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  • 1
    ISSN: 1432-2307
    Keywords: Key words Paired-related homeobox ; Heart development ; Pharyngeal arch arteries ; Vascular matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Prx1 (MHox) and Prx2 (S8) are non-clustered homeobox genes that are expressed in a complex, mostly mesenchyme-specific pattern throughout embryogenesis. The expression pattern and gene-targeted mice previously revealed a major role for Prx1 in skeletogenesis. In addition, specific and high expression of both Prx genes was reported in the developing cardiovascular system, predominantly in prospective connective tissues of the heart and in the great arteries and veins. We examined embryos of previously generated gene-targeted mice. Prx2-/- mutants were viable and did not show cardiovascular malformations. Intracardiac morphology of Prxl-/- and Prx1/Prx2-combined null mutants also appeared normal throughout development. However, the Prx1-/- and Prx1/Prx2 double-null mutants showed a vascular abnormality with an abnormal positioning and awkward curvature of the aortic arch in addition to a misdirected and elongated ductus arteriosus, and in two of seven combined mutants, an anomalous retro-oesophageal right subclavian artery. Generally, all great arteries appeared to run somewhat tortuously through the surrounding mesenchyme. The vascular histology and vessel wall thickness were normal in all mutants. Prx1-/- and Prx double-gene-targeted mice revealed similar spectra of vascular anomalies, but double mutants appeared to be more seriously affected. The current findings suggest that other genes may compensate for the lossof Prx in the heart, but, in contrast, our data support a role for Prx in the development of vascular and perivascular matrix.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of oral rehabilitation 30 (2003), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  The purpose of this in vitro study was to evaluate crown retention after using different sealing systems on prepared dentine. Ca(OH)2 suspension was used in comparison with three adhesive bonding systems (Gluma Desensitizer, Optibond FL, Prompt L-Pop). Extracted human premolars were uniformly prepared with the use of a special parallelometer (11° taper, 4 mm axial length). Groups of 20 teeth each were treated with each sealing system. Then crowns were fabricated and temporarily cemented twice. Finally the abutments were cleaned and the crowns were cemented with a glass–ionomer cement Ketac-Cem. Subgroups of 10 crowns were removed with a universal testing machine following storage in distilled water either for 3 days or for 150 days. Prior to dislodging, the crowns of both groups were subjected to chewing simulation. The mean dislodgement stresses in MPa were between 4ḃ9 and 6ḃ9. A range test of Student–Newmann–Keuls revealed significant differences between Ca(OH)2 and Optibond FL (P 〈 0ḃ05), while the storage time had no significant effect. The level of microleakage increased significantly with storage time (P 〈 0ḃ05). It is concluded, that the use of Gluma Desensitizer and Prompt L-Pop did not affect crown retention as compared with Ca(OH)2, thus may be used in combination with glass–ionomer cement to desensitize prepared teeth.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Journal of oral rehabilitation 28 (2001), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this retrospective study was to evaluate the changes in the periodontal conditions of patients wearing different designs of removable partial dentures over long-term. Seventy-four patients treated with 101 mainly conical crown-retained dentures (CCRDs) or clasp-retained removable partial dentures (RPDs) or a combination of conical crown and clasp-retained dentures (CRPDs) were re-examined 10 years after insertion. Periodontal findings were compared with baseline values at insertion. A deterioration of the probing depths (PDs) and tooth mobility was found. The abutment teeth of the RPDs suffered more severe deterioration than the abutment teeth of the CCRDs and the CRPDs. The absence of a regular recall system for the patients may be responsible for this outcome.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  The purpose of this study was to evaluate effect of a calcium hydroxide suspension [Ca(OH)2] or glutaraldehyde based dentine primer (GDP) to reduce tooth sensitivity after full crown preparation. Thirty-six patients were treated with Ca(OH)2 on one tooth and with GDP on another. Patients completed a questionnaire regarding sensitivity during crown preparation, when the not-anaesthetized abutments were irritated [cotton pellet (20 °C)]. The teeth were tested before (T0) and after using the desensitizer (T1), again after 7 days (T2), 6 months (T3) and 30 months (T4). The results were registered on a visual analogue scale [0 (no pain)–100 (severe pain)]. The changes of tooth sensitivity between different testing times were analysed. The median and the (interquartile range) for the different time intervals for Ca(OH)2 were ΔT0–T1: 5 (6–17), ΔT0–T2: 17 (14–32), and for GDP, ΔT0–T1: 9 (7–18) ΔT0–T2: 18 (16–33), the decreases in sensitivity were lower for ΔT0–T1 than for ΔT0–T2 for both desensitizers (P 〈 0·001). There was no statistical difference (P 〉 0·05) between the agents (ΔT0–T1, ΔT0–T2, ΔT3–T4). Both substances might be useful in reducing tooth sensitivity after crown preparation, but no differences in the efficacy were found when comparing the materials.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1436-3771
    Keywords: Key words Clasp-retained dentures ; Conical crown-retained dentures ; Removable partial dentures ; Long-term results ; Clinical study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this retrospective study was to examine the condition and success rate of various designs of removable partial dentures 10 years after placement. Seventy-four patients treated with 101 mainly conical crown-retained dentures (CCRDs), clasp-retained removable partial dentures (RPDs), or a combination of conical crown and clasp-retained dentures (CRPDs) were reexamined. Prosthetic findings were compared to baseline values at insertion and checked for factors that may affect them. Overall, 36.6% of the prostheses were regarded as successes, 23.8% as partial successes, and 39.6% as failures. Also, only one-third of the prostheses showed neither hygienic problems nor technical failures. The statistical analysis identified no single parameter as significantly affecting the success rate of the partial dentures. Prostheses supported by several abutment teeth had improved success, and RPDs had a higher failure rate (66.7%) than CCRDs (33.3%) and CRPDs (44.8%); however, because of the limited number of RPDs these differences were not statistically significant. Although the prostheses were unsupervised in service, the 60.4% overall success rate of the dentures was somewhat higher than in other studies on precision-retained prostheses.
    Type of Medium: Electronic Resource
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