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  • 2015-2019  (2,107)
  • 1
    Keywords: Biochemistry ; Chemistry, Inorganic ; Cell Membranes ; Animal Biochemistry ; Inorganic Chemistry ; Membrane Biology ; Springer eBooks
    Description / Table of Contents: Membrane Transport Proteins and Receptors for Cadmium and Cadmium Complexes -- The Chemical Biology of Cadmium -- Interactions of Cadmium With Signaling Molecules -- Cell Organelles as Targets of Cadmium Toxicity -- Cadmium and its Impact on Genomic Stability
    Abstract: This book outlines the interaction of cadmium with the proteome and signalling molecules of mammalian cells. Chapters from expert contributors cover topics such as cadmium chemical biology, membrane receptors and transporters for cadmium and cadmium complexes, and targets of cadmium toxicity. Students and researchers working in bioinorganic chemistry will find this book an important account
    Pages: IX, 125 p. 13 illus., 9 illus. in color. : online resource.
    ISBN: 9783319896236
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  • 2
    Keywords: Otorhinolaryngology ; Neurosciences ; Otorhinolaryngology ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Preface -- Visual Influence on Auditory Perception -- Cue Combination Within a Bayesian Framework -- Toward a Model of Auditory-Visual Speech Intelligibility -- An Object-Based Interpretation of Audiovisual Processing -- Hearing in a “Moving” Visual World: Coordinate Transformations Along the Auditory Pathway -- Multisensory Processing in the Auditory Cortex -- Audiovisual Integration in the Primate Prefrontal Cortex -- Using Multisensory Integration to Understand the Human Auditory Cortex -- Combining Voice and Face Content in the Primate Temporal Lobe -- Neural Network Dynamics and Audiovisual Integration -- Cross-Modal Learning in the Auditory System -- Multisensory Processing Differences in Individuals with Autism Spectrum Disorder
    Abstract: Auditory behavior, perception, and cognition are all shaped by information from other sensory systems. This volume examines this multi-sensory view of auditory function at levels of analysis ranging from the single neuron to neuroimaging in human clinical populations. Visual Influence on Auditory Perception Adrian K.C. Lee and Mark T. Wallace Cue Combination within a Bayesian Framework David Alais and David Burr Toward a Model of Auditory-Visual Speech Intelligibility Ken W. Grant and Joshua G. W. Bernstein An Object-based Interpretation of Audiovisual Processing Adrian K.C. Lee, Ross K. Maddox, and Jennifer K. Bizley Hearing in a “Moving” Visual World: Coordinate Transformations Along the Auditory Pathway Shawn M. Willett, Jennifer M. Groh, Ross K. Maddox Multisensory Processing in the Auditory Cortex Andrew J. King, Amy Hammond-Kenny, Fernando R. Nodal Audiovisual Integration in the Primate Prefrontal Cortex Bethany Plakke and Lizabeth M. Romanski Using Multisensory Integration to Understand Human Auditory Cortex Michael S. Beauchamp Combining Voice and Face Content in the Primate Temporal Lobe Catherine Perrodin and Christopher I. Petkov Neural Network Dynamics and Audiovisual Integration Julian Keil and Daniel Senkowski Cross-Modal Learning in the Auditory System Patrick Bruns and Brigitte Röder Multisensory Processing Differences in Individuals with Autism Spectrum Disorder Sarah H. Baum Miller, Mark T. Wallace Adrian K.C. Lee is Associate Professor in the Department of Speech & Hearing Sciences and the Institute for Learning and Brain Sciences at the University of Washington, Seattle Mark T. Wallace is the Louise B McGavock Endowed Chair and Professor in the Departments of Hearing and Speech Sciences, Psychiatry, Psychology and Director of the Vanderbilt Brain Institute at Vanderbilt University, Nashville Allison B. Coffin is Associate Professor in the Department of Integrative Physiology and Neuroscience at Washington State University, Vancouver, WA Arthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College Park Richard R. Fay is Distinguished Research Professor of Psychology at Loyola University, Chicago
    Pages: XVI, 272 p. 70 illus., 49 illus. in color. : online resource.
