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  • 1
    ISSN: 1432-2307
    Keywords: Key words Clinical course ; Immunohistochemistry ; Morphology ; Primary gastric T-cell lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In contrast to primary gastric lymphomas of B-cell type, little is known about primary gastric T-cell lymphomas. We describe three cases with remarkably similar features: diffuse growth, epitheliotropism, medium too large cell size, high apoptotic rates, and a CD3+, CD4+, CD8+, CD45RO+ immunophenotype. Clonal TCRγ gene rearrangement was shown in two cases. Epstein-Barr virus infection was excluded in two cases. Taking advantage of fresh-frozen material, we analyzed two cases further, revealing CD5–, CD16+, CD56–, CD57–, CD25+, CD30+, CD103 (αEβ7)+, bcl-2 protein+, CD95+, CD95 ligand(L)–. CD95L, however, was detected in histiocytic and fibroblastoid by stander cells. The lymphomas expressed granzyme B, perforin, and the TIA-1 antigen in various combinations. All three cases had a very unfavorable clinical course characterized by local recurrence and/or dissemination to other epithelial sites, leading to death within 6–12 months after the initial diagnosis despite surgery and aggressive antineoplastic treatment. These data suggest a novel variant of peripheral T-cell lymphoma operationally characterized as primary gastric, apoptosis-rich, CD103+, EBV-, T-cell lymphoma co-expressing CD4, CD8, CD16 and cytotoxic molecules.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1569-8041
    Keywords: 11q22–q23 deletion ; ataxia-telangiectasia ; ATM ; mantle-cell lymphoma ; tumor suppressor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Mantle-cell lymphoma (MCL) is geneticallycharacterized by the translocation t(11;14)(q13;q32) leading to anoverexpression of cyclin-D1, but additional chromosomal abnormalities appearto be required for MCL pathogenesis. Patients and methods:Deletions involving chromosome 11q, whichwere recently found as recurrent aberrations in MCL, were analyzed at themolecular level in a series of 81 MCL by fluorescence in situhybridization (FISH) with probes from a contiguous set of yeastartificial chromosomes (YACs) spanning bands 11q14–q24. Results and conclusions:Loss of chromosome 11 material wasobserved in 37 of the 81 MCL cases (46%). The consensus deletioncomprised YAC 801e11 containing the ATMgene. The minimal region ofloss was further narrowed with P1–derived artificial chromosome (PAC) probes.This allowed the identification of a deletion confined to the genomic regionof ATM, which, together with intragenic mutations found in the codingsequence, suggests a role of ATMas a tumor suppressor gene in MCL.
    Type of Medium: Electronic Resource
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