Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2000-2004  (4)
  • 1945-1949  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 150 (2004), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Based on the increasing knowledge of T-cell-mediated pathogenesis in atopic dermatitis (AD), systemic immunosuppressive drugs are increasingly applied. The chronic, relapsing course of severe AD necessitates a drug, both efficacious and safe in long-term application. Leflunomide is a pyrimidine de novo synthesis-inhibiting immunosuppressant exhibiting an extremely long in vivo half life of its active metabolite.Objectives  To evaluate the efficacy of leflunomide in long-term treatment of AD.Methods  As a proof of principle, we treated two patients with severe AD, recalcitrant to different systemic treatment modalities, for 20 months with leflunomide (loading dose 100 mg daily during 3 days; maintenance dose 20 mg daily). At regular visits physical examination, eczema area and severity index (EASI), visual analogue scale (VAS) for itching, and laboratory findings were assessed with according adjustment of the leflunomide dose.Results  At the initiation of leflunomide therapy, both patients presented with almost erythrodermic AD (patient 1, EASI 40·0, VAS 10; patient 2, EASI 43·0, VAS 8). Partial remission was observed within 4 and 7 weeks, respectively, and maintained over 20 months (patient 1, median EASI 4·2, median VAS 2; patient 2, median EASI 8·4, median VAS 2) except for one episode of exacerbation in each case. In one patient, remission was stable even after cessation of drug dosing. Severe adverse events were not observed.Conclusions  Leflunomide was efficient in the long-term treatment of recalcitrant AD. Controlled studies will be necessary to evaluate the subset of severe AD patients benefiting most from this drug.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This investigation examined primarily epidermal specializations of the adult horse tongue by light, scanning and transmission electron microscopy. Samples were collected from seven regions of the normal tongue of various breeds of horse. The filiform papillae, present on the dorsal and lateral aspects but not the ventral aspect of the tongue, were short, slender and finger-like structures with variable-shaped terminae. The epidermal thickness and height of dermal ridges were reduced on fungiform and vallate papillae, but tissue architecture and keratinocyte ultrastructure of most of the lingual epidermis corresponded to the common mammalian epidermal paradigm. One unique finding was the highly localized clustering of epidermal cells with exceptionally high content of PAS-negative trichohyalin cytoplasmic granules at a location atop the dermal ridges and beneath the base of filiform papillae. These granular cells were immediately subjacent to clusters of clear, non-granulated epidermal cells. It is believed that this integumentary specialization may enhance the structural strength at this localized site of the tissue architecture, in relationship to the mechanical papillae.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Microscopic studies on the cetacean tongue are limited and, to date, only a few ultrastructural reports on dolphins have been published. This report presents the initial description of the lingual ultrastructure of the long-finned pilot whale. The lingual integumental surface was smooth, lacking papillae, although flaking of outer stratum corneum cells could be observed at high resolution. The keratinocytes of the stratum spinosum of the epidermis resembled those of cetacean skin on other regions of the body. The similarities included the presence of cytoplasmic lipid droplets around the nuclei of stratum spinosum cells, a lingual feature not seen in terrestrial mammals. Keratin intermediate filaments were numerous and occasionally formed aggregates of circular whorls. At cell surfaces, bundles of keratin intermediate filaments were frequently observed inserting into desmosomal plaques. Pigment granules were not evident and organelles were sparse. Stratum corneal cells contained nuclear remnants (parakeratosis) and small multivesicular bodies, and the corneal layer was approximately 18 cells thick. The nuclei of the stratum basale keratinocytes possessed exceptionally numerous and deep clefts. The dermis was non-distinctive. The skeletal muscle of the tongue was arranged in widely separated fasiculi containing small numbers of muscle fibres. Typical fine structure of skeletal muscle bands and tubular elements was observed by transmission electron microscopy.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The tongue of the Florida manatee (Trichechus manatus latirostris) was studied macroscopically, light and electron microscopically. The tongue was slender, muscular and firmly fixed in the oral cavity; only the cranial tip was free and mobile. Numerous filiform papillae were distributed over the dorsal surface of the rostral tongue. Multiple raised, round fungiform-like papillae were distributed over most of the dorsum. Typical fungiform papillae were restricted to the lateral margins of the tongue. Foliate papillae, presenting as multi-fossulate openings, were noted on the caudolateral margins. Open pits were located on the dorsocaudal surface and lateral walls. Microscopic examination showed that most of the lingual dorsum was covered with a thick stratified squamous epithelium. Open pits led to well-developed mucous salivary glands. Glands within the foliate papillae were mostly mucous, although some seromucous glands were present. Taste buds were restricted to the epithelium of the foliate papillae. Throughout the tongue, striated muscle was abundant below the epithelium. Blood vessels, lymph channels and nerve fibres were freely distributed throughout the intermuscular stroma. Nerve fibres reacted positively with neurone specific enolase (NSE) antibody throughout the tongue, including nerve bundles, glands and taste buds. Clear to translucent vacuoles were found juxtaposed to nuclei in the stratum spinosum in the foliate papillae epithelium.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 9 (1947), S. 651-672 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...