    ISBN: 9783030104610
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  • 3
    New York, NY : Springer New York
    Keywords: Medicine ; Immunology ; Biomedicine ; Immunology ; Springer eBooks
    Description / Table of Contents: A Fungal Protease Model To Interrogate Allergic Lung Immunity -- Use of the Litomosoides sigmodontis Infection Model of Filariasis to study Type 2 Immunity -- Production of Hymenolepis diminuta in the Laboratory: An Old Research Tool With New Clinical Applications -- A Mouse Model of Peanut Allergy Induced By Sensitization through the Gastrointestinal Tract -- Induction and Characterization of the Allergic Eye Disease Mouse Model -- Isolation and Purification of Epithelial and Endothelial Cells from Mouse Lung -- In vitro and In vivo IgE/Antigen Mediated Mast Cell Activation -- The use of Human and Mouse Mast Cell and Basophil Cultures to Assess type-2 Inflammation -- Isolation and Identification of Group 2 Innate Lymphoid Cells in Settings of Type 2 Inflammation -- Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors -- Characterization of Thymic Development of Natural Killer T Cell Subsets by Multiparameter Flow Cytometry -- Characterization of Mouse gd T Cell Subsets in the Setting of type-2 Immunity -- The Identification of Allergen-derived T cell Epitopes -- Generation of Allergen-specific Tetramers for a Murine Model of Airway Inflammation -- The Generation and Use of Allergen-specific TCR Transgenic Animals -- Using Cytokine Reporter Mice to Visualize Type-2 immunity in vivo -- Live Imaging of IL-4 expressing T Follicular Helper Cells in Explanted Lymph Nodes -- Imaging Precision Cut Lung Slices to Visualize Leukocyte Localization and Trafficking -- Study of IgE-producing B cells using the Verigem Fluorescent Reporter Mouse -- Chromatin Preparation from Murine Eosinophils for Genome-wide Analyses -- A Sensitive and Integrated Approach to Profile Messenger RNA from Samples with Low Cell Numbers -- An Integrated and Semi-automated Micro-scaled Approach to Profile Cis-Regulatory Elements by Histone Modification ChIP-Seq for Large-scale Epigenetic Studies -- Library preparation for ATAC-sequencing of Mouse CD4+ T Cells Isolated from the Lung and Lymph Nodes after Helminth Infection -- Identification of Functionally-relevant microRNAs in the Regulation of Allergic Inflammation -- The Use of Biodegradable Nanoparticles for Tolerogenic Therapy of Allergic Inflammation -- Assessing the Mouse Intestinal Microbiota in Settings of type-2 Immune Responses -- The use of CRISPR-Cas9 Technology to Reveal Important Aspects of Human Airway Biology -- A Consistent Method to Identify and Isolate Mononuclear Phagocytes from Human Lung and Lymph Nodes -- Organoid Cultures for Assessing Intestinal Epithelial Differentiation and Function in Response to Type-2 Inflammation -- Utilization of Air-liquid Interface Cultures as an in vitro Model to Assess Primary Airway Epithelial Cell Responses to the Type 2 Cytokine Interleukin 13
    Abstract: This book provides researchers the opportunity to investigate type-2-associated diseases in their laboratories. Beginning with chapters describing various models of type-2 immunity, the volume then continues by detailing cellular protocols designed to identify, characterize, and assess the function of key adaptive and innate immune cells involved in type-2 inflammation; approaches to isolate and evaluate specific cellular subsets at the genetic, epigenetic, and molecular level; protocols to assess type-2 immunity and its relationship to organismal and metabolic systems (ex. Microbiome). This book concludes with a section that explores the use of primary human cells in evaluating relevance to the clinic. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Vital and authoritative, Type 2 Immunity: Methods and Protocols aims to provide a broad network of methods that can be used to develop a hypothesis and investigate its potential from bench to beside
    Pages: XVI, 434 p. 80 illus., 53 illus. in color. : online resource.
