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  • 1
    Publication Date: 2012-03-31
    Description: Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cancer cell lines--which represent much of the tissue-type and genetic diversity of human cancers--with 130 drugs under clinical and preclinical investigation. In aggregate, we found that mutated cancer genes were associated with cellular response to most currently available cancer drugs. Classic oncogene addiction paradigms were modified by additional tissue-specific or expression biomarkers, and some frequently mutated genes were associated with sensitivity to a broad range of therapeutic agents. Unexpected relationships were revealed, including the marked sensitivity of Ewing's sarcoma cells harbouring the EWS (also known as EWSR1)-FLI1 gene translocation to poly(ADP-ribose) polymerase (PARP) inhibitors. By linking drug activity to the functional complexity of cancer genomes, systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349233/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349233/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garnett, Mathew J -- Edelman, Elena J -- Heidorn, Sonja J -- Greenman, Chris D -- Dastur, Anahita -- Lau, King Wai -- Greninger, Patricia -- Thompson, I Richard -- Luo, Xi -- Soares, Jorge -- Liu, Qingsong -- Iorio, Francesco -- Surdez, Didier -- Chen, Li -- Milano, Randy J -- Bignell, Graham R -- Tam, Ah T -- Davies, Helen -- Stevenson, Jesse A -- Barthorpe, Syd -- Lutz, Stephen R -- Kogera, Fiona -- Lawrence, Karl -- McLaren-Douglas, Anne -- Mitropoulos, Xeni -- Mironenko, Tatiana -- Thi, Helen -- Richardson, Laura -- Zhou, Wenjun -- Jewitt, Frances -- Zhang, Tinghu -- O'Brien, Patrick -- Boisvert, Jessica L -- Price, Stacey -- Hur, Wooyoung -- Yang, Wanjuan -- Deng, Xianming -- Butler, Adam -- Choi, Hwan Geun -- Chang, Jae Won -- Baselga, Jose -- Stamenkovic, Ivan -- Engelman, Jeffrey A -- Sharma, Sreenath V -- Delattre, Olivier -- Saez-Rodriguez, Julio -- Gray, Nathanael S -- Settleman, Jeffrey -- Futreal, P Andrew -- Haber, Daniel A -- Stratton, Michael R -- Ramaswamy, Sridhar -- McDermott, Ultan -- Benes, Cyril H -- 086357/Wellcome Trust/United Kingdom -- 1U54HG006097-01/HG/NHGRI NIH HHS/ -- P41GM079575-02/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Mar 28;483(7391):570-5. doi: 10.1038/nature11005.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22460902" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects/*genetics ; *Drug Screening Assays, Antitumor ; Gene Expression Regulation, Neoplastic/genetics ; Genes, Neoplasm/*genetics ; Genetic Markers/*genetics ; Genome, Human/*genetics ; Genomics ; Humans ; Indoles/pharmacology ; Neoplasms/*drug therapy/*genetics/pathology ; Oncogene Proteins, Fusion/genetics ; Pharmacogenetics ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors ; Proto-Oncogene Protein c-fli-1/genetics ; RNA-Binding Protein EWS/genetics ; Sarcoma, Ewing/drug therapy/genetics/pathology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2012-01-20
    Description: Agricultural expansion and climate variability have become important agents of disturbance in the Amazon basin. Recent studies have demonstrated considerable resilience of Amazonian forests to moderate annual drought, but they also show that interactions between deforestation, fire and drought potentially lead to losses of carbon storage and changes in regional precipitation patterns and river discharge. Although the basin-wide impacts of land use and drought may not yet surpass the magnitude of natural variability of hydrologic and biogeochemical cycles, there are some signs of a transition to a disturbance-dominated regime. These signs include changing energy and water cycles in the southern and eastern portions of the Amazon basin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davidson, Eric A -- de Araujo, Alessandro C -- Artaxo, Paulo -- Balch, Jennifer K -- Brown, I Foster -- C Bustamante, Mercedes M -- Coe, Michael T -- DeFries, Ruth S -- Keller, Michael -- Longo, Marcos -- Munger, J William -- Schroeder, Wilfrid -- Soares-Filho, Britaldo S -- Souza, Carlos M Jr -- Wofsy, Steven C -- England -- Nature. 2012 Jan 18;481(7381):321-8. doi: 10.1038/nature10717.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Woods Hole Research Center, 149 Woods Hole Road, Falmouth, Massachusetts 02540-1644, USA. edavidson@whrc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22258611" target="_blank"〉PubMed〈/a〉
    Keywords: Brazil ; *Carbon Cycle ; *Climate Change ; Droughts ; *Ecosystem ; Fires ; Forestry ; Rain ; Rivers ; Seasons ; Trees/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2012-03-01
    Description: The immune system protects from infections primarily by detecting and eliminating the invading pathogens; however, the host organism can also protect itself from infectious diseases by reducing the negative impact of infections on host fitness. This ability to tolerate a pathogen's presence is a distinct host defense strategy, which has been largely overlooked in animal and human studies. Introduction of the notion of "disease tolerance" into the conceptual tool kit of immunology will expand our understanding of infectious diseases and host pathogen interactions. Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564547/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564547/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Medzhitov, Ruslan -- Schneider, David S -- Soares, Miguel P -- 1DP1OD008167-01/OD/NIH HHS/ -- R01 AI055502/AI/NIAID NIH HHS/ -- R01 DK071754/DK/NIDDK NIH HHS/ -- R01AI055502/AI/NIAID NIH HHS/ -- R01AI060164/AI/NIAID NIH HHS/ -- R01DK071754/DK/NIDDK NIH HHS/ -- R37 AI046688/AI/NIAID NIH HHS/ -- R37AI046688/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):936-41. doi: 10.1126/science.1214935.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. ruslan.medzhitov@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22363001" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Disease Resistance ; Disease Susceptibility ; *Host-Pathogen Interactions ; Humans ; *Immunity, Innate ; Infection/*immunology/pathology/physiopathology ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-04-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soares-Filho, Britaldo -- Rajao, Raoni -- Macedo, Marcia -- Carneiro, Arnaldo -- Costa, William -- Coe, Michael -- Rodrigues, Hermann -- Alencar, Ane -- New York, N.Y. -- Science. 2014 Apr 25;344(6182):363-4. doi: 10.1126/science.1246663.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-901, Brazil.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24763575" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Brazil ; Conservation of Natural Resources/*legislation & jurisprudence ; Ecosystem ; Public Policy ; *Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    London : Henry Stewart Talks
    Keywords: Host-parasite relationships ; Immunity ; Inflammation ; Evolution, Biological ; Heme Oxygenase-1 ; Host-Parasite Interactions ; Host-Pathogen Interactions ; Immunity ; Inflammation ; Plasmodium
    Description / Table of Contents: Contents: Host defense strategies against pathogenic microorganisms and parasites -- Expression of stress-responsive genes provide tissue damage control, uncoupling different forms of stress associated with inflammation and immunity from tissue damage and disease -- Tissue damage control confers host tolerance to infection -- Heme oxygenase-1 is a stress-responsive gene that provides tissue damage control -- Heme oxygenase-1 confers host tolerance to Plasmodium infection -- Preservation of Heme oxygenase-1 system during human evolution
    Notes: Animated audio-visual presentation with synchronized narration.
    Pages: 1 streaming video file (42 min.) : digital, mono., SWF file, sd., col.
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