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  • 1
    ISSN: 1433-0474
    Keywords: Schlüsselwörter ; Faziale Spaltbildungen ; Kongenitale Herzfehler ; Echokardiographie ; Endokarditisprophylaxe ; Key words ; Facial clefts ; Congenital heart defects ; Echocardiography ; Endocarditis prophylaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Introduction: Children with facial clefts have an increased risk for further congenital malformations. The heart and most other organ systems may be also affected. The reported incidence of cardiac defects varies considerably. Methods and patients: In a prospective study during 6 years, 110 children, age 1 week to 4 years, were examined clinically and by colour-Doppler echocardiography. Results: The incidence of associated congenital heart defects (24,5%) was greater than in most previous reports. The incidence correlated also with the severity of the facial cleft. Syndromatic and premature children were prevalent (10% respectively 16%) and had more often cardiac defects (73% respectively 56%) than others. Most cardiac defects were ”simple”, and a half of them require prophylaxis for endocarditis. In 5 asymptomatic children cardiac defects requiring endocarditis prophylaxis were first detected by echocardiography. Conclusion: Repair of facial clefts begins usually in the first few months of life. If a cardiac defect is present, these infants have an increased perioperative risk for endocarditis. In order to detect such defects before operation, all these children should be examined by echocardiography, also when the clinical examination was uneventful.
    Notes: Zusammenfassung Hintergrund: Kinder mit fazialer Spaltbildung haben ein erhöhtes Risiko einer weiteren Fehlbildung. Das Herz und die meisten anderen Organsysteme können betroffen sein. Die Literaturangaben über die Inzidenz von Herzfehlern schwanken erheblich. Methode und Patienten: In einer prospektiven Studie über 6 Jahre wurden 110 Kinder mit Gesichtsspalten im Alter von 1 Woche bis 4 Jahren klinisch und farbdopplerechokardiographisch untersucht. Ergebnisse: Die Inzidenz assoziierter Vitien betrug 24,5% und lag damit höher als in den meisten Literaturangaben; sie korrelierte auch mit der Schwere der Spaltbildung. Kinder mit Syndromen sowie Früh- und Mangelgeborene waren häufig (10% bzw. 16%) und hatten viel häufiger Herzfehler (73% bzw. 56%) als die übrigen Kinder. Es fanden sich überwiegend einfache Vitien, von denen die Hälfte eine Endokarditisprophylaxe benötigten. Bei 5 asymptomatischen Kindern wurden erstmals durch die Echokardiographie Herzfehler festgestellt, für die eine Endokarditisprophylaxe unabdingbar war. Schlußfolgerungen: Die operative Korrektur der Gesichtsspalten wird in den ersten Lebensmonaten begonnen. Wenn ein Vitium vorliegt, haben die Kinder ein erhöhtes perioperatives Endokarditisrisiko. Um ein Vitium vor der Operation zu erkennen, sollten diese Kinder in den ersten Lebenswochen, auch bei unauffälligem klinischem Befund, echokardiographisch untersucht werden.
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 7266-7274 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have performed small- and large-angle x-ray scattering experiments on CdTe/MnTe superlattices. The Fresnel optical method and the distorted wave Born approximation were used to extract from small-angle measurements out-of-plane and in-plane information about the interfaces. Specular reflectivity shows that the interface roughness is quite high (about 7 Å) for all superlattices. The effective MnTe concentration, directly determined from the refractive index profile, is successfully used to simulate the structured nonspecular scattering, and to determine the lateral correlation length of the interface roughness (about 1500±750 Å). Moreover, it is shown that the layers are almost completely correlated over the sample thickness. The thickness fluctuations along the growth direction are estimated from the analysis of the large-angle (004) reflection, and the effective MnTe profile is also checked by dynamical simulation. It is shown that the small- and large-angle results are in good agreement. The MnTe profile width deduced from x-ray reflectivity is slightly overestimated due to the large integration area of this technique. An estimation of the local MnTe profile is given. © 2000 American Institute of Physics.
