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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report three patients newly diagnosed as having xeroderma pigmentosum (XP). Previous photobiological studies have implicated ultraviolet (UV) B as the activating waveband in XP, causing a delayed and prolonged erythemal response. This characteristic reaction pattern has been used as a quick screening test in patients suspected of having XP, while awaiting confirmatory DNA repair studies. Two of our patients showed no abnormal erythemal responses, and one showed severe photosensitivity from 330 to 400 nm but normal UVB responses, with a peak erythema at 24 h. We conclude that the erythemal responses in XP are highly variable and cannot be considered as a reliable screening test in the diagnosis of XP.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0789
    Keywords: Key words Polyphenols ; Feed quality ; Manure quality ; Decomposition ; Nutrient mineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  Farmers in developing countries cannot afford inorganic fertilizers. Multipurpose tree leaves or livestock manure are major sources of nutrients for soil fertility replenishment. Nutrient release from these organic inputs depends on their chemical composition and on soil properties. This study determined the chemical composition of leaves of four African browse species and manure from goats fed leaves as protein supplements, and their mineralization of C, N and P. Cumulative evolved CO2 was significantly correlated with the initial N content of the organic inputs (r 0.83, P〈0.05) and the C : N ratio (r 0.80, P〈0.05), and was negatively correlated with the lignin : N ratio (r–0.71, P〈0.05). Cumulative P released was negatively correlated with the C : P ratio (r 0.76, P〈0.05) and positively correlated with initial P content of the organic amendments (r 0.76, P〈0.05). Cumulative N mineralized was not significantly correlated with initial N, lignin or P concentrations of the organic inputs. Leaves from Acacia karro and Acacia nilotica had high concentrations of polyphenols, which may have caused immobilization of N in both leaves and manure. Gliricidia sepium leaves had low amounts of soluble polyphenols, a high N content and a high rate of N mineralization, but the manure from goats fed Gliricidia leaves immobilized N. The leaves of all browse species immobilized P, but the manure released P. The results suggested that some browse leaves cannot meet the N and P requirements of crops due to their low P content and prolonged N and P immobilization. However, the manures had higher P contents and rates of P mineralization, which suggested that manure is a good source of P for crops. The implications of these results for nutrient cycling in mixed farming systems is discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Melanocytic nevi typically show a morphologic sequence of maturation from epithelioid “type A” cells to fusiform, Schwann cell-like “type C” cells with dermal descent. Nevi may also produce Wagner-Meissner-like structures (nevic corpuscles). Previous studies have shown that this maturation of intradermal nevi recapitulates intermediate stages in Schwann cell development. In intradermal nevi, we have evaluated the pattern of S100A6 protein, a form of S100 found in Schwann cells.Methods: Formalin-fixed, paraffin-embedded archival tissues were evaluated by immunohistochemistry using antibodies specific for S100A6 and S100B in 38 intradermal nevi (IDN). Ten neurofibromas (NF), 3 Schwannomas (SCH), 2 palisaded and encapsulated neuromas (PEN), and 2 granular cell tumors (GCT) were included as positive controls since these lesions have large numbers of Schwann cells.Results: Melanocytic nevi demonstrated preferential anti-S100A6 staining of “type C” cells (36/38; 28 strong, 8 weak) and nevic corpuscles (25/38; 19 strong, 6 weak) compared to “type A” cells (17/38; 17 weak) and “type B” cells (17/38; 4 strong, 13 weak). All NF, SCH, and PEN stained strongly with anti-S100A6. Both GCT were negative with anti-S100A6 but positive with anti-S100B.Conclusions: The pattern of S100A6 expression in intradermal nevi further supports the hypothesis that maturation in these lesions recapitulates features of Schwann cell differentiation. The lack of S100A6 expression by both GCT suggests that these lesions have lost this feature of Schwann cells, which may play a role in their peculiar phenotypic appearance.
