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  • 1
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    Weinheim : Wiley-VCH
    Call number: D010:74
    Keywords: Vaccines
    Pages: xlii, 628 p. : ill. (some col.)
    ISBN: 3527305238
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    D010:74 departmental collection or stack – please contact the library
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  Hypertonie 2003; 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga; 20031126-20031129; Bonn; DOC03hochP50 /20041111/
    Publication Date: 2004-11-12
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    ISSN: 1292-895X
    Keywords: PACS. 87.18.-h Multicellular phenomena – 87.18.Ed Aggregation and other collective behavior of motile cells – 64.70.-p Specific phase transitions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: In cell culture, liquid crystal analogues are formed by elongated, migrating, and interacting amoeboid cells. An apolar nematic liquid crystal analogue is formed by different cell types like human melanocytes (=pigment cells of the skin), human fibroblasts (=connective tissue cells), human osteoblasts (=bone cells), human adipocytes (=fat cells), etc. The nematic analogue is quite well described by i) a stochastic machine equation responsible for cell orientation and ii) a self-organized extracellular guiding signal, E2, which is proportional to the orientational order parameter as well as to the cell density. The investigations were mainly made with melanocytes. The transition to an isotropic state analogue can be accomplished either by changing the strength of interaction (e.g. variation of the cell density) or by influencing the cellular machinery by an externally applied signal: i) An isotropic gaseous state analogue is observed at low cell density ( melanocytes/mm^2) and a nematic liquid crystal state analogue at higher cell density. ii) The nematic state analogue disappears if the bipolar shaped melanocytes are forced to become a star-like shape (induced by colchicine or staurosporine). The analogy between nematic liquid crystal state analogue formed by elongated, migrating and interacting cells and the nematic liquid crystal phase formed by interacting elongated molecules is discussed.
    Type of Medium: Electronic Resource
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