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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  84. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20130508-20130512; Nürnberg; DOC13hnod134 /20130415/
    Publication Date: 2013-04-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20140511-20140514; Dresden; DOCMO.06.01 /20140513/
    Publication Date: 2014-05-14
    Keywords: deep brain stimulation ; essential tremor ; vim ; ddc: 610
    Language: English
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguK4-3 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010; 20100921-20100925; Mannheim; DOCV1670 /20100916/
    Publication Date: 2010-09-17
    Keywords: ddc: 610
    Language: English
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  27. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, Interventionelle und Refraktive Chirurgie (DGII); 20130411-20130413; Heidelberg; DOC13dgii057 /20130405/
    Publication Date: 2013-04-06
    Keywords: ddc: 610
    Language: German
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  • 6
    ISSN: 1432-1211
    Keywords: Key words Molecular convergence ; New World monkeys ; HLA-DRB ; Major histocompatibility complex evolution ; Gene conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract   In both Old World and New World monkeys Mhc-DRB sequences have been found which resemble human DRB1*03 and DRB3 genes in their second exon. The resemblance is shared sequence motifs and clustering of the genes or the encoded proteins in phylogenetic trees. This similarity could be due to common ancestry, convergence at the molecular level, or chance. To test which of these three explanations applies, we sequenced segments of New World monkey and macaque genes which encompass the entire second exon and large parts of both flanking introns. The test strongly supports the monophyly of New World monkey DRB intron sequences. The phylogenies of introns 1 and 2 from DRB1*03-like and DRB3-like genes are congruent, but both are incongruent with the exon 2-based phylogeny. The matching of intron 1- and intron 2-based phylogenies with each other suggests that reciprocal recombination has not played a major role in exon 2 evolution. Statistical comparisons of exon 2 from different DRB1*03 and DRB3 lineages indicate that it was neither gene conversion (descent), nor chance, but molecular convergence that has shaped their characteristic motifs. The demonstration of convergence in anthropoid Mhc-DRB genes has implications for the classification, age, and mechanism of generation of DRB allelic lineages.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 186 (1955), S. 82-83 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: Keywords HIV protease inhibitors ; lipodystrophy syndrome ; diabetes mellitus ; insulin resistance ; insulin signalling.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Patients treated with human immunodeficiency virus-1 protease inhibitors often develop impaired glucose tolerance or diabetes, most likely due to an induction of insulin resistance. We therefore investigated whether the protease inhibitor indinavir alters insulin signalling. Methods. We incubated HepG2 cells for 48 h without or with indinavir (100 μmol/l). Subsequently 125I-insulin binding to the cells and the effects of insulin stimulation on insulin-receptor substrate-1-phosphorylation, association of phosphatidylinositol 3-kinase with insulin-receptor substrate-1 and Akt-Thr308-phosphorylation were measured. Results. In cells not exposed to indinavir, insulin (100 nmol/l) led to rapid increases of insulin-receptor substrate-1-phosphorylation, association of phosphatidylinositol 3-kinase with insulin-receptor substrate-1 and Akt-phosphorylation during the first 75 s, followed by subsequent decreases. In indinavir-treated cells, these insulin-stimulated increases during the first 75 s were reduced by 30–60 % and this was not associated with alterations in cell number or viability, insulin binding to the cells or cellular insulin-receptor substrate-1-content. Conclusion/interpretation. Effects of indinavir on initial insulin signalling could cause, or contribute to, the metabolic effects of human immunodeficiency virus-1 protease inhibitors. [Diabetologia (2000) 43: 1145–1148]
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1285
