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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  International Conference on SARS - one year after the (first) outbreak; 20040508-20040511; Lübeck; DOC04sars10.02 /20040526/
    Publication Date: 2004-05-26
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  International Conference on SARS - one year after the (first) outbreak; 20040508-20040511; Lübeck; DOC04sarsP11.04 /20040526/
    Publication Date: 2004-05-26
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied microbiology and biotechnology 54 (2000), S. 141-152 
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Mushroom cultivation presents an economically important biotechnological industry that has markedly expanded all over the world in the past few decades. Mushrooms serve as delicacies for human consumption and as nutriceuticals, as “food that also cures”. Mushrooms, the fruiting bodies of basidiomycetous fungi, contain substances of various kinds that are highly valued as medicines, flavourings and perfumes. Nevertheless, the biological potential of mushrooms is probably far from exploited. A major problem up to now is that only a few species can be induced to fruit in culture. Our current knowledge on the biological processes of fruiting body initiation and development is limited and arises mostly from studies of selected model organisms that are accessible to molecular genetics. A better understanding of the developmental processes underlying fruiting in these model organisms is expected to help mushroom cultivation of other basidiomycetes in the future.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 71 (2000), S. 567-572 
    ISSN: 1432-0649
    Keywords: PACS: 32.30.Jc; 32.70.Jz; 32.10.Fn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. The caesium 6S 1/2? 8P 1/2,3/2 transitions at 387.6 nm and 388.8 nm have been observed with a linewidth of 〈5 MHz by laser spectroscopy. The absolute frequency of the 6S 1/2?8P 1/2 transition was determined to an uncertainty of ±1 MHz using the calibrated rubidium 5S 1/2?5D 5/2 two-photon transition and accurate interferometry. The potential of this caesium transition as a useful secondary frequency standard in blue–UV region is discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0630
    Keywords: PACS: 61.72.Y; 61.72Ff; 61.72Qq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. Structural imperfections in synthetic diamond single crystal prepared under high temperature and high pressure (HPHT) in the presence of a Fe65Ni35 catalyst have been examined with transmission electron microscopy (TEM) and moiré patterns. The existence of stacking faults, concentric dislocation loops and an array of dislocations in the diamond was suggested. The formation mechanism of these structural imperfections was analyzed briefly. It was found that the structural imperfections originate from an excess amount of saturated vacancies and internal stresses associated with inclusions in the diamond.
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  • 6
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Tyrosinase-related proteins (TRPs) include tyrosinase, TRP-1 and TRP-2. The functions of tyrosinase and TRP-2 have been determined, but the biological role of TRP-1 is still controversial and is not well known in humans.Objectives  To study further the biological role of the human TRP-1 gene in melanocytes and melanoma cells.Methods  TRP-1 cDNA was subcloned into eukaryotic expression vector pcDNA3.1 in the reverse direction, and antisense recombinant vector was transfected into melanocytes and a melanoma cell line using Lipofectamine 2000. Positive cells were selected by geneticin. TRP-1 mRNA level was measured by reverse transcription–polymerase chain reaction (RT–PCR), and TRP-1 protein level by Western blot. Cell cycles were determined by flow cytometry, and the activity of tyrosinase was evaluated by L-DOPA reaction. Light microscopy, electron microscopy and flow cytometry were used to observe cell morphology and apoptosis. For in vivo assays, the antitumour activity of antisense TRP-1 against the malignant melanoma (MM) cell line, Libr, was evaluated in an animal-tumour model of subcutaneous tumours.Results  Positive transfected cells steadily expressed TRP-1 antisense RNA. RT–PCR and Western blot showed a low level of TRP-1 mRNA and TRP-1 protein, respectively. Cell cycles were blocked in the G1 stage, and the activity of tyrosinase decreased significantly (P 〈 0·01). Light and electron microscopy showed abnormal cell morphology, and apoptosis was detected. The neoplasia activity of antisense TRP-1-transfected MM cells was significantly lower than that of MM cells (P 〈 0·01).Conclusions  TRP-1 plays an important role in the proliferation, morphology and tyrosinase activity of melanocytes and melanoma cells.