk characterization and risk evaluation -- The risk concept -- Current℗ role of the term "risk" -- Risk cycles -- Risk minimization in drug development -- Data required for risk evaluation -- Importance of physical-chemical properties -- Importance of intrinsic toxic properties -- Importance of metabolism and of mechanism of action -- Importance of the extrapolation to lower doses in risk assessment -- Importance of exposure level for risk assessment -- Risk characterization -- Risk assessment -- Elements of risk assessment -- Risk comparison -- Risk-benefit considerations -- Risk assessment in different jurisdictions -- Reach as a regulatory instrument (New) -- Risk management and risk communication -- Risk management -- Purpose of risk management -- Assessment of limit values -- Deduction of limit values in different areas -- Registration and approval -- Classification and labelling -- Monitoring unwanted exposures and effects -- Restrictions and prohibitions -- Observance of susceptible population groups -- The toxicological expert report -- Risk management in toxicological emergencies -- Risk communication and participation of affected people -- Institutionalized participation -- The technique of risk communication -- Dealing with diseases that have been attributed to chemical exposures -- Addendum: tables and lists -- Checklist: Toxicological risk assessment in practice -- Glossary and risk terms -- Limit values, guideline values, tables.-Proposed additional chapters on℗ Ethics in toxicology and expansion of the chapter dealing with℗ Immunotoxicology
    Abstract: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004.℗ Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference
    Pages: 1000 p. 360 illus., 180 illus. in color. : online resource.
    ISBN: 9783642362064
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