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  • 1
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We examine the soft supersymmetry breaking parameters in supersymmetric theories on a slice of AdS5 which generate the hierarchical Yukawa couplings by dynamically quasi-localizing the bulk matter fields in an extra dimension. Such models can be regarded as the AdS dual of the recently studied 4-dimensional models which contain a supersymmetric CFT to generate the hierarchical Yukawa couplings. In such models, if supersymmetry breaking is mediated by the bulk radion superfield and/or some brane chiral superfields, potentially dangerous flavor-violating soft parameters are suppressed with an appropriate correlation with the Yukawa coupling suppression, thereby avoiding the SUSY flavor problem in a natural manner. We present some models of radion-dominated supersymmetry breaking which yield a highly predictive form of soft parameters in this framework, and discuss the constraints from flavor-changing rare processes. Most of the discussions in this paper can be applied also to models with a flat extra dimension in which the Yukawa hierarchy is generated by quasi-localizing the bulk matter fields in the extra dimension.
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  • 3
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Elution chromatographic separation of lithium isotopes was carried out with aminobenzo-15-crown-5 bonded merrifield resin. This resin have a capacity of 0.24 meq/g dry resin. By column chromatography using 1.0M NH4Cl solution as an eluent, a single separation factor 1.026 was obtained from the elution curve and isotope ratios according to the Glucckauf theory. The heavier isotope, 7Li was concentrated in the resin phase, while the lighter isotope, 6Li enriched in the solution phase.
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  • 4
    ISSN: 1439-0264
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of serotonin immunoreactivity in the main olfactory bulb (MOB) of the Mongolian gerbil (Meriones unguiculatus) was examined by immunohistochemistry. Seven distinct layers of the Mongolian gerbil MOB-stained with cresyl violet were identified. Serotonin-immunoreactive (IR) cell bodies were not found in the MOB. The serotonin-IR nerve fibres had a specific laminar distribution and morphology in the gerbil MOB. Serotonin-IR nerve fibres were observed in the glomerular, external plexiform and granule cell layers of the MOB. These serotonin-IR nerve fibres showed varicosities that were larger than the thickness of the axon. The highest density of serotonin-IR nerve fibres was in glomeruli of the glomerular layer. The average fibre density in the glomerular layer was more than three to four times the density in the infraglomerular layers. Glomerular serotonin-IR fibres were much more intensively stained than infraglomerular serotonin-IR fibres. This result suggests that serotonin-IR nerve fibres of Mongolian gerbil MOB are extrinsic and may act to modulate the olfactory transmission.
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 551-564 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: InGaAs/AlGaAs quantum well structures have been shown to be versatile for infrared detection. By changing the material composition, one can tune the detection wavelength from 2 to 35 μm and beyond. However, there have been few systematic calculations on the absorption wavelength of these structures with respect to their structural parameters. In this work we have adopted the transfer-matrix method to calculate both their energy levels and the wave functions. From this calculation, the absorption and the responsivity spectra of the structures can be predicted. The theory agrees with the experimental result of the test structures. Supported by the experimental evidence, we applied the calculation to a general class of midwavelength detectors and thus established a useful guideline for the detector design in this wavelength range. © 2002 American Institute of Physics.
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 88 (2000), S. 1612-1623 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this article, we discuss the utilities of corrugated quantum well infrared photodetectors (C-QWIPs) in detector material characterization. By measuring the detector responsivity as a function of corrugation period, several important detector parameters, such as the absorption coefficient α of parallel propagating light and the energy resolved photoconductive gain g, can be directly deduced. For the QWIP material presented, α at the peak was found to be 0.21 μm−1 under the usual operating condition. This value of α corresponds to an absorption length of 4.8 μm. Instead of being a constant, the value of g also varies significantly across the excitation spectrum, and the peak value is larger than the noise gain at large bias. Our results show that the present characterization technique is capable of providing accurate and detailed information on the intrinsic properties of QWIP materials under actual operating conditions. It is extremely useful in detector optimization. In addition, we also show the characteristics of C-QWIPs with an additional vertical trench at the center of each corrugation to gain more insights into the distribution of light intensity in a C-QWIP structure. © 2000 American Institute of Physics.