    ISBN: 9781493978960
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  • 4
    New York, NY : Springer New York
    Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Clearance of Maternal RNAs: Not a Mummy’s Embryo Anymore -- Link of Zygotic Genome Activation and Cell Cycle Control -- Role of MicroRNAs in Zygotic Genome Activation: Modulation of mRNA during Embryogenesis -- Gene Expression Analysis of Mammalian Oocytes and Embryos by Quantitative Real-Time RT-PCR -- Detection of miRNA in Mammalian Oocytes and Embryos -- Detection of Bidirectional Promoter-Derived IncRNAs from Small-Scale Samples using Pre-Amplification-Free Directional RNA-Seq Method -- Detection and Characterization of Small Non-Coding RNAs in Mouse Gametes and Embryos Prior to Zygotic Genome Activation -- Purification of Zygotically Transcribed RNA through Metabolic Labeling of Early Zebrafish Embryos -- RNA FISH to Study Zygotic Genome Activation in Early Mouse Embryos -- Detection of RNA Polymerase II in Mice Embryos during Zygotic Genome Activation using Immunocytochemistry -- Immunological Staining of Global Changes in DNA Methylation in the Early Mammalian Embryo -- Single Cell Restriction Enzyme-Based Analysis of Methylation at Genomic Imprinted Regions in Preimplantation Mouse Embryos -- Use of Chemicals to Inhibit DNA Replication, Transcription, and Protein Synthesis to Study Zygotic Genome Activation -- Targeted Gene Knockdown in Early Embryos using siRNA -- Generating Mouse Models using Zygote Electroporation of Nucleases (ZEN) Technology with High Efficiency and Throughput -- CRISPR/Cas9-Mediated Gene Targeting during Embryogenesis in Swine -- Potential Involvement of SCF-Complex in Zygotic Genome Activation during Early Bovine Embryo Development -- Use of Histone K-M Mutants for the Analysis of Transcriptional Regulation in Mouse Zygotes
    Abstract: This volume provides an overview of zygotic genome activation (ZGA) and the use of recent tools to elucidate the events that occur during ZGA. The chapters in this book cover topics such as: clearance of maternal RNAs, detection of miRNA in mammalian oocytes and embryos, RNA FISH to study ZGA in early mouse embryos, and CRISPR/Cas9-mediated gene targeting during embryogenesis in the mouse and pig. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Zygotic Genome Activation: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about practical approaches to monitor the changes seen during ZGA
    Pages: XI, 272 p. 51 illus., 41 illus. in color. : online resource.
    ISBN: 9781493969883
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  • 5
    Keywords: Medicine ; Neurosciences ; Neurology ; Neurosurgery ; Medical ethics ; Law ; Biomedicine ; Neurosciences ; Theory of Medicine/Bioethics ; Law, general ; Neurology ; Neurosurgery ; Springer eBooks
    Description / Table of Contents: Section I. Experimental Animal Research -- Ethical Issues Associated with the Use of Animal Experimentation in Behavioural Neuroscience Research -- The use of animal models in behavioural neuroscience research -- Does the goal justify the methods? Harm and Benefit in Neuroscience Research Using Animals -- A Framework for investigating animal consciousness -- Telos, Conservation of Welfare, and Ethical Issues in Genetic Engineering of Animals -- Would the elimination of the capacity to suffer evolve ethical dilemmas in experimental animal research? -- Section II. Clinical Research -- Ethics of human research in behavioral neuroscience: Overview of section II -- What́€™s special about the ethical challenges of studying disorders with altered brain activity? -- Effects of brain injury on moral agency: Ethical dilemmas in investigating human behavior -- Genetic testing and neuroimaging for youth at risk for mental illness: Trading off benefit and risk -- Externalization of consciousness: Scientific possibilities and clinical implications -- How does enhancing cognition affect human values?℗ How does this translate into social responsibility? -- Deep brain stimulation: A principled and pragmatic approach to understanding the ethical and clinical challenges of an evolving technology -- Ethical issues and ethical therapy associated with anxiety disorders -- Just like a circus: The public consumption of sex differences -- Money and morals: Ending clinical trials for financial reasons
    Abstract: Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants
    Pages: VIII, 320 p. 7 illus., 3 illus. in color. : online resource.
