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  • 2000-2004  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has become clear that the immune and nervous systems communicate constantly to maintain homeostasis and a coordinated and continuing adaptive response to an ever-changing environment. Evidence from mast cell nerve communication, as an example of this interaction, has been obtained in a variety of tissues and circumstances, most especially in the intestine and skin. Bidirectional communication has been shown in vivo, ex vivo, in vitro and in coculture experiments involving the two cell types. Examples will be given of these various situations and involve normal physiological situations and those involved in response to infection and inflammation as well as in response to ultraviolet light. More recent examples of the importance of mast cells in the regulation of central nervous activity including the secretion of hormones by the pituitary gland, and thereby the regulation of the HPA axis as well as involvement in behavioural change will be addressed. Through its potential communication with the nervous system, the mast cell can be regarded as a sentinel cell or receptor, especially located at surfaces exposed to the environment, which specifically and non-specifically react to molecules and substances, foreign to the organism, so as to help orchestrate the complex and integrated responses required to maintain homeostasis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitively suggests that these enigmatic, multifacetted protagonists of natural immunity are functionally relevant to many more aspects of tissue physiology than just to the generation of inflammatory and vasodilatory responses to IgE-dependent environmental antigens. And yet, for decades, mainstream-mast cell research has been dominated by a focus on the – undisputedly prominent and important – mast cell functions in type I immune responses and in the pathogenesis and management of allergic diseases. Certainly, it is hard to believe that the very large and rather selectively distributed number of mast cells in normal, uninflamed, non-infected, non-traumatized mammalian skin or mucosal tissue is simply hanging around there lazily day and night, just to wait for the odd allergen or parasite-associated antigen to come by so the mast cell can finally swing into action. Indeed, the past decade has witnessed a renaissance of mast cell research ‘beyond allergy’, along with a more systematic exploration of the surprisingly wide range of physiological functions that mast cells may be involved in. The current debate sketches many of the exciting new horizons that have recently come into our vision during this intriguing, ongoing search.
    Type of Medium: Electronic Resource
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