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  • 4
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been shown previously that there is a greater gastric mucosal blood flow response to histamine than to gastrin stimulation for similar acid secretory values. We have confirmed these observations under steady state conditions and also shown that the oxygen consumption depends on acid secretion in a similar way for both histamine and gastrin stimulation. Furthermore the degree of oxygen extraction from the gastric circulation is significantly less (p〈0.001) during histamine stimulation than during gastrin stimulation. This supports the hypothesis that histamine causes a vasodilatation in the gastric mucosa in two ways, one may be linked to secretory activity and the other a pure dilator action.
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  • 5
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Growth hormone-release inhibiting hormone (somatostatin) inhibits the gastric acid response to food in concious cats. We have confirmed that this tetradecapeptide blocks the food stimulated gastrin release. However, the inhibition of gastrin release is delayed relative to that of acid secretion, showing that the inhibition of food stimulated acid secretion is by a primary effect on the acid secretory mechanism. No evidence was found of potentiation of either the gastric acid output or serum concentration of gastric in response to food.
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  • 6
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of cyclic somatostatin on pentagastrin-and histamine-stimulated gastric acid secretion in conscious cats was studied. Evidence is produced that somatostatin competitively inhibits pentagastrin-stimulated gastric acid secretion whereas it inhibits histamine-stimulated secretion by a mechanism which is not competitive in nature. The vagus nerves seem to be involved in the mode of action of somatostatin as the inhibitory effects are greater in vagotomized than in vagus intact animals.
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  • 7
    ISSN: 1432-136X
    Keywords: Key words Harbour porpoise ; Metabolic rate ; Ventilation ; Aerobic dive limit ; Blood oxygen binding ; AbbreviationsADL aerobic dive limit ; BMR basal metabolic rate ; BTPS body temperature and pressure, saturated ; βNB non-bicarbonate buffering capacity ; CCO2 total CO2 concentration ; fH heart rate ; fR breathing frequency (breaths ; min−1) ; IHR instantaneous heart rate ; Mb body mass (kg) ; P50 the partial pressure of oxygen at which 50% of the haemoglobin is saturated with oxygen ; PO2 partial pressure of oxygen (kPa) ; PCO2 partial pressure of carbon dioxide (kPa) ; PEFR peak expiratory flow rate (l  ;  sec−1) ; PIFR peak inspiratory flow rate (l  ;  sec−1) ; RQ respiratory quotient ; Td breath-hold duration (s) ; Tex time for expiration (s) ; Tin time for inspiration (s) ; Ts surface time (s) ; Ttot total duration for one ventilation cycle (s) ; TLC total lung capacity (l) ; Ve minute volume (l  ;  min−1) ; Vt tidal volume (l) ; V˙O2 rate of oxygen consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The respiratory physiology, heart rates and metabolic rates of two captive juvenile male harbour porpoises (both 28 kg) were measured using a rapid-response respiratory gas analysis system in the laboratory. Breath-hold durations in the laboratory (12 ± 0.3 s, mean ± SEM) were shorter than field observations, although a few breath-holds of over 40 s were recorded. The mean percentage time spent submerged was 89 ± 0.4%. Relative to similarly-sized terrestrial mammals, the respiratory frequency was low (4.9 ± 0.19 breaths · min−1) but with high tidal volumes (1.1 ± 0.01 l), enabling a comparatively high minute rate of gas exchange. Oxygen consumption under these experimental conditions (247 ± 13.8 ml O2 · min−1) was 1.9-fold higher than predicted by standard scaling relations. These data together with an estimate of the total oxygen stores predicted an aerobic dive limit of 5.4 min. The peak end-tidal O2 values were related to the length of the previous breath-hold, demonstrating the increased oxygen uptake from the lung for the longer dives. Blood oxygen capacity was 23.5 ± 1.0 ml · 100 ml−1, and the oxygen affinity was high, enabling rapid oxygen loading during ventilation.
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 38 (1966), S. 1085-1086 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
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