    ISBN: 9783662448663
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  • 6
    Keywords: Life sciences ; Plant Biochemistry ; Plant Ecology ; Plant anatomy ; Plant development ; Plant breeding ; Life sciences ; Plant Anatomy/Development ; Plant Systematics/Taxonomy/Biogeography ; Plant Breeding/Biotechnology ; Plant Biochemistry ; Plant Ecology ; Springer eBooks
    Description / Table of Contents: Part I: Orchid Seeds in Plant Propagation and Conservation -- Understanding Seed and Protcorm Development in Orchids.-℗ Orchid Mycorrhizal Fungi:℗ Isolation and Identification Techniques -- Protocols for Establishing Fungi-Protocorm Culture -- Orchid Seed and Pollen: A Tool-kit for Long-term Storage, Viability Assessment and Conservation -- Part II: Orchid Micropropagation -- Orchid Seed Germination and Micropropagation I: Background information and Related Protocols -- Orchid Seed Germination and Micropropagation II: Media information and Composition -- Orchid Micropropagation: An Overview of Approaches and Methodologies -- Common Protocols in Orchid Micropropagation -- Micropropagation of Orchids by Using Bioreactor Technology -- Enhanced Growth and Development of Cymbidium and Phalaenopsis Plantlets Cultured in vitro Under Light-emitting Diodes -- Part III: Special Techniques -- Tracking Pollen Fates in Orchid Populations -- Cut-column Pollination Method to Overcome Pollination Barrier in Phalaenopsis -- In vitro Flowering and Breeding of Erycina pusilla -- Virus Elimination through Meristem Culture and Rapid Clonal Propagation Using a Temporary Immersion System -- Cryopreservation -- Haploid Seed Formation via Parthenogenesis in Bletilla -- A Protocol for the Induction of Polyploids in Phalaenopsis Orchids by in vitro Method without Using Anti-microtubule Agents -- Virus Detection -- Part IV: Cell and Molecular Biology and Transformation -- Genetic Transformation on Orchid species: An Overview of Approaches and Methodologies -- Recent Protocols on Genetic Transformation of Orchid Species -- The Use of Laser Microdissection to Investigate Cell Specific Gene Expression in Orchid Tissues -- Part V: Orchid Propagation and Maintenance -- Vegetative Propagation of Orchids -- Orchid Cultivation in Taiwan: Conventional and Innovative Methods -- Strategies in Orchid Health Maintenance -- Part VI: Showcasing Orchids -- Macro Flower Photography: An Introduction to Photographic Principles and Techniques -- An Introduction to Chinese Orchid Paintings -- Recent Advances in Orchid Seed Germination and Micropropagation
    Abstract: The orchid family is one of the largest families of flowering plants known for their beauty and economic importance.℗ This work provides information in key areas of research that are important to both scientists and commercial growers alike. The main purposes of this book are to provide key practical areas of research, such as, germination, micropropagation, traditional and current techniques related to plant improvement; document methods that ensure survival of plants from laboratories to greenhouses; promote communication between scientists and growers, so that their combined expertise on these areas will lead to the successful growth of orchids in their natural habitats or commercial greenhouses. This book can serve as reference for laymen with an interest in orchid growing. This book is divided into 5 parts. The first part emphasizes propagation methods using seeds and related techniques that are important to plant conservation and improvement. Successes in asymbiotic and symbiotic seed germination are keys to orchid conservation and their propagation.℗ The second part summarizes micropropagation methods, common media, and newer methods of micropropagation such as the bioreactor culture procedures. The third part focuses on techniques related to the manipulation of explants in an℗ in vitro℗ environment. The fourth part covers cell biological methods and transformation techniques. Since the successes in a laboratory setting do not guarantee plant survival and propagation in greenhouses and in the natural environment, it discusses greenhouse propagation techniques that are essential to the survival of plants generated from a laboratory setting. The fifth part showcases recent successes on orchid propagation by documenting sample publications and how to present orchids in an artistic fashion for on這s enjoyment
    Pages: XI, 524 p. 151 illus., 134 illus. in color. : online resource.