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 88 (2000), S. 4889-4897 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The x-ray standing wave method is used in correlation with reflection high-energy electron diffraction and scanning tunneling microscopy to investigate the crystallographic features of MnTe monolayers inserted in CdTe (001). Either conventional molecular beam epitaxy or atomic layer epitaxy were employed for the formation of the CdTe starting surface, the deposition of the MnTe fractional monolayer, and its encapsulation by CdTe. Significant differences concerning the ratio of Mn atoms involved in MnTe clusters to those incorporated as part of a CdMnTe alloy are observed between the samples. Those differences are due to differing CdTe starting surface roughness. © 2000 American Institute of Physics.
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  • 4
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe a newly developed ultrahigh vacuum (UHV) experiment which combines molecular beam techniques and in situ surface spectroscopy. It has been specifically designed to study the reaction kinetics and dynamics on complex model catalysts. The UHV system contains: (a) a preparation compartment providing the experimental techniques which are required to prepare and characterize single-crystal based model catalysts such as ordered oxide surfaces or oxide supported metal particles; and (b) the actual scattering chamber, where up to three molecular beams can be crossed on the sample surface. Two beams are produced by newly developed differentially pumped sources based on multichannel arrays. The latter are capable of providing high intensity and purity beams and can be modulated by means of a vacuum-motor driven and computer-controlled chopper. The third beam is generated in a continuous or pulsed supersonic expansion and is modulated via a variable duty-cycle chopper. Angular and time-resolved measurements of desorbing and scattered molecules are performed with a rotatable doubly differentially pumped quadrupole mass spectrometer with a liquid-nitrogen cooled ionizer housing. Time-resolved but angle-integrated measurements are realized with a second nondifferentially pumped quadrupole mass spectrometer. In situ measurements of adsorbed species under reaction conditions are performed by means of an adapted vacuum Fourier transform infrared spectrometer. The spectrometer provides the possibility of time-resolved measurements and can be synchronized with any of the beam sources. This contribution provides a general overview of the system and a description of all new components and their interplay. We also present test data for all components employing simple adsorption/desorption and reaction systems. © 2000 American Institute of Physics.
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  • 5
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Combining molecular beam techniques and time-resolved infrared reflection absorption spectroscopy (TR-IRAS) we have studied the kinetics of the CO oxidation reaction on an alumina-supported Pd model catalyst. The Pd particles are deposited by metal evaporation under ultrahigh vacuum (UHV) conditions onto a well-ordered alumina film, prepared on a NiAl(110) single crystal. Particle size, density and structure of the Pd deposits have been characterized in previous studies. In the low temperature region, transient and steady-state experiments have been performed over a wide range of CO and oxygen fluxes by crossing two effusive molecular beams on the sample surface. We determine the steady-state CO2 production rate as a function of the CO fraction in the impinging gas flux. Simultaneously, the occupation of CO adsorption sites under steady-state conditions is monitored by in situ IR spectroscopy. The origin of different types of CO2 transients is discussed. In particular we focus on the transient CO2 production after switching off the CO beam. For the model catalyst investigated, detailed reaction rate measurements in combination with time-resolved IRAS show that the origin of the particular transient behavior of the supported model system is not due to the presence of specific adsorption sites on small particles, as has been proposed previously. Instead, we show that the transient behavior can be semiquantitatively simulated on the basis of a simple kinetic model considering a homogeneous surface, and accounting for the inhibition of the dissociative adsorption of O2 at high CO coverage. Moreover, it is discussed how the inherent heterogeneity of the supported particle system can additionally enhance the observed effect. © 2001 American Institute of Physics.
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  • 6
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Line-mixing effects are studied in infrared bands of CH4 perturbed by N2 at various pressures. The effects of temperature are investigated in the ν3 region whereas spectral shapes of the ν2, ν4, and ν3 bands are compared at room temperature. The theoretical approach proposed in preceding papers is used in order to model and analyze the influence of collisions on the spectral shape. All model parameters are now fixed to values determined in the previous studies. Comparisons between measurements and spectra computed with and without the inclusion of line mixing are made. They show that our approach satisfactorily accounts for the effects of temperature, pressure, and of rotational quantum numbers on the absorption by the ν3 band. Furthermore, the effects of collisions on spectra in the ν4 region at room temperature are also correctly calculated. On the other hand, the proposed approach fails in modeling the evolution with increasing pressure of absorption in the spectral range containing the ν2 band. This result is attributed to the Coriolis coupling between the ν2 and ν4 vibrational states and to a contribution whose physical origin remains unclear. The latter, which is negligible when CH4–He mixtures are considered, behaves as collision-induced absorption. © 2000 American Institute of Physics.