    Keywords: Key words Lyme disease – borreliosis – cardiomyopathy – myocarditis – heart failure ; Schlüsselwörter Lyme-Karditis – Borreliose – Kardiomyopathie – Myokarditis – Herzinsuffizienz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine kardiale Beteiligung wird bei der Lyme-Borreliose in ca. 4–10% beobachtet. Zu den häufigsten Frühmanifestationen der akuten Lyme-Karditis zählen Reizleitungsstörungen sowie eine Perimyokarditis. Aufgrund der eingeschränkten Sensitivität und Spezifität sowie mangelnder Standardisierung der laborchemischen Testverfahren (ELISA, Westernblot, PCR) muss die Diagnose durch eine synoptische Wertung von Anamnese, Serologie und klinischen Befunden gestellt werden. Seit wenigen Jahren mehren sich Hinweise, dass ein kausaler Zusammenhang zwischen der Entstehung einer inflammatorischen dilatativen Kardiomyopathie und einer chronischen Borrelieninfektion besteht. Nach dem erfolgreichen Nachweis von Spirochäten aus dem Endomyokardgewebe bei Patienten mit dilatativer Kardiomyopathie konnte in Seroprävalenzstudien signifikant häufiger eine positive Immunserologie nachgewiesen werden (26% gegenüber 8% in der Referenzpopulation). In mehreren Therapiestudien zeigte sich eine Besserung bzw. Normalisierung der linksventrikulären Funktion unter antimikrobieller Therapie. Voraussetzung hierfür scheint allerdings ein entsprechend frühzeitiger Therapiebeginn vor Eintritt struktureller Myokardveränderungen zu sein.
    Notes: Summary Heart involvement of Lyme disease occurs in about 4–10% of patients with Lyme borreliosis. The most common manifestation is acute, self-limiting Lyme carditis, which manifests mostly as transient conduction disorders of the heart, pericarditis and myocarditis. Laboratory tests (ELISA, immunoblotting and PCR) usually have limited sensitivity and specifity, and criteria of performance and interpretation have not yet been fully evaluated. Therefore the laboratory evidence should only be interpreted in conjunction with other clinical and diagnostic features. Recently there has been convincing evidence published that long standing dilated cardiomyopathy in many cases is associated with a chronic Borrelia burgdorferi (BB) infection. Several studies showed a higher prevalence of BB antibodies in patients with severe heart failure in endemic areas (e.g., 26% versus 8% in healthy individuals). The isolation of spirochetes from the myocardium gave further evidence that BB may cause chronic heart muscle disease. In several studies antimicrobial treatment showed an improvement of the left ventricular function in patients with dilated cardiomyopathy associated with BB. However the duration of dilated cardiomyopathy before treatment plays an important part in the clinical outcome of BB-associated chronic myocarditis.
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  • 10
    ISSN: 1435-1463
    Keywords: Keywords: Membrane breakdown ; phospholipids ; phospholipase A2 ; phosphatidylcholine ; glycerophosphocholine ; choline.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in acute (stroke) and chronic (senile dementia) neurological disorders. The present review summarizes recent experimental and clinical work which concentrated on changes of choline-containing phospholipids as indicators of neuronal membrane breakdown. Experimental studies identified glutamate release, calcium influx, and activation of cellular phospholipase A2 (PLA2) as important steps initiating membrane breakdown in cultured neurons or brain slices under hypoxic or ischemic conditions. Proton NMR studies have shown an elevation of choline-containing compounds in the brain of Alzheimer patients while neurochemical studies in post mortem-brain demonstrated increases of the catabolic metabolite, glycerophosphocholine, an indicator of PLA2 activation. In contrast, studies of cerebrospinal fluid, phosphorus NMR studies, and measurements of phospholipases in post mortem Alzheimer brain gave ambiguous results which may be explained by methodical limitations. The finding that, in experimental studies, choline was a rate-limiting factor for phospholipid biosynthesis has stimulated clinical studies aimed at counteracting phospholipid breakdown, e.g. by combinations of choline and cytidine. Future experimental approaches should clarify whether loss of membrane phospholipids is cause or consequence of the neurodegenerative disease process.
    Type of Medium: Electronic Resource
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