    ISBN: 9781493977710
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  • 7
    Keywords: Polymers ; Nanotechnology ; Botany ; Polymer Sciences ; Nanotechnology ; Plant Sciences ; Springer eBooks
    Description / Table of Contents: Chapter1. Introduction of Stimuli-Responsive Wetting/Dewetting Smart Surfaces and Interfaces -- Part 1. Stimuli-Responsive Dewetting/Wetting Surfaces/Interfaces. Chapter 2. Photo-Responsive Superwetting Surface -- Chapter 3. pH Responsive Reversibly Tunable Wetting Surfaces -- Chapter 4. Thermal-Responsive Superwetting Surface -- Chapter 5. Electric-Responsive Superwetting Surface -- Chapter6. Liquids on Shape-Tunable Wrinkles -- Chapter7. Solvent Response -- chapter8. Magnetic-Responsive Superwetting Surface -- Part 2. Practical Applications. chapter 9. Stimuli-Responsive Smart Surfaces for Oil/Water Separation Applications -- Chapter 10. Anti-(bio)Fouling -- Chapter 11. Toward Eadaptive Anti-icing Coating -- Chapter 12. Stimulus-Responsive Soft Surface/Interface Toward Applications in Adhesion, Sensor and Biomaterial -- Chapter 13. Liquid manipulation -- Chapter14. Material-Independent Surface Modification Inspired by Principle of Mussel Adhesion -- Chapter 15. Stimuli-Responsive Mussel-inspired Polydopamine Material
    Abstract: Superhydrophobic surfaces, artificially mimicking lotus leaves, have captured the attention of scientists and engineers over the past few decades. Recent trends have shifted from superhydrophobicity to superominipohobicity, or superamphiphobicity. In addition, dynamic rather than static surface wetting/dewetting properties, which can be triggered by various stimuli, including temperature, pH, magnetic/electric fields, solvents, light exposure etc, have been highly sought after for commercial applications. This book will focus on recent topics related to various stimuli-responsive wetting/dewetting surfaces, and give an overview of the knowledge and concepts of how to design and establish these smart artificial surfaces, which can be used for technical developments in a wide variety research fields
    Pages: XI, 464 p. 299 illus., 192 illus. in color. : online resource.
    ISBN: 9783319926544
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  • 8
    Call number: C071:3
    Keywords: Biomedical Research / methods
    Pages: xvii, 806 pages : ill.
    Edition: Fourth edition.
    ISBN: 9780128499054
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  • 9
    Keywords: Life sciences ; Human Genetics ; Biostatistics ; Microbial genetics ; Microbial genomics ; Life sciences ; Microbial Genetics and Genomics ; Human Genetics ; Biostatistics ; Springer eBooks
    Description / Table of Contents: Part I: overview -- 1. NGS, The new gold standard of identification of defective genes -- 2. Principles of target gene enrichments, pros and cons -- 3. Criteria for clinical application: Full validation and performance characteristics -- 4. Clinical requirements: variant interpretation, confirmation, and turnaround time -- Part II: Experiences in various applications -- 5. The metabolic pathways: GSD, CDG, cobalamin metabolism, and others -- 6. The eye gene panels -- 7. The otogenes -- 8. The immunodeficiency disorders -- 9. The bone density and skeletal related disorders -- 10.The hereditary cancer genes -- 11.The molecular diagnosis of cancers and implications in treatment: Marilyn Li -- 12. Neuromuscular disorders -- 13. The cardiac panel: YuXin Fan, GeneDx or Harvard Partner -- 14. The mitochondrial genome -- 15. The Nuclear Mitomes
    Abstract: Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application
    Pages: VIII, 364 p. 23 illus., 17 illus. in color. : online resource.