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  • 7
    ISSN: 1569-8041
    Keywords: brain metastases ; germ-cell cancer ; high-dose chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose:To examine the feasibility and efficacy of first-linehigh-dose chemotherapy (HD-CTX) in patients with advanced metastatic germ-celltumors (GCT) and brain metastases. Patients and methods:Twenty-two patients with brain metastasesat initial diagnosis were identified within a cohort of two hundred thirty-oneconsecutive patients with advanced metastatic disease, entered on a Germanmulticenter trial between January 1993 and July 1998. All patients receivedfirst-line HD-CTX with cisplatin–etoposide–ifosfamide (HD-VIP)followed by autologous stem-cell transplantation. Brain irradiation (BRT) with30–50 Gy ± 10 Gy boost was applied in patients with symptomaticCNS disease or as consolidation in case of residual CNS lesions after HD-CTX. Results:A median number of 4 HD-CTX cycles (range 2–5) wereapplied to the 22 patients. Ten patients received HD-CTX alone and twelvepatients were treated with HD-CTX plus BRT. Median duration of WHO grade 4granulocytopenia and thrombocytopenia was seven and five days after eachcycle, respectively. Non-hematologic toxicity consisted mainly ofmucositis/enteritis (WHO grade 3–4 32%). Two early deathsoccurred in twenty-two patients (one CNS-bleeding/one sepsis). Fourteen oftwenty patients achieved a CR/PRm− status. Twenty patients (91%)responded in the brain (55% CR/36% PR). Two-yearprogression-free and overall survival rates were 72% and 81%,respectively. These survival rates are substantially higher compared to theavailable data in the literature. Conclusions:High-dose chemotherapy with autologous stem-cellsupport ± BRT appears to be feasible without increased therapy-relatedmortality in patients with advanced metastatic GCT and brain metastases. Theresults achieved emphasize the high chemosensitivity of CNS metastases fromGCT and suggest a potential role for dose intensification. The dose of BRT inaddition to HD-CTX may be tailored to the presence of clinical symptoms andthe response of CNS metastases to chemotherapy.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 22 (1934), S. 451-452 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 123-127 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The integrated intensities of the collision-induced enhancement spectra of the ν2 band of CH4 perturbed by rare gases and linear molecules (N2, H2, and CO2) are calculated theoretically using the quadrupole transition moment obtained from an analysis of CH4–Ar spectra. In addition to the isotropic quadrupole mechanism responsible for the enhancement in CH4-rare gases, there is additional absorption arising from the anisotropic quadrupole mechanism in the case of molecular perturbers. This latter effect involves the matrix element of the anisotropic polarizability for the ν2 transition in CH4 that is available from the analysis of the depolarized Raman intensity measurements. Overall, the theoretical values for the slope of the enhancement spectra with respect to the perturber density are in reasonably good agreement with the experimental results, thus confirming that the collision-induced absorption arises primarily through the quadrupolar induction mechanism. © 2002 American Institute of Physics.
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 9000-9010 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The classical path method proposed by Neilsen and Gordon [J. Chem. Phys. 58, 4131 (1973)] is tested by comparison with extensive fully quantal calculations and recent measurements of cross-sections for HF-Ar. Widths and shifts are found to be in satisfactory agreement both with the close-coupling and experimental results. Comparisons are also made with more "downgraded" theoretical approaches based on the peaking approximation and the neglect of the time ordering. Finally, the Neilsen and Gordon approach is used in order to demonstrate that vibration-rotation coupling significantly contributes to the rotational dependence of both widths and shifts cross-sections. © 2000 American Institute of Physics.
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