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  • 2005-2009  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is well-established that light pulses regulate components of the extracellular signal-regulated kinases I/II (ERK) cascade in the suprachiasmatic nuclei (SCN) circadian clock. These events are important for photic-resetting of the circadian clock. The SCN circadian clock is also reset by pulses of dark, but it is unknown if this stimulus alters the activity of ERK, the transcription factor Elk-1 or expression of the immediate early gene c-fos in the SCN. Using Syrian hamsters free-running in constant light, we determined the effects of dark pulses on these factors in the SCN. In constant light, levels of phosphorylated ERK (P-ERK) showed significant circadian variation in the Syrian hamster SCN, while levels of c-Fos or phosphorylated Elk-1 (P-Elk-1) did not. A 6-h dark pulse beginning at circadian time (CT) 8 down-regulated expression of P-ERK and c-Fos, but not P-Elk-1, in the SCN. Following termination of the pulse, levels of c-Fos increased above time-matched control values, while P-ERK expression did not. When given at the beginning of the subjective night (CT13), a 6-h dark pulse did not phase-shift behavioural rhythms and failed to alter the expression of c-Fos, P-ERK, or P-Elk-1 in the SCN. At the level of the visual thalamus, expression of c-Fos in the intergeniculate leaflet was higher during the subjective night as compared to the subjective day, although dark pulses had no robust effects on expression of c-Fos or P-ELK-1 in this structure. We conclude that dark-pulse resetting of the circadian clock is complex and involves both non-photic and photic components.
    Type of Medium: Electronic Resource
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