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary In the past 20 years, more than 20 cases of a type of granulomatous disease have been noticed by dermatologists in different areas of China. The patients had these features in common: (i) the lesions followed a slight trauma to the face; (ii) they were spreading dark-red plaques without pus or ulceration; (iii) new lesions appeared near to or far from the original lesion; (iv) histopathology showed histiocytic granuloma; (v) the patients had severe headache and clouding of consciousness during the later stages of the disease; (vi) all patients died within 1·5–4 years; (vii) treatment with prednisone led to some healing of the lesions but accelerated death; and (viii) all patients were from rural areas. We examined the tissues from two similar patients by electron microscopy and identified two kinds of bacteria as a possible cause of the disease. One was an anaerobic actinomycete, the other was Staphylococcus capitis. The anaerobic actinomycete was sensitive to lincomycin (a forerunner of clindamycin). After a 5-month therapy with lincomycin, one patient survived. We infer that the cause of death is the unknown anaerobic actinomycete. Because the disease is very severe, we suggest the name ‘fatal bacteria granuloma after trauma’ to draw attention.
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a 33-year-old woman with a 2-year history of rheumatoid arthritis-like joint changes and a 1-year history of papulonodules on the fingers, ears, oral mucosa, forearm, elbows and thighs, and erythematous plaques on the buttocks. Six months after the onset of the cutaneous lesions she had dyspnoea, 3 months later she developed a husky sound. Biopsies from the nodules on the ear and left forearm revealed multinucleated giant cells with eosinophilic ‘ground-glass’ cytoplasm. Bronchoscopy revealed that there were nodules in the bronchus. A biopsy taken from a nodule from the bronchus was consistent with multicentric reticulohistiocytosis. Fibrostic laryngoscopy showed a mass 1.5 × 2.0 cm2 in size on the left aryepiglottic fold and posterior commissure. Magnetic resonance imaging revealed a large pleural effusion and pericardiac effusion. Ultrasound revealed splenomegaly and peritoneal fluid. Combination therapy with prednisone, cyclophosphamide and methotrexate significantly improved cutaneous and joint symptoms. The huge cutaneous erythematous plaques and the generalized systemic involvement make this case interesting.
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  • 10
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Photodynamic therapy (PDT) with aminolaevulinic acid (ALA) is used in many countries for the treatment of actinic keratoses.Objectives  The objectives of the current study were to evaluate the influence of irradiance and light dose on the localization and extent of photodamage to mouse skin following ALA-PDT.Methods  In this study we evaluated the influence of irradiance and light dose on epidermal photodamage following ALA-PDT. Groups of hairless mice received an intraperitoneal injection of ALA followed 2 h later by exposure to 12 J cm−2, 24 J cm−2 or 48 J cm−2 of unfiltered light from a slide projector. For each of these fluences, groups of mice were exposed at the following irradiances: 5 mW cm−2, 20 mW cm−2 or 40 mW cm−2. Skin biopsies were performed 24 h and 72 h later.Results  Histological localization of photodamage was influenced by irradiance and light dose. At high irradiance and low fluence, PDT photodamaged cells were mostly located in the upper area of the epidermis whereas at lower irradiance and high fluence the complete epidermis was necrotic and often absent 24 h after light exposure. Protoporphyrin IX (PpIX) fluorescence intensity was similar in the upper and lower region of the epidermis 2 h after ALA injection. The decrease in PpIX fluorescence intensity immediately after light exposure was also similar in both regions of the epidermis.Conclusions  The localization of photodamage following ALA-PDT is influenced by irradiance and light dose. This phenomenon cannot be explained by differences in PpIX intensity in the epidermis either before or after light exposure.
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