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  • 7
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Proton pump inhibitor-based triple therapies are recommended as the first-line treatment for Helicobacter pylori eradication.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To evaluate the efficacies of low-dose clarithromycin triple therapy and tinidazole-containing triple therapy in a metronidazole resistance prevalent area and to compare the efficacies with standard triple therapy.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:In a randomized, multicentre, prospective study, a total of 352 patients with duodenal ulcer or non-ulcer dyspepsia were randomly divided into three groups according to the administered regimen: OAC250 group (omeprazole, 20 mg, amoxicillin, 1000 mg, and clarithromycin, 250 mg), OAC500 group (omeprazole, 20 mg, amoxicillin, 1000 mg, and clarithromycin, 500 mg) and OTC group (omeprazole, 20 mg, tinidazole, 500 mg, and clarithromycin, 500 mg). The three groups received each regimen twice daily for 7 days. Upper gastrointestinal endoscopy was performed before and 4 weeks after treatment. H. pylori status was determined by rapid urease test and 13C urea breath test.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The eradication rates in the OAC250, OAC500 and OTC groups were 76.2%, 65.7% and 64.8% (95% confidence interval: 67.9–84.4%, 56.7–74.8% and 55.7–73.9%), respectively, by intention-to-treat analysis (P=0.149) and 92.8%, 87.2% and 84.1% (95% confidence interval: 84.4–97.3%, 77.9–93.8% and 73.9–91.2%), respectively, by per protocol analysis (P=0.088). All regimens were well tolerated and compliance was excellent.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Both low-dose clarithromycin triple therapy and tinidazole-containing triple therapy are effective and safe regimens for H. pylori eradication.
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  • 8
    ISSN: 1432-203X
    Keywords: Key words Pilot-scale culture ; Taxane ; Taxol ; Fed-batch culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A novel type of bioreactor was successfully developed for the production of taxol and its precursors by culturing cells of Taxus cuspidata (Japanese yew) on a pilot-scale. Rapidly growing cell lines were selected from callus cultures derived from immature embryos of yew. The cells were inoculated in 20-l capacity bioreactors of different types to test the growth performance. The models of small-scale bioreactors incorporated in this study included a balloon-type bubble bioreactor (BTBB), a bubble-column bioreactor (BCB), a BCB with a split-plate internal loop, a BCB with a concentric draught-tube internal loop, a BCB with a fluidized bed bioreactor, and two different models of stirred tank reactors. Among the reactors, BTBB appeared to be the most efficient in promoting cell growth. The doubling time of cell growth in BTBB was 12 days with a 30% inoculation cell density. The optimum time for medium replacement or feeding was 12–15 days after inoculation as determined by monitoring both the levels of sugars and medium conductivity. When yew tree cells were grown in different sizes (100–500-l) of BTBBs, more than 70% cell viability was recorded at the time of harvest. The growth pattern of the cells in the pilot-scale BTBB appeared to be the same as that of cells in the 20-l bioreactors. Approximately 3 mg/l of taxol and 74 mg/l total taxanes were obtained after 27 days of culture.
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  • 9
    ISSN: 1432-2072
    Keywords: Keywords AMPA/kainate ; Dopamine ; CNQX ; NBQX ; 7-OH-DPAT ; SKF-38393 ; Quinpirole ; Nucleus accumbens ; Core/shell ; Locomotor activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present experiments were conducted to investigate effects of α-amino-3-hydroxy-5-methyl-4-isoxazoleprionic acid (AMPA)/kainate receptor blockade (CNQX, NBQX) on locomotor responses to D2/3 (7-OH-DPAT) and D1 [(+)-SKF 38393] dopamine receptor agonists in the nucleus accumbens (NAS) core and shell. CNQX (0.25–0.5 µg) microinjected into the NAS core or shell did not affect baseline locomotor activity. 7-OH-DPAT (2.5–5 µg) decreased locomotor activity. Co- administration of CNQX (0.5 µg) increased the effects of 7-OH-DPAT (5 µg) in the NAS core and shell. A similar increase was observed with NBQX (0.5 µg) in the NAS shell. (+)-SKF 38393 (5 µg) into the NAS core and shell increased locomotor activity after 30 min; this effect was not altered by CNQX (0.5 µg). As the D2/3 dopamine agonist (–)-quinpirole (2 µg) increased effects of (+)-SKF 38393 (5 µg) in NAS shell but not core, lack of site-selective effects of (+)-SKF-38393 and of 7-OH-DPAT within NAS is not attributable to drug diffusion. The previous observation that glutamate effects on locomotor activity depend on the relative involvement of D1 or D2/3 dopamine receptors in the NAS was based on the dopamine-depletion model. The present results demonstrate differential interactions of AMPA receptor blockade with dopamine agonists in ”dopamine-intact” animals.
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  • 10
    ISSN: 1432-1750
    Keywords: Key words: Polymorphism—Endothelial nitric oxide synthase—Angiotensin-converting enzyme—Lung cancer.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The objectives of this study were to examine the possible involvement of endothelial nitric oxide synthase (ecNOS) and angiotensin-converting enzyme (ACE) genes in the genetic basis of lung cancer. Two hundred eighteen patients with lung cancer and 121 healthy subjects were included in this study. The ecNOS and ACE genotypes were determined in all subjects by polymerase chain reaction. The distribution of genotypes of ecNOS gene was significantly different in the lung cancer group than in the control population. ACE genotype distribution was not significantly different in the lung cancer group compared with the control group. These results suggest that polymorphisms of the ecNOS gene, but not the ACE gene, may be associated with the development of lung cancer.
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