    ISBN: 9783319564180
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  • 10
    Keywords: Medicine ; Neurosciences ; Bioinformatics ; Neurobiology ; Biomedicine ; Neurosciences ; Computational Biology/Bioinformatics ; Neurobiology ; Springer eBooks
    Description / Table of Contents: Part I. Non-invasive Brain-Computer Interface -- Chapter 1. Future directions for brain-machine interfacing technology -- Chapter 2. Brain-Computer Interface for Smart Vehicle: Detection of Braking Intention during Simulated Driving -- Chapter 3. Benefits and limits of multimodal neuroimaging for Brain Computer Interfaces -- Chapter 4. Multifrequency Analysis of Brain-Computer Interfaces -- Part II. Cognitive- and Neural-rehabilitation Engineering -- Chapter 5. Current Trends in Memory Implantation and Rehabilitation -- Chapter 6. Moving Brain Controlled Devices Outside the Lab: Principles and Applications -- Part III. Big Data Neurocomputing -- Chapter 7. Across cultures: a Cognitive and Computational Analysis of Emotional and Conversational Facial Expressions in Germany and Korea -- Chapter 8. Bottom-Up Processing in Complex Scenes: a unifying perspective on segmentation, fixation saliency, candidate regions, base-detail decomposition, and image enhancement -- Chapter 9. Perception-based motion cueing: a Cybernetics approach to motion simulation -- Chapter 10. The other-race effect revisited: no effect for faces varying in race only -- Part IV. Early Diagnosis and Prediction of Neural Diseases -- Chapter 11. Functional neuromonitoring in acquired head injury -- Chapter 12. Diagnostic Optical Imaging Technology and its Principles -- Chapter 13. Detection of Brain Metastases using Magnetic Resonance Imaging -- Chapter 14. Deep Learning in Diagnosis of Brain Disorders
    Abstract: Brain and Cognitive Engineering is a converging study field to derive a better understanding of cognitive information processing in the human brain, to develop ́€œhuman-lik逝 and neuromorphic artificial intelligent systems and to help predict and analyze brain-related diseases. The key concept of Brain and Cognitive Engineering is to understand the Brain, to interface the Brain, and to engineer the Brain. It could help us to understand the structure and the key principles of high-order information processing on how the brain works, to develop interface technologies between a brain and external devices and to develop artificial systems that℗ can ultimately mimic human brain functions. The convergence of behavioral, neuroscience and engineering research could lead us to advance health informatics and personal learning, to enhance virtual reality and healthcare systems, and to ́€œreverse engineeŕ€ some brain functions and build cognitive robots. In this book, four different recent research directions are presented: Non-invasive Brain-Computer Interfaces, Cognitive- and Neural-rehabilitation Engineering, Big Data Neurocomputing, Early Diagnosis and Prediction of Neural Diseases. We cover numerous topics ranging from smart vehicles and online EEG analysis, neuroimaging for Brain-Computer Interfaces, memory implantation and rehabilitation, big data computing in cultural aspects and cybernetics to brain disorder detection. Hopefully this will provide a valuable reference for researchers in medicine, biomedical engineering, in industry and academia for their further investigations and be inspiring to those who seek the foundations to improve techniques and understanding of the Brain and Cognitive Engineering research field
    Pages: XI, 213 p. 73 illus., 56 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9789401772396
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